BiographyI went to Highgate School in London and graduated from University College London with a B.Sc. (first class honours) and MB.BS (with honours in medicine). After house-staff training I went to the National Institutes of Health, Bethesda Maryland, USA to study with Robert Scow and Martin Rodbell who later won the Nobel Prize for Medicine.
On returning to the UK I obtained a Fellowship at the Hammersmith Hospital to work with Russell Fraser and later elected to the consultant staff at St Bartholomew's Hospital London. I was then elected to a Professorship, Department of Medicine, London University and am now an Emeritus Professor at London University.
Areas of Research / Professional Expertise
My laboratory’s main contributions have been to reveal defects of metabolic regulatory elements in common metabolic disease (mainly diabetes mellitus, the lipemias and atherosclerosis) at both phenotype and genotype levels:
My group identified the earliest loss of an allosteric regulation of a rate-determining enzyme, phosphofructokinase by citrate in minimal deviation tumours, lipomata. Many more such defects have subsequently come to light particularly to deregulate pathways in early neoplasia.
His laboratory was the one of the first to use single nucleotide polymorphisms (SNPs) to reveal susceptibility genes that predispose individuals to develop metabolic disorders, such as hypertriglyceridemia and atherosclerosis. This led eventually to the development of Genome Wide Association Studies (GWAS) where more than 1400 susceptibility loci have now been identified using SNPs and some have led to useful therapeutic agents such as volanesorsen
My two major interests are sailing and playing the piano. My photo is of cruising the river Orwell in Sussex which leads out to the North Sea for cruises to Belgium or Holland where we go for family holidays.
I also give regular piano recitals at Morley College my repertoire including Bach, Mozart, Chopin and Schumann. At present I am preparing a Mozart sonata K 282 (his fourth) which he composed when 18 years old in Munich for a concert this June