Malte  Renz Author of Evaluating Organization Development
FEATURED AUTHOR

Malte Renz

Gynecologic Oncology Fellow
Stanford University School of Medicine

Gynecologic Oncology Fellow

Biography

Malte Renz was born in Düsseldorf, Germany, and grew up in Bremen. Malte went to Academy of Fine Arts Düsseldorf and Heinrich-Heine University to study both Fine Arts/ Painting (1997-2003) and Medicine (1998-2005). As doctoral candidate (2005-2008) and post-doctoral fellow (2008-2012), he worked in the basic research labs of the German Cancer Research Center, Heidelberg, and the National Institutes of Health, Bethesda, MD. During this time, Malte developed tools of quantitative fluorescence life cell microscopy and single molecule imaging and used these tools to address principle molecular mechanisms of disease. After his residency at the Albert Einstein College in the Bronx, NY (2012-2017), Malte is currently completing his fellowship in Gynecologic Oncology at Stanford University (2017-2020). It has been Malte’s goal to bridge basic research and patient care.

Websites

Books

Featured Title
 Featured Title - Synopsis of Key Gynecologic Oncology Trials - 1st Edition book cover

Articles

Ultrasound Obstet Gynecol

Long-term outcome of postmenopausal women with non-atypical endometrial hyperplasia on endometrial sampling.


Published: Aug 07, 2019 by Ultrasound Obstet Gynecol
Authors: Rotenberg O, Fridman D, Doulaveris G, Renz M, Kaplan J, Gebb J, Xie X, Goldberg GL, Dar P.

CONCLUSIONS: Postmenopausal women with NEH are at significant risk for persistent endometrial hyperplasia (EH) and progression to uterine cancer, at higher rates than rates previously reported. Guidelines for the appropriate management of postmenopausal women with NEH are needed to decrease the rate of persistent disease or progression to cancer.

J Minim Invasive Gynecol

Sentinel Lymph Node Biopsies in Endometrial Cancer: Practice Patterns among Gynecologic Oncologists in the United States.


Published: Apr 10, 2019 by J Minim Invasive Gynecol
Authors: Renz M, Diver E, English D, Kidd E, Dorigo O, Karam A.

CONCLUSION: In summary, despite the growing use of sentinel lymph node injection and biopsy in endometrial cancer, practice patterns vary considerably among providers sampled by this survey. Some of the decisions are based on limited evidence and, in some instances, deviate from current published guidelines

J Robot Surg

Immediate intraoperative sentinel lymph node analysis by frozen section is predictive of lymph node metastasis in endometrial cancer.


Published: Jan 28, 2019 by J Robot Surg
Authors: Renz M, Marjon N, Devereaux K, Raghavan S, Folkins AK, Karam A.

Our approach permits immediate intraoperative results and helps guide the primary surgery. The immediate SLN work-up using frozen sections showed both high accuracy and negative predictive value. The comparably lower sensitivity may be related to the low number of patients with positive lymph nodes (7.6%).

J Vis Exp

How to Quantify the Fraction of Photoactivated Fluorescent Proteins in Bulk and in Live Cells.


Published: Jan 07, 2019 by J Vis Exp
Authors: Chen V, Renz M.

Short high-power photoactivation with a confocal laser scanning microscope (CLSM) resulted in up to four times lower photoactivation efficiency than hundreds of low-level exposures applied by CLSM or a short pulse applied by widefield illumination. While the protocol has been exemplified here for (PA-)GFP and (PA-)Cherry, it can in principle be applied to any spectrally distinct photoactivatable or photoconvertible fluorescent protein pair and any experimental set-up.

bioRxiv

Cytoplasmic self-organization established by internal lipid membranes in the interplay with either actin or microtubules


Published: Dec 26, 2018 by bioRxiv
Authors: Sindy K. Y. Tang, Malte Renz, Tom Shemesh, Meghan Driscoll, Jennifer Lippincott-Schwartz
Subjects: Biomedical Science

Here, we show that lipid membranes are capable of organizing both major cytoskeletal systems, microtubules and actin, even if one or the other cytoskeletal system is completely paralyzed. A microfluidic droplet system and Xenopus oocyte extracts enabled us to build an artificial cell and study minimal requirements for cellular self-organization.

Cytometry A

Internal rulers to assess fluorescent protein photoactivation efficiency.


Published: Apr 28, 2018 by Cytometry A
Authors: Renz M, Wunder C

The tools we provide can be applied to any genetically encoded photoactivatable protein. Determination of photoactivation efficiency is essential for an understanding of absolute molecule numbers in ensemble studies and, most importantly, quantitative superresolution imaging.

PeerJ

Robotic Olympics: A novel robotic surgical training experience for residents in an obstetrics and gynecology residency program


Published: Jan 07, 2018 by PeerJ
Authors: Malte Renz, Eric Liberman, Brian Daniels, Sara Isani, Dennis Y Kuo, Nicole Nevadunsky​
Subjects: Biomedical Science

The majority of residents welcomed the addition of the Robotic Olympics to the robotic-surgical curriculum. However, the residents’ interest in robotic surgical training in general was disparate and correlated with the anticipated use of the robot in the residents’ future career. This data suggests the need for directed robotic surgical training for residents interested in surgical sub-specialties to focus resources early on.

Obstet. Gynecol.

Simultaneous Endometrial Aspiration and Sonohysterography for the Evaluation of Endometrial Pathology in Women Aged 50 Years and Older


Published: Feb 01, 2015 by Obstet. Gynecol.
Authors: Rotenberg O, Renz M, Reimers L, Doulaveris G, Gebb J, Goldberg GL, Dar P
Subjects: Biomedical Science

The high sensitivity and specificity of the sequential endometrial aspiration at the time of sonohysterography make this approach a useful and reliable screening algorithm for detecting endometrial cancer or hyperplasia in postmenopausal women at risk. Endometrial aspiration at the time of sonohysterography should be considered as an initial one-stop endometrial evaluation in this population.

Cell

Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy.


Published: Aug 14, 2014 by Cell
Authors: Guo M, Ehrlicher AJ, Jensen MH, Renz M, Moore JR, Goldman RD, Lippincott-Schwartz J, Mackintosh FC, Weitz DA.
Subjects: Biomedical Science

Molecular motors in cells typically produce highly directed motion; however, the aggregate, incoherent effect of all active processes also creates randomly fluctuating forces, which drive diffusive-like, nonthermal motion. Here, we introduce force-spectrum-microscopy (FSM) to directly quantify random forces within the cytoplasm of cells and thereby probe stochastic motor activity.

Cytometry A

Fluorescence microscopy - a historical and technical perspective.


Published: Apr 12, 2013 by Cytometry A
Authors: Renz, M
Subjects: Biomedical Science

For a little more than a century, fluorescence microscopy has been an essential source of major discoveries in cell biology. Recent developments improved both visualization and quantification by fluorescence microscopy imaging and established a methodology of fluorescence microscopy. By outlining basic principles and their historical development, I seek to provide insight into and understanding of the ever-growing tools of fluorescence microscopy.

Proc Natl Acad Sci U S A

Plasticity of the asialoglycoprotein receptor deciphered by ensemble FRET imaging and single-molecule counting PALM imaging.


Published: Oct 30, 2012 by Proc Natl Acad Sci U S A
Authors: Renz M, Daniels BR, Vámosi G, Arias IM, Lippincott-Schwartz J.
Subjects: Biomedical Science

Here, we address this problem for the asialoglycoprotein receptor using ensemble FRET imaging, analytical modeling, and single-molecule counting with photoactivated localization microscopy (PALM).

Proc Natl Acad Sci U S A

Multiscale diffusion in the mitotic Drosophila melanogaster syncytial blastoderm.


Published: May 29, 2012 by Proc Natl Acad Sci U S A
Authors: Daniels BR, Rikhy R, Renz M, Dobrowsky TM, Lippincott-Schwartz J.
Subjects: Biomedical Science

Here, we characterize the effects of the geometry of the early syncytial Drosophila embryo on the effective diffusivity of cytoplasmic proteins. Our results demonstrate that the presence of transient mitotic membrane furrows results in a multiscale diffusion effect that has a significant impact on effective diffusion rates across the embryo.

Nat Methods

Probing protein heterogeneity in the plasma membrane using PALM and pair correlation analysis.


Published: Sep 18, 2011 by Nat Methods
Authors: Sengupta P, Jovanovic-Talisman T, Skoko D, Renz M, Veatch SL, Lippincott-Schwartz J.
Subjects: Biomedical Science

Combining pair-correlation analysis with PALM (PC-PALM), we provide a method to analyze complex patterns of protein organization across the plasma membrane without determination of absolute protein numbers.

J Am Chem Soc

Bright monomeric photoactivatable red fluorescent protein for two-color super-resolution sptPALM of live cells.


Published: May 12, 2010 by J Am Chem Soc
Authors: Subach FV, Patterson GH, Renz M, Lippincott-Schwartz J, Verkhusha VV.
Subjects: Biomedical Science

On the basis of monomeric TagRFP, we have developed a photoactivatable TagRFP protein that is initially dark but becomes red fluorescent after violet light irradiation.

Chromosome Res

Dynamics of the CapG actin-binding protein in the cell nucleus studied by FRAP and FCS.


Published: May 08, 2008 by Chromosome Res
Authors: Renz M, Langowski J.
Subjects: Biomedical Science

Since the nuclear CapG fraction seems to be pivotal to the increase in cell motility, we focused our studies on the CapG mobility in cell nuclei of live breast cancer cells. Using FCS and FRAP we showed that the eGFP-tagged CapG is monomeric and characterized its diffusional properties on the microsecond to minute timescale.

Int J Cancer

Invasive breast cancer cells exhibit increased mobility of the actin-binding protein CapG.


Published: Dec 04, 2007 by Int J Cancer
Authors: Renz M, Betz B, Niederacher D, Bender HG, Langowski J.
Subjects: Biomedical Science

Here, we examined the dynamical distribution of the CapG protein within the living cell, i.e. the import of the CapG protein into the nucleus. The nuclear import kinetics of invasive, metastasizing breast cancer cells were compared to the import kinetics of non-neoplastic cells similar to normal breast epithelium.