2nd Edition
Biomedical Photonics Handbook Biomedical Diagnostics
Shaped by Quantum Theory, Technology, and the Genomics Revolution
The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The second volume, Biomedical Diagnostics, focuses on biomedical diagnostic technologies and their applications from the bench to the bedside.
Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians
Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies.
What’s New in This Edition:
A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics and metabolomics allow sensing of early disease state biomarkers, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements, the second edition contains new topics and chapters including:
• Fiber Optic Probe Design
• Laser and Optical Radiation Safety
• Photothermal Detection
• Multidimensional Fluorescence Imaging
• Surface Plasmon Resonance Imaging
• Molecular Contrast Optical Coherence Tomography
• Multiscale Photoacoustics
• Polarized Light for Medical Diagnostics
• Quantitative Diffuse Reflectance Imaging
• Interferometric Light Scattering
• Nonlinear Interferometric Vibrational Imaging
• Multimodality Theranostics Nanoplatforms
• Nanoscintillator-Based Therapy
• SERS Molecular Sentinel Nanoprobes
• Plasmonic Coupling Interference Nanoprobes
Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and lists of references for further reading.
Biomedical Analysis, Sensing and Imaging
Biosensors for Medical Applications
Tuan Vo-Dinh, Leonardo Allain and Andrew Fales
Glucose Monitoring
Casey W. Pirnstill, Brian Cummins, Gerard L. Coté, Roger J. McNichols
Biochips and MicroArrays: Tools for the New Medicine
Tuan Vo-Dinh and G. D. Griffin
Atomic Spectroscopy for Biological and Clinical Analysis
Andrew Taylor
Flow Cytometry
Francis Mandy, Joe Trotter, Rudi Varro, Ming Yan, and Diether Recktenwald
Capillary Electrophoresis Techniques in Biomedical Analysis
S. Douglas Gilman and Michael J. Sepaniak
Surface Plasmon Resonance Imaging: Principle, Development, and Biomedical Applications
Julien Moreau, Jean-Pierre Cloarec, Paul Charette, Michel Goossens, Michael Canva, Tuan Vo-Dinh
Surface-Enhanced Raman Scattering (SERS) for Biomedical Diagnostics
Tuan Vo-Dinh and David L. Stokes
Functional Imaging with Diffusing Light
Arjun G. Yodh and David A. Boas
Molecular Contrast Optical Coherence Tomography
Oscar Carrasco-Zevallos, and Joseph Izatt
Multiscale Photoacoustic Microscopy and Macroscopy, Song Hu and Lihong V. Wang
Polarized light for Medical Diagnostics
Steven L. Jacques
X-Ray Diagnostic Techniques
Xizeng Wu, Molly. D. Wong, Abby E. Deans and Hong Liu
Optical Pumping and MRI of Hyperpolarized Spins
Xizeng Wu, Thomas Nishino and Hong Liu
Biomedical Diagnostics and Optical Biopsy
Fluorescence Spectroscopy for Biomedical Diagnostics
Tuan Vo-Dinh and Brian M. Cullum
Elastic-Scattering Spectroscopy and Diffuse Reflectance
Judith R. Mourant and Irving J. Bigio
Quantitative Diffuse Reflectance Imaging of Tumor Margins
Bing Yu, Nirmala Ramanujam
Near Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues
E.M. Sevick-Muraka, E. Kuwana, A. Godavarty, J.P. Houston, A.B. Thompson, R.Roy
Interferometric light scattering techniques for measuring nuclear morphology and detecting dysplasia
Yizheng Zhu, Francisco E. Robles, Neil G. Terry, and Adam Wax
Ultrasonically Modulated Optical Imaging
François Ramaz, Emmanuel Bossy, Michel Gross and A. Claude Boccara
Optoacoustic Tomography
Alexander A. Oraevsky and Alexander A. Karabutov
Raman Spectroscopy: From Benchtop to Bedside
Anita Mahadevan-JansenFourier Transform Infrared (FTIR) Microspectroscopic Methods for Biomedical Analyses: From Single Point Detection to Two-Dimensional Imaging
Rohit Bhargava and Ira W. Levin
Photon Migration Spectroscopy Frequency-Domain Techniques
Albert E. Cerussi and Bruce J. Tromberg
Biography
Tuan Vo-Dinh is the R. Eugene and Susie E. Goodson Distinguished Professor of biomedical engineering, professor of chemistry, and director of the Fitzpatrick Institute for Photonics at Duke University. He received a B.S. in physics in 1970 from EPFL (Ecole Polytechnique Federal de Lausanne) in Lausanne and a Ph.D. in physical chemistry in 1975 from ETH (Swiss Federal Institute of Technology) in Zurich, Switzerland. Dr. Vo-Dinh has authored over 350 publications in peer-reviewed scientific journals. He is the author of a textbook on spectroscopy and editor of 6 books. He has received numerous awards and holds over 37 U.S. and international patents.