1st Edition
Applications of Biophotonics and Nanobiomaterials in Biomedical Engineering
This book provides a link between different disciplines of nanophysics, biophotonics, nanobiomaterials & applications of nanobiophotonics in biomedical research and engineering. The fundamentals of light, matter, nanobiomaterials & nanophysics are discussed together, and relevant applications in biomedical engineering as well as other related factors influencing the interaction process are explicated. Theoretical and experimental research is combined, emphasizing the influence of crucial common factors on applications.
LIGHT AND MATTER
Basics of Quantum Physics
Language and knowledge
Causality and chance
Fundamentals of classical mechanics
Conceptual quantum physics
Ordinary Light
The nature and properties of ordinary light
Properties of chaotic light
A brief review of Fourier analysis
Fourier analysis and chaotic light
Spontaneous emission
Laser Basics
Introduction
Quantum theory of radiation
Structure and principles
Properties of laser light
Line broadening mechanisms
Origin of chaotic properties of laser light
Table of some laser systems
Matter
The structure and properties of matter
Mesoscopic forces
Free electrons in solids
NANOBIOPHOTONICS: BIOPHOTONICS AND NANOTECHNOLOGY
Fundamentals of Biology and Thermodynamics
Introductory biological concepts
Thermodynamics basics
Statistical mechanics and microstates
Biological complexity, chaos and fractal
Thermodynamics of cancer cells
A note on the philosophy of biological system
Biophotonics
Some definitions
Fundamentals of tissue optical properties and light transport
Laser-tissue interaction mechanisms
Laser-induced fluorescence spectroscopy
Laser-induced plasma breakdown spectroscopy
Nanotechnology
Introduction
Limitations and effects of small size
Material properties at nanoscale
NANOBIOMATERIALS
Biomaterials and surface modification
Introduction
Surface modification of biomaterials
Some examples of laser surface modification
Nanomaterials
Introduction
Iron-oxides
Metallic nanostructures
Polymeric
Dendrimers
Quantum dots
Upconversion nanoparticles
Nanotoxicity
NANOMEDICINE: APPLICATIONS OF BIOPHOTONICS AND NANOBIOMATERIALS
Laser-Tissue Soldering
Introduction
Application of albumin protein and indocyanine green chromophore for tissue soldering using IR diode laser: Ex-vivo and in-vivo studies
An in-vitro investigation of skin tissue soldering using gold nanoshells and diode laser
Enhanced laser tissue soldering using indocyanine green chromophore and gold nanoshells combination
Drug Delivery
Introduction
Evaluation of drug release from PLGA nanospheres containing bethametsone
Dynamic study of PLGA/CS nanoparticles delivery containing drug model into phantom tissue using CO2 laser for clinical applications
Early experimental results of thrombolysis using controlled release of tissue plasminogen activator encapsulated by PLGA/CS nanoparticles delivered by pulse 532 nm laser
Fabrication and characterization of magnetoplasmonic liposome carriers
Theranostic: Cancer Diagnosis and Therapy
Introduction
Theranostic nanomaterials
Hyperthermia
Applications
Biomedical imaging
Introduction
Single, multimodal imaging systems and contrast agents
Imaging agents and multifunctionality
Fluorescence microscopy (FM)
Photoacoustic (PA) and thermoacoustic (TA) imaging
Photoacoustic monitoring
Contrast-enhanced photoacoustic imaging
Biography
Professor Mohammad E. Khosroshahi received his Ph.D. degree in Applied Physics (Application of Lasers in Medicine) from Hull University (UK) in 1993, M.Sc in Analytical Physics from Swansea University (UK) in 1989 and B.Sc in Applied Physics and Electronics from Lancaster University (UK) in 1987. He joined the Biomaterial and Tissue Engineering group of Faculty of Biomedical Engineering at Amirkabir University of Technology (AUT) in Tehran where he is a Full Professor. He has been the Director of AUT Laser and Optics Research Center, Associate Dean of Research, Chair of Biomaterial Group, and Editor-in Chief of Iran Journal of Medical Laser. In 2013, he joined University of Toronto, Department of Mechanical & Industrial Engineering (MIE) as a Visiting Professor working on ‘’Contrast-enhanced photoacoustic imaging of cancer’’. His main research interests are: Biomedical optics, Nanobiophotonics, Nanostructures, Theranostic, Targeted drug delivery, Targeted laser cancer hyperthermia, Multifunctional photoacoustic drug delivery and bioimaging, Nanoferrofluidics, Biological chaos and Cancer thermodynamics. Professor Khosroshahi is member of Editorial Board of Journal of Nanomedicine and Nanotechnology, Fellow member of Institute of Nanotechnology, member of Canadian Association of Physics, Canadian Medical and Biological Engineering Society, American Association of Science &Technology, Optical Society of America and SPIE. He is author of 2 books, co-author of 2 book chapters, and has published over 85 peer reviewed papers in international journals and more than 100 conference papers. Recently he has been associated with the Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT) in MIE where he is currently teaching Application of Lasers in Engineering at graduate level. His research activities in the CADIPT encompass the development of an advanced nanoparticle-enhanced photoacoustic radar technology for early breast cancer tomographic imaging. Currently, Professor Khosroshahi is Director of Nanobiophotonics and Biomedical R&D Center at MIS-Electronics, Toronto.
