Vulnerability to Psychosis

From Neurosciences to Psychopathology

Edited by Paolo Fusar-Poli, Stefan J. Borgwardt, Philip McGuire

© 2012 – Psychology Press

196 pages | 8 Color Illus. | 2 B/W Illus.

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Hardback: 9781848720879
pub: 2012-02-20
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About the Book

Early clinical intervention in psychosis is now a major objective of mental health services and the development of specialist intervention services has greatly facilitated research on the early phases of this disorder.

In this book, contributors provide a review of the neurobiological research in people at high risk of psychosis, focusing on the transition from being at a high risk state to their first episode. Contributors consider unaffected family members and twin studies as well as the individual’s data before and after the onset of the illness. The environmental factors that contribute to a psychotic episode are also examined.

Vulnerability to Psychosis presents neurobiological findings in the context of what is now known about the psychopathology and cognitive impairments that are evident in people at high risk of psychosis. It will be essential reading for clinicians working with this client group, and will interest academics looking for state of the art information in this field.

Table of Contents

Borgwardt, Fusar-Poli, McGuire, Introduction. Broome, Dale, Marriott, Merino, Bortolotti, Neuroscience, Continua and the Prodromal Phase of Psychosis. Yung, Wood, Nelson, Defining the Risk for Psychosis: Can Neuroscience Help Psychopathology? Piccchioni, Toulopoulou, Genetic Determinants of the Vulnerability to Psychosis: Findings from Twin Studies. Day, Pariante, Stress and Cortisol in the Pre-psychotic Phases. Pukrop, Ruhrmann, Neurocognitive Indicators of High-risk States for Psychosis. Borgwardt, Fusar-Poli, Riecher- Rössler, McGuire, Grey Matters: Mapping the Transition to Psychosis. Fusar-Poli, Agosti, Borgwardt, Functional MRI in Prodromal Psychosis. Stone, Glutamate: Gateway to Psychosis? Howes, Does Dopamine Start the Psychotic "Fire"? Chrossley, Bramon, Neurophysiological Alterations in the Pre-psychotic Phases. Yang, Wonpat-Borja, Opler, Compton, Kelly, Purdie-Vaughns, Corcoran, Stigma in Early Stages of Psychotic Illness: Connections with Cognitive Neuroscience. McGuire, Conclusions.

About the Editors

Paolo Fusar-Poli is an honorary lecturer and a consultant in adult psychiatry at the Institute of Psychiatry, King's College, London.

Stefan Borgwardt is a psychiatrist, neuroscientist and professor of neuropsychiatry at the University of Basel, Switzerland.

Philip McGuire is a professor of psychiatry and cognitive neuroscience at the Institute of Psychiatry, King's College, London.

About the Series

Maudsley Series

Henry Maudsley, founder of the Maudsley Hospital, was the most prominent English psychiatrist of his generation.

The Maudsley Hospital was united with the Bethlem Royal Hospital in 1948 and its medical school renamed the Institute of Psychiatry. It is now entrusted with the duty of advancing psychiatry by teaching and research. The South London and Maudsley (SLAM) NHS Trust, together with the Institute of Psychiatry, are jointly known as The Maudsley.

The monograph series reports work carried out at The Maudsley. Some of the monographs are directly concerned with clinical problems; others, less obviously relevant, are in scientific fields that are cultivated for the furtherance of psychiatry.

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Subject Categories

BISAC Subject Codes/Headings:
PSY007000
PSYCHOLOGY / Clinical Psychology
PSY036000
PSYCHOLOGY / Mental Health