Adverse Drug Interactions: A Handbook for Prescribers, Second Edition, 2nd Edition (Paperback) book cover

Adverse Drug Interactions

A Handbook for Prescribers, Second Edition, 2nd Edition

Edited by Lakshman Delgoda Karalliedde, Simon Clarke, Ursula Gotel nee Collignon, Janaka Karalliedde

CRC Press

1,089 pages | 2 B/W Illus.

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Description

Adverse Drug Interactions: A Handbook for Prescribers assists clinicians byproviding key information on potential adverse effects that can result from prescribing two or more drugs for simultaneous use.

Interactions that are likely to give rise to life-threatening conditions, and which must therefore be completely avoided, are clearly highlighted. Less threatening but nonetheless important interactions necessitating practical measures, such as frequent monitoring and advice to patients, are also discussed.

Presented in a user-friendly format, the book is organised by drug class and provides a brief summary of the mechanism underlying a particular interaction, alternative drugs lacking the same reactions that may be considered, and instructions for monitoring patients when adverse effects occur.

All interactions listed in the previous edition have been reviewed and updated using the latest information available. The clinical reality of the widespread use of potent medicines, whether allopathic, herbal or traditional, has led to the inclusion of a chapter specifically addressing over-the-counter drugs and remedies.

Importantly, the increasing relevance of drug interactions due to genetic polymorphisms of metabolizing enzymes and drug transporters and the associated influence of these in ethnic groups is discussed. Also discussed is the risk of interactions in many vulnerable population groups (e.g. infancy, pregnancy, infections, liver and kidney disease).

This quick and easy reference guide brings together the current evidence base with a broad range of practical prescribing experience to produce a source of advice that can be used in the clinic, pharmacy, or at the patient’s bedside.

Reviews

“There is much to commend. There are useful preliminary sections on the complexity of drug–drug interactions and the emerging role of electronic decision support systems… I was particularly pleased to see the inclusion of interactions with herbal and common over-the-counter medications, alcohol, ‘classic’ recreational drugs, vitamins and minerals, and key food groups.”—Daniel Marks, University College London Hospital, London, British Journal of Hospital Medicine

Table of Contents

Drugs Acting on the Cardiovascular System

Simon F.J. Clarke

Drugs Acting on the Central Nervous System

Lakshman Delgoda Karalliedde and Harini Genegedera

Anticancer and Immunomodulating Drugs

Patrick Yong

Anticoagulants

Rebecca Chanda

Antidiabetic Drugs

Yohan P. Samarasinghe and Janaka Karalliedde

Other Endocrine Drugs

Ming Ming Teh and Yohan P. Samarasinghe

Analgesics

Ruwan Parakramawansha

Musculoskeletal Drugs

Winglam Yeung

Anesthetic Drugs: General

Vasanthi Pinto and E. Queenie Veerasingam

Drugs to Treat Infections

Ursula Collignon

Drugs Acting on the Gastrointestinal Tract

Ursula Collignon

Respiratory Drugs

Lakshman Delgoda Karalliedde and Simon F.J. Clarke

Metabolic Drugs

Simon F.J. Clarke

Obstetrics and Gynecology

Gregory Ian Giles and Simon F.J. Clarke

Drugs Used to Treat the Urinary System

Simon F.J. Clarke

Drugs of Abuse

Lakshman Delgoda Karalliedde and Janaka Karalliedde

Miscellaneous

Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

Over-the-Counter/Online Drugs, Traditional and Herbal Remedies

Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

Appendices:

Factors Associated with Drug Effects

Simon F.J. Clarke, Lakshman Delgoda Karalliedde, and Ursula Collignon

Factors Associated with Interactions (Polymorphisms, Ethnicity, Age, Disease States)

Simon F.J. Clarke, Lakshman Delgoda Karalliedde, and Ursula Collignon

Foods Implicated in Potentially Severe Interactions

Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

Clinical Drug Development

Lakshman Delgoda Karalliedde and Janaka Karalliedde

Assessments of Manifestations of DDIs

Simon F.J. Clarke and Ursula Collignon

Triptan Sensations

Lakshman Delgoda Karalliedde and Janaka Karalliedde

Assessment of Severity of Liver Disease

Chulananda Goonasekera

Prescribing Guidelines for Elderly Patients

Andrea Corsonello and Giuseppe Maltese

Factors Affecting Efficacy of Anti-Infective Agents

Niroshini Manthri Giles and Lakshman Delgoda Karalliedde

Assessments of Obesity

Lakshman Delgoda Karalliedde and H.M.U. Amila Jayasinghe

About the Editors

Edited by

Lakshman Delgoda Karalliedde, visiting professor, Faculty of Medicine Peradeniya, Sri Lanka, and visiting senior lecturer, King’s College London, UK

Simon Clarke, Frimley Park NHS Foundation Trust, Camberley, UK

Ursula Gotel nee Collignon, St. Thomas' Hospital, London, UK

Janaka Karalliedde, King's College London School of Medicine, UK

Subject Categories

BISAC Subject Codes/Headings:
MED000000
MEDICAL / General
MED071000
MEDICAL / Pharmacology
MED072000
MEDICAL / Pharmacy
MED096000
MEDICAL / Toxicology