Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.
Table of Contents
Relationship Between Airway Wall Thickness and Airway Hyperresponsiveness, A.L. James
Airway Wall Remodelling in the Pathogenesis of Asthma: Cytokine Expression in the Airways, P. Bradding, A.E. Reddington, and S.T. Holgate
Inflammation and Cytokines in Airway Wall Remodelling, J.W. Wilson and X. Li
Fibrogenic Cytokines in Airway Fibrosis, X. Li and J.W. Wilson
Epithelial Function and Airway Responsiveness, R.G. Goldie and J.M.H. Preuss
Heparin and Related Molecules: Antiproliferative and Anti-inflammatory Effects in the Airways, S.A.Kilfeather and C. Page
In Vivo Models of Smooth Muscle Growth, J.G. Martin and T.R. Bai
Relationship Between Smooth Muscle Shortening and Resistance in Isolated Airways, H.W. Mitchell, P.K. McFawn, J.C. Marriott, and M.P. Sparrow
Assessment of Airway Smooth Muscle Growth and Division: In Vitro Studies, S.J. Hirst
Regulation of Growth of Airway Smooth Muscle by Second Messenger Systems, R.A. Panettieri, Jr.
Regulation of Airway Smooth Muscle Proliferation by b2-Adrenoceptor Agonists, A.G. Stewart, P.R. Tomlinson, and L. Schachte