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Handbooks in Pharmacology and Toxicology


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PARP as a Therapeutic Target

PARP as a Therapeutic Target

1st Edition

Edited By Jei Zhang
March 06, 2002

Recent research in cell death mechanisms has rekindled interest in PARP's (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors' dual ...

Molecular Bases of Anesthesia

Molecular Bases of Anesthesia

1st Edition

Edited By Eric Moody, Phil Skolnick
December 28, 2000

Molecular Bases of Anesthesia provides a clear overview of the state of knowledge about anesthetic mechanisms at the molecular level of occurrence and focusing on the latest state-of-the-art techniques that relate to how anesthetic drugs cause unconsciousness. With contributions by leading experts,...

Cell Death The Role of PARP

Cell Death: The Role of PARP

1st Edition

Edited By Csaba Szabo
June 22, 2000

Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in ...

Neurotransmitter Receptors in Actions of Antipsychotic Medications

Neurotransmitter Receptors in Actions of Antipsychotic Medications

1st Edition

Edited By Michael S. Lidow
June 22, 2000

Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a ...

Handbook of Alcoholism

Handbook of Alcoholism

1st Edition

Edited By Gerald Zernig, Alois Saria, Martin Kurz, Stephanie O'Malley
March 24, 2000

While the war on drugs continues to attract world attention, it is often overlooked that alcoholism remains a major worldwide health concern. No matter what your expertise, the CRC Handbook of Alcoholism can help you acquire the necessary skills to treat problem drinkers and alcohol-dependent ...

Manual of Immunological Methods

Manual of Immunological Methods

1st Edition

By Canadian Networking
July 02, 1998

The Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be ...

Pharmacology of Antimuscarinic Agents

Pharmacology of Antimuscarinic Agents

1st Edition

By Laszlo Gyermek
November 25, 1997

The theoretical and practical significance of antimuscarinic drugs is more obvious today than ever before. Antimuscarinics have helped to explore the pathomechanisms of of Alzheimer's disease, and to treat the symptoms of Parkinson's, cardiovascular problems, gastrointestinal diseases, and even ...

Anabolic Treatments for Osteoporosis

Anabolic Treatments for Osteoporosis

1st Edition

Edited By James F. Whitfield, Paul Morley
October 20, 1997

Osteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at ...

Muscarinic Receptor Subtypes in Smooth Muscle

Muscarinic Receptor Subtypes in Smooth Muscle

1st Edition

Edited By Richard M. Eglen
January 21, 1997

This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary ...

Airway Wall Remodelling in Asthma

Airway Wall Remodelling in Asthma

1st Edition

By A. G. Stewart
September 24, 1996

Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma...

Chemoattractant Ligands and Their Receptors

Chemoattractant Ligands and Their Receptors

1st Edition

By Richard Horuk
August 14, 1996

Chemoattractant Ligands and Their Receptors succinctly summarizes cutting-edge research in the important area of chemoattraction in immunology. It explains how chemoattractant molecules mobilize immune cells to ward off attack by invading pathogens, both at a molecular and at a cellular level. ...

Pharmacological Effects of Ethanol on the Nervous System

Pharmacological Effects of Ethanol on the Nervous System

1st Edition

Edited By Richard A. Deitrich, V. Gene Erwin
December 21, 1995

This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on ...

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