Taxol: Science and Applications, 1st Edition (Hardback) book cover


Science and Applications, 1st Edition

Edited by Matthew Suffness

CRC Press

448 pages

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Hardback: 9780849383823
pub: 1995-05-25
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This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.


"…a marvelous job of assembling a cast of contributors who have excelled in bringing to full light the developmental hurdles a natural product can face en route to market and in highlighting the efforts and research strategies employed in attempts to surmount those barriers."

-Dolatrai M. Vyas, J. Nat. Prod., 1996, 59, 216-218

Table of Contents


Discovery and Development of TAXOL®, M. Suffness and M.E. Wall

Yew and Us: A Brief History of the Yew Tree. H.R. Hartzell, Jr.

Supply of TAXOL®

Taxus for TAXOL® and Taxoids, E.M. Croom, Jr.

Potential of Plant Cell Culture for Taxane Production, D.M. Gibson, R.E.B. Ketchum, T.J. Hirasuna, and M.L. Shuler

Semisynthesis of TAXOL® and Taxotere, R.A. Holton, R.J. Biediger, and P. Douglas Boatman

Toward the Total Synthesis of TAXOL® and Its Analogues, P.A. Wender, M.G. Natchus, and A.J. Shuker

Biology of TAXOL®

Biosynthesis of TAXOL®, H.G. Floss and U. Mocek

Preclinical Antitumor Activity of Taxanes, W.C. Rose

Biopharmaceutics of Paclitaxel (TAXOL®): Formulation, Activity, and Pharmacokinetics, R.M. Straubinger

The Use of TAXOL® in Cell Biology, R.B. Vallee

Chemistry of TAXOL®

Detection and Isolation, K.M. Snader

Natural Taxoids: Structure and Chemistry, D.G.I. Kingston

The Medicinal Chemistry of TAXOL® , G.I. Georg, T.C. Boge, Z.S. Cheruvallath, J.S. Clowers, G.C.B. Harriman, M. Hepperie, and H. Park

Clinical Studies

TAXOL® : Clinical Results and Current Issues in Development, S.G. Arbuck and B.A. Blaylock


About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
MEDICAL / Pharmacology