Molecular Bases of Anesthesia: 1st Edition (Hardback) book cover

Molecular Bases of Anesthesia

1st Edition

Edited by Eric Moody, Phil Skolnick

CRC Press

330 pages

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pub: 2000-12-28
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Description

Molecular Bases of Anesthesia provides a clear overview of the state of knowledge about anesthetic mechanisms at the molecular level of occurrence and focusing on the latest state-of-the-art techniques that relate to how anesthetic drugs cause unconsciousness.

With contributions by leading experts, this timely book includes chapters on how to evaluate theories of anesthesia in general and includes discussion of some of the techniques, such as genetics, that can be used to address problems. Also discussed are anesthetic actions at major brain targets with a special emphasis on ion channels and areas of controversy in the field.

This reference provides a broad survey of anesthetic actions, including hyperbaric pressure and anesthesia; volatile anesthetic interactions with proteins; and structure activity relationships of volatile anesthetics. Molecular Bases of Anesthesia stands alone as an in-depth, authoritative guide.

Reviews

"Moody and Skolnick have produced a timely and valuable summary of progress in this field… this book is heartily recommended to anyone with an interest in how volatile anesthetics work (this should include the majority of anesthetists). A particular strength of this monograph is that it is focused and short enough to be accessible to many nonresearchers. Yet it also delves deeply enough into its subject to make it a valuable reference to scientists who work on anesthetic mechanisms…. A few comprehensive reference books have attempted to summarize the field, but there is a paucity of shorter, well-written summaries focused on different aspects of this broad question. Moody and Skolnick's Molecular Bases of Anesthesia begins to address this need by organizing current knowledge and suggesting future research directions."

-Anesthesia & Analgesia, September 2001

"This textbook is recommended to nurse anesthetists who wish to review and update their knowledge on a mysterious group of drugs that are administered daily."

-AANA Journal, vol. 69, no. 6, December 2001

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Table of Contents

BASIC PHARMACOLOGY OF VOLATILE ANESTHETICS

James P. Dilger

EXPERIMENTAL APPROACHES TO THE STUDY OF VOLATILE ANESTHETIC-PROTEIN INTERACTIONS

Jonas S. Johannsson and Roderic G. Eckenhoff

PRESSURE AND ANESTHESIA

Stephen Daniels

GENETICS AND ANESTHETIC MECHANISMS

Philip G. Morgan and Margaret M. Sedensky

STRUCTURE-ACTIVITY RELATIONSHIPS OF INHALED ANESTHETICS

Donald D. Koblin

VOLATILE ANESTHETIC EFFECTS ON CALCIUM

CHANNELS

Hugh C. Hemmings, Jr.

INHALATION ANESTHETIC EFFECTS ON NEURONAL PLASMA MEMBRANE CA2+ -ATPase

Piotr K. Janicki

ANESTHETIC MODIFICATIONS OF NEURONAL SODIUM AND POTASSIUM CHANNELS

Daniel S. Duch and Tatyana N. Vysotskaya

VOLATILE ANESTHETIC EFFECTS AT EXCITATORY AMINO RECEPTORS

Jo Ellen Dildy-Mayfield and R. Adron Harris

EFFECTS OF VOLATILE ANESTHETICS ON GABAA RECEPTORS: ELECTRICOPHYSIOLOGIC STUDIES

Robert A. Pearce

NEUROCHEMICAL ACTIONS OF ANESTHETICS AT THE GABAA RECEPTORS

Eric J. Moody and Phil Skolnick

STEREOSELECTIVE ACTIONS OF VOLATILE ANESTHETICS

Phil Skolnick and Eric J. Moody

EFFECTS OF VOLATILE ANESTHETICS AT NICOTINIC ACETYLCHOLINE RECEPTORS

Pamela Flood

INDEX

About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
MED006000
MEDICAL / Anesthesiology
MED071000
MEDICAL / Pharmacology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology