1st Edition

Molecular Bases of Anesthesia




ISBN 9780849385551
Published December 28, 2000 by CRC Press
330 Pages

USD $325.00

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Book Description

Molecular Bases of Anesthesia provides a clear overview of the state of knowledge about anesthetic mechanisms at the molecular level of occurrence and focusing on the latest state-of-the-art techniques that relate to how anesthetic drugs cause unconsciousness.

With contributions by leading experts, this timely book includes chapters on how to evaluate theories of anesthesia in general and includes discussion of some of the techniques, such as genetics, that can be used to address problems. Also discussed are anesthetic actions at major brain targets with a special emphasis on ion channels and areas of controversy in the field.

This reference provides a broad survey of anesthetic actions, including hyperbaric pressure and anesthesia; volatile anesthetic interactions with proteins; and structure activity relationships of volatile anesthetics. Molecular Bases of Anesthesia stands alone as an in-depth, authoritative guide.

Table of Contents

BASIC PHARMACOLOGY OF VOLATILE ANESTHETICS
James P. Dilger
EXPERIMENTAL APPROACHES TO THE STUDY OF VOLATILE ANESTHETIC-PROTEIN INTERACTIONS
Jonas S. Johannsson and Roderic G. Eckenhoff
PRESSURE AND ANESTHESIA
Stephen Daniels
GENETICS AND ANESTHETIC MECHANISMS
Philip G. Morgan and Margaret M. Sedensky
STRUCTURE-ACTIVITY RELATIONSHIPS OF INHALED ANESTHETICS
Donald D. Koblin
VOLATILE ANESTHETIC EFFECTS ON CALCIUM
CHANNELS
Hugh C. Hemmings, Jr.
INHALATION ANESTHETIC EFFECTS ON NEURONAL PLASMA MEMBRANE CA2+ -ATPase
Piotr K. Janicki
ANESTHETIC MODIFICATIONS OF NEURONAL SODIUM AND POTASSIUM CHANNELS
Daniel S. Duch and Tatyana N. Vysotskaya
VOLATILE ANESTHETIC EFFECTS AT EXCITATORY AMINO RECEPTORS
Jo Ellen Dildy-Mayfield and R. Adron Harris
EFFECTS OF VOLATILE ANESTHETICS ON GABAA RECEPTORS: ELECTRICOPHYSIOLOGIC STUDIES
Robert A. Pearce
NEUROCHEMICAL ACTIONS OF ANESTHETICS AT THE GABAA RECEPTORS
Eric J. Moody and Phil Skolnick
STEREOSELECTIVE ACTIONS OF VOLATILE ANESTHETICS
Phil Skolnick and Eric J. Moody
EFFECTS OF VOLATILE ANESTHETICS AT NICOTINIC ACETYLCHOLINE RECEPTORS
Pamela Flood
INDEX

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Reviews

"Moody and Skolnick have produced a timely and valuable summary of progress in this field... this book is heartily recommended to anyone with an interest in how volatile anesthetics work (this should include the majority of anesthetists). A particular strength of this monograph is that it is focused and short enough to be accessible to many nonresearchers. Yet it also delves deeply enough into its subject to make it a valuable reference to scientists who work on anesthetic mechanisms.... A few comprehensive reference books have attempted to summarize the field, but there is a paucity of shorter, well-written summaries focused on different aspects of this broad question. Moody and Skolnick's Molecular Bases of Anesthesia begins to address this need by organizing current knowledge and suggesting future research directions."
-Anesthesia & Analgesia, September 2001

"This textbook is recommended to nurse anesthetists who wish to review and update their knowledge on a mysterious group of drugs that are administered daily."
-AANA Journal, vol. 69, no. 6, December 2001


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