Over thiry-five experts contribute to this publication about the various interactions and interrelationships of the parameters which affect the normal and ischemic heart. Mechanical aspects related to the global and regional function of the heart are discussed. Coronary perfusion of the ischemic heart is considered, with emphasis on the effects of reperfusion. Electrical activation, formation of arrhythmias, and the effects of ischemia or ionic transport in the myocardium are presented. Metabolic aspects of the ischemic heart, including calcium transport, are also explained.
Table of Contents
CARDIAC MECHANICS. Computer Interactive Methods of Measuring Regional Left Ventricular Dysfunction in Isolated Disease of the Left Anterior Descending Coronary Artery. Electrical and Mechanical Mapping of the Left Ventricular Free Wall During Normoxia and Regional Myocardial Ischemia - The Effect of Electrical Stimulation. Left Ventricular Pressure-Volume Relationships in Patients Measured with the Conductance Catheter and Inferior Vena Caval Balloon Occlusion. Influence of Altered Extent of Regional Ischemia on in situ End-Systolic Pressure-Volume Relationships. Regional Ventricular Function in Pulsus Alternans. Functional Reversibility of an Infarct Determined by Segmental Shortening Measurements. Ventriculoarterial Matching in Exercising Dogs. Three-Dimensional Analysis of Left Ventricular Geometry of the Normal and Abnormal Heart. FORMATION OF ARRHYTHMIA. The Sequence and Mechanisms of Ventricular Arrhythmia in Acute Myocardial Ischemia and Reperfusion - An Introduction. The Arterially Perfused Rabbit Papillary Muscle: A Model to Study Electrical Properties in Myocardial Ischemia. Alpha Adrenergic Modulation of Impulse Initiation in Normal and Ischemic Cardiac Fibers. CONDUCTION AND ACTIVATION. Ischemic Inhibition of Calcium Slow Current in the Heart. Three-Dimensional Simulation Model of the Electrical Activation Patterns in the Ischemic Heart. Aberrant Conduction Patterns in and Around an Ischemic Zone by a Finite Element Model. Prevalence and Prognostic Significance of Ventricular Ectopic Activity in Coronary Artery Disease. PERFUSION AND REPERFUSION. Use of Venous Pressure as a Probe for Waterfall-Like Behavior in the Coronary Bed. Flow Patterns During Acute Coronary Ischemia and Coronary Sinus Occlusion: A Window to the Mechanisms of "Hidden" Myocardial Perfusion. Reversal of Coronary Blood Flow by Intrathoracic Pressure Variations. Central Neural Aspects of Coronary Flow Regulation. Prediction of Dynamic Transcapillary Pressure Difference in the Coronary Circulation. Three-Dimensional Coronary Anatomy and Myocardial Perfusion - An Overview of Results with the Dynamic Spatial Reconstructor. The No-Reflow Phenomenon: A Misnomer? Evaluating Coronary Stenoses: What Arteriograms and Flow Measurements Can and Cannot Tell Us. TRANSPORT AND METABOLISM. Role of Beta Adrenoceptors in the Control of Myocardial Oxygen Supply/Consumption Heterogeneity. The Delivery of Oxygen to the Myocardium. Impairment of Lipid Metabolism in Ischemia and Reperfused Myocardial Tissue. Magnetic Resonance Spectroscopy for Evaluation of Myocardial Ischemia. Fractal Approaches to Myocardial Flows. Relation Between Contraction and Metabolic Efficiency. Interdependence Between Cardiac Function, Oxygen Demand, and Supply. Calcium Metabolism in Enzymatically Dissociated Rat Heart Cells and in Intact Perfused Ferret Hearts. The Nature of Interaction Between Myocardial Tissue and Intramyocardial Coronary Vessel in the Contracting Heart. GENERAL DISCUSSION. Electrophysiological and Electrochemical Aspects. Perfusion, Reperfusion, and Circulation. Some Metabolic Aspects. Some Mechanical Aspects. CONCLUDING REMARKS. Index.