Analysis of Growth Factor Signaling in Embryos: 1st Edition (Hardback) book cover

Analysis of Growth Factor Signaling in Embryos

1st Edition

Edited by Malcolm Whitman, Amy Sater

CRC Press

435 pages | 14 Color Illus. | 32 B/W Illus.

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pub: 2006-08-15
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Developmental biologists have been driven to investigate growth factor signaling in embryos in order to understand the regulatory mechanisms underlying a given developmental process. Thus, it is critical to explore the technical methods and experimental designs for growth factor signaling in embryos.

Focusing on specific pathways or pathway components, Analysis of Growth Factor Signaling in Embryos provides the methods and guidelines for experimental design to study major aspects of cell signaling in vertebrate embryos. The book covers a broad range of topics in signaling and a variety of current model organisms. Section I explores specific signaling pathways or pathway components. In this section, some chapters highlight the biochemistry of signaling pathways during development, which is often distinctive from that observed in cell culture systems. Section II discusses ionic regulatory mechanisms and the two chapters in Section III examine ways of investigating gene regulation in response to extracellular signals. Finally, Section IV addresses emerging strategies that facilitate integrated analyses of cell signaling in vivo in embryonic systems.

Featuring contributions from expert researchers, Analysis of Growth Factor Signaling in Embryos will provide a foundation for further explorations of the cellular regulatory mechanisms governing vertebrate embryonic development.

Table of Contents


Analysis of Canonical Wnt Signaling in Xenopus Embryos

Wilson K. Clements and David Kimelman

How to Assay Non-Canonical Wnt Signaling: A Critical Analysis

Michael Kühl and Randall T. Moon

Regulation of TGF-β Family Activity by Proprotein Processing

Shailaja Sopory and Jan L. Christian

Analysis of MAP Kinase Pathways in Vertebrate Development

Amy K. Sater and Heithem M. El-Hodiri

Analysis of Retinoid Signalling in Embryos

Malcolm Maden

Wnt Signaling via the Rho Family of GTPases during Embryonic Development

Raymond Habas and Xi He

Phosphospecific Antibodies as Tools for the Study of Signal

Transduction during Development

Malcolm Whitman


Dynamic Analysis of Calcium Signaling in Animal Development

Diane C. Slusarski

Strategies and Techniques for Investigation of Biophysical Signals in Patterning

D.S. Adams and M. Levin


Expression Profiling in Xenopus Embryos

Curtis Altmann

Chromatin Immunoprecipitation for in vivo Studies of

Transcriptional Regulation during Development

Daniel R. Buchholz, Bindu D. Paul, and Yun-Bo Shi


Chemical Biology in Zebrafish Vascular Development

Joanne Chan and Thomas M. Roberts

Investigating Gastrulation

Karen Symes

Bringing Small Molecule Regulation of Protein Activity to

Developmental Systems

Karen J. Liu, Jason E. Gestwicki, and Gerald R. Crabtree

Systems Analysis of Signaling Pathways

Gregory R. Hoffman, Kevin Brown, Adrian Salic, and Ethan Lee


About the Series

Methods in Signal Transduction Series

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Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / Cytology
SCIENCE / Research & Methodology
SCIENCE / Life Sciences / Biology / Developmental Biology