The concept of signal transduction is now long established as a central tenet of biological sciences. Since the inception of the field close to fifty years ago, the number and variety of signal transduction pathways, cascades and networks have steadily increased and now constitute what is often regarded as a bewildering array of mechanisms by which cells sense and respond to extracellular and intracellular environmental stimuli. It is not an exaggeration to state that virtually every cell function is dependent on the detection, amplification and integration of these signals. Moreover, there is increasing appreciation that in a many disease states, aspects of signal transduction are critically perturbed.
Our knowledge of how information is conveyed and processed through these cellular molecular circuits and biochemical switches has increased enormously in scope and complexity since this series was initiated fifteen years ago. Such advances would not have been possible without the supplementation of older technologies, drawn chiefly from cell and molecular biology, biochemistry, physiology and pharmacology, with newer methods that make use of sophisticated genetic approaches as well as structural biology, imaging, bioinformatics and systems biology analysis.
The overall theme of this series continues to be the presentation of the wealth of up to date research methods applied to the many facets of signal transduction. Each volume is assembled by one or more editors who are pre-eminent in their specialty. In turn, the guiding principle for editors is to recruit chapter authors who will describe procedures and protocols with which they are intimately familiar in a reader-friendly format. The intent is to assure that each volume will be of maximum practical value to a broad audience, including students and researchers just entering an area, as well as seasoned investigators.
Open Access makes published academic research freely and permanently available online for anyone, anywhere. OA publications are downloaded 7 times more often, cited 50% more, and mentioned online 10 times more often. Upon publication, OA content is made available in digital format to read and download under a Creative Commons license.
Options are available to editors, authors and contributors to the series. See https://www.routledge.com/our-products/open-access-books/taylor-francis-oa-books for more information and frequently asked questions with respect to these options or contact Chuck Crumly, Senior Acquisitions Editor, at [email protected] for more details.
Ion and Molecule Transport in Lysosomes
New Techniques for Studying Biomembranes
Polycystic Kidney Disease
Signal Transduction and Smooth Muscle
Autophagy and Signaling
Calcium Entry Channels in Non-Excitable Cells
Gap Junction Channels and Hemichannels
Cyclic Nucleotide Signaling
Edited By Qingchun Tong
May 21, 2021
This book focuses on neuron signaling in the regulation of metabolism and body weight, and especially on methods used in these studies. Obesity and related metabolic syndromes have reached epidemic status, but still are no effective strategies for prevention and treatment. Body weight homeostasis ...
Edited By Bruno Gasnier, Michael X. Zhu
June 02, 2020
Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and ...
Edited By Qiu-Xing Jiang
March 18, 2020
New Techniques for Studying Biomembranes describes some of the latest methods used to investigate the dynamic distribution of specific lipids in membranes and their effects on other membrane components. The contributors present important discoveries with respect to lipid analysis and lipid ...
By Jinghua Hu, Yong Yu
November 14, 2019
This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of ...
Edited By Mohamed Trebak, Scott Earley
September 11, 2018
All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of...
Edited By Esther Wong
September 14, 2017
Autophagy and Signaling is an up-to-date overview of the many signaling pathways regulating autophagy in response to different cellular needs. Discussion includes the status and future directions of autophagy signaling research with respect to different aspects of health and disease. These include ...
Edited By Eric J. Murphy, Eric Murphy, Thad Rosenberger, Thad A. Rosenberger
September 12, 2017
As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade’s worth of advances in ...
Edited By Michael X. Zhu
September 12, 2017
The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic ...
Edited By Juliusz Ashot Kozak, James W. Putney, Jr.
July 14, 2017
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium...
Edited By Jonathan Soboloff, Dietmar J. Kappes
March 09, 2017
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume...
Edited By Donglin Bai, Juan C. Sáez
August 18, 2016
Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and ...
Edited By Xiaodong Cheng
May 12, 2015
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new ...