1st Edition

Opsin-free Optogenetics Technology and Applications

Edited By Yubin Zhou, Kai Zhang Copyright 2023
202 Pages 71 Color Illustrations
by CRC Press

202 Pages 71 Color Illustrations
by CRC Press

Optogenetics represents a breakthrough technology capable of dynamically modulating molecular and cellular activity in live cells with high precision. This transformative technology made it possible to reversibly interrogate protein actions, cellular events, and animal behaviors with a simple flash of light. Manipulating the temporal and spatial profile of light enabled precise control of... Read more

Table of Content

Chapter 1

Optogenetic dissection of a two-component calcium influx pathway

Xiaoxuan Liu, Yingshan Wang, Yubin Zhou, and Guolin Ma*

Chapter 2

High-throughput engineering of a light-activatable Ca2+ channel

Lian He*, Liuqing Wang, and Youjun Wang*

Chapter 3

Optogenetic activation of TrkB signaling

Peiyuan Huang, Zhihao Zhao, Lei Lei, and Liting Duan*

Chapter 4

Spatiotemporal modulation of neural repair

Huaxun Fan, Qin Wang, Kai Zhang*, and Yuanquan Song*

Chapter 5

Optogenetic control of neural stem cell differentiation

Yixun Su, Taida Huang, Kai Zhang, and Chenju Yi*

Chapter 6

An optogenetic toolbox for remote control of programmed cell death

Ningxia Zhang and Ji Jing*

Chapter 7

Control of protein levels in Saccharomyces cerevisiae by optogenetic modules that act on protein synthesis and stability

Sophia Hasenjäger, Jonathan Trauth, and Christof Taxis*

Chapter 8

Optogenetics as a tool to study neurodegeneration and signal transduction

Prabhat Tiwari* and Nicholas S. Tolwinski*

Chapter 9

Opsin-free optogenetics: brain and beyond

Jongryul Hong, Yeonji Jeong, and Won Do Heo*

Chapter 10

Constructing a far-red light-induced split-Cre recombinase system for controllable genome engineering

Meiyan Wang, Jiali Wu, and Haifeng Ye*

Chapter 11

Tools and Technologies for Wireless and Non-invasive Optogenetics

Guangfu Wu, Vagif Abdulla, Yiyuan Yang, Michael Schneider, and Yi Zhang*

Biography

Yubin Zhou, Kai Zhang

“This book differs markedly from these other, more general volumes by virtue of its concentration on next generation, non-opsin photo-switches. The result is a focused, highly informative, yet compact and easy-to-read volume that offers a model for how these works should be constructed.”

Doody Review Peter J. Kennelly, PhD (Virginia Tech)