The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.
Key Features
- Highlights the role the lungs play as an interface between the body and the environment
- Describes the underlying mechanism of lung diseases
- Emphasizes the ways nutrition contributes to lung health as well as the ways pollution adversely affect lung function
- Includes contributions from leading researchers
Chapters 8 and 13 of this book are available for free in PDF format as Open Access from the individual product page at www.routledge.com. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.
Editor Biography
List of Contributors
Preface
Yutong Zhao
Acknowledgement
Part I: Lung Health and Pulmonary Diseases
Chapter 1 Antimicrobial Peptides in Lung Health and Pulmonary Diseases
Jenna M. Kuhn and Yuanpu Peter Di
Chapter 2 Alveolar Epithelium in Lung Injury and Repair
SeungHye Han
Chapter 3 Environmental Toxicants in Lung Diseases
Samuel J. Cochran, Evangeline Schott, Brett Saunders, and Kymberly M. Gowdy
Chapter 4 Epigenetic Modifications of Histone in Lung Fibrosis
Yan Y. Sanders
Chapter 5 Translational Potential of Hypoxia-inducible factor-2α Signaling in Pulmonary Hypertension
Zhiyu Dai
Part II: Research Strategies and Methods in Lung Biology and Pathophysiology
Chapter 6 Utility of Lung Organoids to Accelerate Our Understanding of Human Pulmonary Development and Diseases
Nicole Pek and Mingxia Gu
Chapter 7 Establishment of Animal Models of Pulmonary Fibrosis
Maolin Yao, Mo Chen, and Lian Li
Chapter 8 Research Strategies for Investigating Protein Ubiquitination in Lung Diseases
Yutong Zhao
Chapter 9 Peroxidative Metabolism of Lung Lipids in Pulmonary Health and Disease: Emphasis on Methods of Analysis of Oxidative Modification of Polyunsaturated Membrane Phospholipids
Austin C. Elliott, Lasya Kopuri, Surya Narla, Patrick J. Oliver, Anita Yenigalla, Elliott D. Crouser, Krishna Rao Maddipati, Thomas J. Hund, Narasimham L. Parinandi
Part III: Pathogenesis and Therapies of COVID-19
Chapter 10 Renin-Angiotensin System (RAS) and COVID-19: Exploring the Impact, Inhibition, and Treatment Strategies
Qing Lin and Hongpeng Jia
Chapter 11 COVID-19 Therapeutics: Challenges and Opportunities
Travis B. Lear, Bill B. Chen, and Yuan Liu
Chapter 12 Clinical manifestations and pathogenesis of COVID-19 pulmonary disease
Moemen Eltobgy, Finny Johns, and Joseph S. Bednash
Part IV: Traditional Chinese Medicine in Lung Diseases
Chapter 13 Pulmonary Diseases and Traditional Chinese Medicine
Baochang Zhao, Xiaohong Shu, and Hong Zhang
Biography
Yutong Zhao is a Professor of Physiology and Cell Biology at The Ohio State University. He received his clinical medical degree from Dalian Medical University in China and PhD degree from Gifu University School of Medicine in Japan. He was trained in biochemistry, molecular biology, and active lipid signaling during his PhD student period. He joined a pulmonary postdoctoral training program at Johns Hopkins University School of Medicine and received his first NIH R01 funding at the University of Chicago as a Research Assistant Professor. Dr. Zhao is an expert in research fields of lung biology, bioactive lysophospholipid, and protein ubiquitination. His research focuses on investigating the pathogenesis of lung diseases including acute respiratory distress syndrome, pulmonary fibrosis, pulmonary arterial hypertension, asthma, lung cancer, and COPD. The goal of Dr. Zhao’s laboratory research is to develop new therapeutic targets for treating lung diseases. Dr. Zhao is active in academic professional services as a reviewer, associate editor, and member of editorial boards of scientific journals and grant review study sections.
