1st Edition

Lung Biology and Pathophysiology

Edited By Yutong Zhao Copyright 2024
290 Pages 28 Color & 23 B/W Illustrations
by CRC Press

290 Pages 28 Color & 23 B/W Illustrations
by CRC Press

The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and... Read more

Editor Biography 

List of Contributors 

Preface 

                Yutong Zhao

Acknowledgement

Part I: Lung Health and Pulmonary Diseases

Chapter 1             Antimicrobial Peptides in Lung Health and Pulmonary Diseases 

                                Jenna M. Kuhn and Yuanpu Peter Di

Chapter 2             Alveolar Epithelium in Lung Injury and Repair 

                                SeungHye Han

Chapter 3             Environmental Toxicants in Lung Diseases 

                Samuel J. Cochran, Evangeline Schott, Brett Saunders, and Kymberly M. Gowdy

Chapter 4             Epigenetic Modifications of Histone in Lung Fibrosis

                                Yan Y. Sanders

Chapter 5             Translational Potential of Hypoxia-inducible factor-2α Signaling in Pulmonary Hypertension 

                Zhiyu Dai

Part II: Research Strategies and Methods in Lung Biology and Pathophysiology

Chapter 6             Utility of Lung Organoids to Accelerate Our Understanding of Human Pulmonary Development and Diseases 

                                Nicole Pek and Mingxia Gu

Chapter 7             Establishment of Animal Models of Pulmonary Fibrosis 

                                Maolin Yao, Mo Chen, and Lian Li

Chapter 8             Research Strategies for Investigating Protein Ubiquitination in Lung Diseases 

                                Yutong Zhao

Chapter 9             Peroxidative Metabolism of Lung Lipids in Pulmonary Health and Disease: Emphasis on Methods of Analysis of Oxidative Modification of Polyunsaturated Membrane Phospholipids 

Austin C. Elliott, Lasya Kopuri, Surya Narla, Patrick J. Oliver, Anita Yenigalla, Elliott D. Crouser, Krishna Rao Maddipati, Thomas J. Hund, Narasimham L. Parinandi

Part III: Pathogenesis and Therapies of COVID-19

Chapter 10          Renin-Angiotensin System (RAS) and COVID-19: Exploring the Impact, Inhibition, and Treatment Strategies 

                Qing Lin and Hongpeng Jia

Chapter 11          COVID-19 Therapeutics: Challenges and Opportunities 

                                Travis B. Lear, Bill B. Chen, and Yuan Liu

Chapter 12          Clinical manifestations and pathogenesis of COVID-19 pulmonary disease

                                Moemen Eltobgy, Finny Johns, and Joseph S. Bednash

Part IV: Traditional Chinese Medicine in Lung Diseases

Chapter 13          Pulmonary Diseases and Traditional Chinese Medicine

                                Baochang Zhao, Xiaohong Shu, and Hong Zhang

Biography

Yutong Zhao is a Professor of Physiology and Cell Biology at The Ohio State University. He received his clinical medical degree from Dalian Medical University in China and PhD degree from Gifu University School of Medicine in Japan. He was trained in biochemistry, molecular biology, and active lipid signaling during his PhD student period. He joined a pulmonary postdoctoral training program at Johns Hopkins University School of Medicine and received his first NIH R01 funding at the University of Chicago as a Research Assistant Professor. Dr. Zhao is an expert in research fields of lung biology, bioactive lysophospholipid, and protein ubiquitination. His research focuses on investigating the pathogenesis of lung diseases including acute respiratory distress syndrome, pulmonary fibrosis, pulmonary arterial hypertension, asthma, lung cancer, and COPD. The goal of Dr. Zhao’s laboratory research is to develop new therapeutic targets for treating lung diseases. Dr. Zhao is active in academic professional services as a reviewer, associate editor, and member of editorial boards of scientific journals and grant review study sections.