Signal Transduction in the Retina: 1st Edition (Hardback) book cover

Signal Transduction in the Retina

1st Edition

Edited by Steven J. Fliesler, Oleg G. Kisselev

CRC Press

408 pages | 4 Color Illus. | 101 B/W Illus.

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Hardback: 9780849373152
pub: 2007-12-26
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In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approaches that yield key information on the mechanisms underlying normal retinal physiology. This in-depth work discusses the latest techniques and applications for understanding retinal function and degradation, developing novel therapeutic strategies, and promoting cellular survival and functional retention.

Drawing contributions from experts in a range of disciplines, each chapter presents a brief overview of the area discussed along with specific methodology for obtaining the primary data to understand the cellular and molecular process. Given the dominance and wealth of information on rhodopsin-based phototransduction, the book devotes substantial attention to this topic, but also evaluates a diversity of signaling mechanisms.

Beginning with the molecular mechanisms of vertebrate phototransduction, this volume presents the structure of phototransduction cascade components at atomic resolution, as well as molecular interactions in multi-protein complexes and novel cell-based strategies for understanding signal shut-off and light adaptation. It discusses non-visual phototransduction and the role of melanopsin in adaptive photoresponses and circadian clock regulation. The book also compares the visual signaling processes of vertebrates and invertebrates. It examines experimental studies of insulin-based signaling in the inner and outer retina; investigates retinal development including signaling in progenitor cells, cell-cell communication in developing cells, and neovascularization; and studies lipid-derived mediators such as neuroprotectins and discusses the participation of retinal pigment epithelium in neuronal survival.

Table of Contents

Vertebrate Visual Phototransduction

Biophysical Approaches to the Study of G-protein Structure and Function, A.M. Preininger, W.M. Oldham, and H.E. Hamm

Photoactivation of Rhodopsin and Signal Transfer to Transducin, O.G. Kisselev

How Rod Arrestin Achieved Perfection: Regulation of its Availability and Binding Selectivity, V.V. Gurevich, S.M. Hanson, E.V. Gurevich, and S.A. Vishnivetskiy           

Function and Regulation of PDE6, M. Natochin, H. Muradov, and N.O. Artemyev

Biochemical Characterization of Phototransduction RGS9-1 GAP Complex, Q. Wang and T.G. Wensel

Guanylate Cyclase-Based Signaling in Photoreceptors and Retina, K.W. Koch and A. Helten

Transgenic Strategies for Analysis of Photoreceptor Function, J. Lem and K. Rwayitare

Vertebrate Non-Visual Phototransduction

Melanopsin Signaling and Non-Visual Ocular Photoreception, S.V. Yelamanchili, V. Piamonte, S. Kumar Nayak, N. Tanaka, Q. Zhu, K. Jones, H.Le, and S. Panda

Invertebrate Visual Phototransduction

Phototransduction in Drosophila: Use of Microarrays in Cloning Genes Identified by Chemically Induced Mutations causing ERG Defects, H.T. Leung, L. An, J. Tseng-Crank, E. Kim, E.L. Harness, Y. Zhou, J. Kitamoto, G. Li, R.W. Doerge, and W.L. Pak

Insulin Receptor-Based Signaling in the Vertebrate Retina

Insulin Receptor-Based Signaling in the Retina, P.E. Fort, R.S.J. Singh, M.K. Losiewicz, and T.W. Gardner

Probing the Interactions between the Retinal Insulin Receptor and its Downstream Effectors, R.V.S. Rajala and R.E. Anderson

Signal Transduction in Vertebrate Retinal Development and Vascular Homeostasis

Signal Transduction in Retinal Progenitor Cells, B. Nelson, S. Hayes, B. Hartman, and T. Reh

Probing the Hedgehog Pathway in Retinal Development, B. McNeill, D. Wall, S. Beug and V.A. Wallace

Thrombospondin-1 Signal Transduction and Retinal Vascular Homeostasis, N. Sheibani, Y. Tang, T. DiMaio, S. Kondo, E.A. Scheef, and C.M. Sorenson

Lipid Mediators and Signaling in the RPE

Lipidomic Approaches to Neuroprotection Signaling in the Retinal Pigment Epithelium, N.G. Bazan, V.L. Marcheselli, Y. Lu, S. Hong, and F. Jackson

About the Series

Methods in Signal Transduction Series

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Surgery / General
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / General
SCIENCE / Life Sciences / Neuroscience