1st Edition
Nonclassical Ion Channels in the Nervous System
Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.
Preface
Editors
Contributors
1. Endogenous Activation and Neurophysiological Functions of Acid-Sensing Ion Channels
Wei-Zheng Zeng, Yi-Zhi Wang, and Tian-Le Xu
2. Acid-Sensing Ion Channels and Synaptic Plasticity: A Revisit
Ming-Gang Liu, Michael X. Zhu, and Tian-Le Xu
3. Trimeric Scaffold Ligand-Gated Ion Channels
Xiao-Na Yang, Si-Yu Wang, Jin Wang, and Ye Yu
4. Eukaryotic Mechanosensitive Ion Channels
Wei-Zheng Zeng and Bailong Xiao
5. Ion Channels in Human Pluripotent Stem Cells and Their Neural Derivatives
Ritika Raghavan, Robert Juniewicz, Maharaib Syed, Michael Lin, and Peng Jiang
6. Exocytosis of Nonclassical Neurotransmitters
Xiao Su, Vincent R. Mirabella, Kenneth G. Paradiso, and Zhiping P. Pang
7. Nonclassical Ion Channels in Learning and Memory
Ze-Jie Lin, Xue Gu, Tian-Le Xu, and Wei-Guang Li
8. Neuropeptide Regulation of Ion Channels and Food Intake
Xiaobing Zhang
9. Prefrontal Inhibitory Signaling in the Control of Social Behaviors
Qian Yang, Jun Wang, and Han Xu
10. Studying Brain Function Using Non-human Primate Models
Neng Gong
11. Application of In Vivo Ca2+ Imaging in the Pathological Study of Autism Spectrum Disorders
Pan Xu, Yuanlei Yue, and Hui Lu
12. Nonclassical Ion Channels in Depression
Zahra Farzinpour and Zhi Zhang
13. Ion Channels of Reward Pathway in Drug Abuse
Wen Zhang
14. Ion Channel Conformational Coupling in Ischemic Neuronal Death
Yi-Zhi Wang and Michael X. Zhu
15. Nonclassical Ion Channels and Ischemia
Jun Gao and Hui-Xin Zhang
16. Transient Receptor Potential Channels and Itch
Mahar Fatima, Jingyi Liu, and Bo Duan
17. Two-Pore Domain Potassium Channels in Pain and Depression
Shaoying Zhang and Huaiyu Yang
18. Lysosomal Ion Channels and Human Diseases
Peng Huang, Mengnan Xu, Yi Wu, and Xian-Ping Dong
19. Microglial Voltage-Gated Proton Channel Hv1 in Neurological Disorders
Madhuvika Murugan and Long-Jun Wu
Index
Biography
Tian-Le Xu, PhD, Principal Investigator and Professor
Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai
Dr. Tian-Le Xu obtained PhD of Neurobiology from Fourth Military Medical University. He did his postdoc training at Kyushu University and then joined University of Science and Technology of China as Professor. He was a principal investigator at Institute of Neuroscience, Chinese Academy of Sciences. Currently, he is Professor at Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine. Dr. Xu’s research focuses on neuronal signaling and related neural disorders including chronic pain and ischemic stroke, with an emphasis on the role of acid-sensing ion channels (ASICs) in these processes. The research from Dr. Xu’s lab has unveiled rich and new knowledge on the regulation and diverse functions of ASICs in health and disease.
Long-Jun Wu, PhD, Professor and Consultant
Department of Neurology, Mayo Clinic
Dr. Long-Jun Wu received PhD of Neurobiology from University of Science and Technology of China. After postdoc trainings at University of Toronto and Harvard Medical School, Dr. Wu was Instructor at Harvard Medical School and then Assistant Professor at Rutgers University. Currently, he is Professor and Consultant at Department of Neurology, Mayo Clinic. Dr. Wu’s recent research primarily focuses on the neuroimmune interaction, particularly the function of microglial ion channels and receptors, in normal and diseased brain. By understanding and manipulating microglial functions, Dr. Wu’s research aim to develop potential therapeutics targeting microglia in the treatment of various neurological disorders, such as epilepsy, chronic pain, stroke, neurodegeneration and autoimmune neurology.
