Signaling Through Cell Adhesion Molecules: 1st Edition (Hardback) book cover

Signaling Through Cell Adhesion Molecules

1st Edition

By Jun-Lin Guan

CRC Press

392 pages

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Hardback: 9780849333859
pub: 1999-05-20
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The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and malignant transformation. However, it is only recently realized that cell adhesion molecules are capable of transduce biochemical signals across the plasma membrane to regulate cellular functions.

Signaling Through Cell Adhesion Molecules brings together novel and current methodology employed in studies of signaling by cell adhesion molecules as presented by leading experts whose research has shaped this nascent area of signal trandsduction research.

One of the unique features of this method book is its topic-oriented format; experts with "hands-on" experience present various techniques and answers to particular biological questions. Many chapters not only contain the "recipes" on experimental protocols, but also discuss the rationale behind their development.

Table of Contents

Protein-Protein Interactions and Early Events in Integrin Signaling

The Use of Chimeric Receptors in the Study of Integrin Signaling

Using Synthetic Peptides to Mimic Integrins: Probing Cytoskeletal Interactions and Signaling Pathways

Use of the Yeast Two-Hybrid System for the Characterization of Integrin

Signal Transduction Pathways: Identification of the Integrin-Linked Kinase, p59

Focal Adhesion Kinase and its Associated Proteins

Analysis of Paxillin as a Multi-Domain Scaffolding Protein

p130 in Integrin Signaling

Specificity of Integrin Signaling

Late Events and Biological Functions of Integrin Signaling

Methods for Study of Integrin Regulation of MAP Kinase Cascades

Methods for Analysis of Adhesion-Dependent Cell Cycle Progression

Integrin Modulation of Mitogenic Pathways Involved in Muscle Differentiation

Methods for Studying Anoikis

Functional Analysis of FAK and Associated Molecules in Cell Migration

Integrin Signaling in Pericellular Matrix Assembly

Inside-out Signaling by Integrins

Studies of Integrin Signaling Through Platelet ab

Tracking of Integrin-Mediated Adhesion Using Green Fluorescent Protein and Flow Cytometry

Expression Cloning of Proteins That Modify Integrin Activation

Regulation of Cell Contractility by RhoA: Stress Fiber and Focal Adhesion Assembly

Studies of Integrin Signaling Through Platelet General Methods for Studies of Cell Adhesion Molecule-Mediated Signaling

Intra-and Intercellular Localization of Proteins in Tissue in situ

Optical Microscopy Studies of (Ca2) Signaling

Wnt Signaling in Xenopus Embryos

About the Series

Methods in Signal Transduction Series

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / Neuroscience