1st Edition

Angiotensin II Receptors



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ISBN 9780849385452
Published September 6, 1994 by CRC Press
240 Pages

USD $385.00

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Book Description

This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors.
This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.

Table of Contents

Introduction: Medicinal Chemistry of Angiotensin II Receptors, J. Gleason and R.R. Ruffolo, Jr.
Structure-Activity Relationships of Peptide Angiotensin II Receptor Agonists and Antagonists, J. Samanen and D. Regoli
Conformational Models of Angiotensin II for Nonpeptide Antagonist Design, J. Samanen, J. Hempel, R. Keenan, C. Peishoff, and J. Weinstock
Structure Activity Relationships of Nonpeptide Angiotensin II Receptor Antagonists, J. Weinstock and R.M. Keenan
Index

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