386 pages | 17 Color Illus. | 29 B/W Illus.
Aptamers, often termed as ‘chemical antibodies,’ are an emerging class of synthetic ligands for efficient target-specific molecular recognition. The objective of this book is to highlight recent advances and potential of aptamers in various disease conditions. . This book focuses on the applications of aptamers in targeted nanotherapy, detection, and in molecular imaging in various disease conditions such as cancer, neurological diseases and infectious diseases.
Aptamers-General Introduction. History of aptamer development. Peptide aptamers: Development and applications. Aptamer selection methodologies. Selection and application of catalytically active oligonucleotides. Aptamer Development for Therapeutic Applications. Stem-cell specific aptamers for targeted cancer therapy. Aptamers as therapeutic tools in neurological diseases. Aptamers in bacterial, viral and parasitic diseases. Aptamers for Targeted Drug Delivery & Nanotherapy. Aptamers as tools for targeted drug delivery. Aptamer-liposome conjugates: Current art and future prospects. Application of Aptamers as Biosensors. Aptamers in medical diagnosis. Aptamers for Target Specific Imaging. Molecular imaging utilizing aptamer-targeted probes. Clinical Utility Scope and Limitations of Aptamers. First therapeutic aptamer: VEGF-targeting Macugen. Aptamers: Scope, limitations and future prospects.