Drug Delivery Across Physiological Barriers: 1st Edition (Hardback) book cover

Drug Delivery Across Physiological Barriers

1st Edition

Edited by Silvia Muro

Pan Stanford

426 pages | 51 B/W Illus.

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Hardback: 9789814669405
pub: 2016-04-06
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Description

Transport of pharmaceutical agents in the body is paramount to therapeutic efficacy. Advances in the past decades have rendered a remarkable improvement of drug delivery strategies, which has helped to increase the bioavailability of therapeutic agents by protecting them from degradation, targeting them to diseased sites, and controlling their circulation time and release rate. Additionally, for most therapeutics, reaching the targets of action require penetration across tissues and/or entry within cells. The design of strategies to control the transport of therapeutic compounds through these physiological barriers has become an imperative and a challenging need in the quest for better therapeutics. This book provides an overview of the current advances in this field, including considerations on the biological regulation and natural mechanisms overcoming these barriers, as well as drug delivery strategies facilitating the transport of drugs and their carriers at the tissue, cell, and subcellular levels.

Reviews

"This book combines a thorough overview of the barriers encountered and strategies employed to increase the delivery of therapeutics. It also provides a critical assessment of the merits and limitations of delivery approaches. Overall, this is a concentrate of the most recent scientific discoveries written by highly recognized authors in the field. It is an excellent reference for both students and seasoned scientists."

—Dr. Mohamed ElSayed, University of Michigan, USA

"Drug delivery across physiological barriers is a historic and challenging problem. This compelling book addresses this topic thoroughly, with detailed chapters ranging from descriptions of the composition of physiological barriers, through barrier-penetrating drug delivery strategies to how drugs are trafficked once inside cells. A must-have addition to any pharmaceutical scientist’s technical library."

—Dr. John D. Higgins, Merck & Co., USA

"Drug Delivery Across Physiological Barriers is a fundamental book in nanomedicine, particularly for those who start in the field of designing therapeutic strategies based on nano-drug delivery systems. It addresses the challenging anatomical and pathological barriers of the epithelia, endothelia, extracellular matrix, and cell endocytic pathways. It shows that a thorough understanding of the stepwise processing to which nanostructures are exposed throughout the body and intracellularly is a critical tool for a wise design of nanomedicines."

—Dr. Eder L. Romero, National University of Quilmes, Argentina

Table of Contents

Introduction

Physiological Barriers Controlling Penetration and Transport of Substances in the Body

Structure and function of epithelial and endothelial barriers, Michael Koval

The plasma membrane as a semipermeable barrier, Guido Li Volsi

Biology and regulation of protein sorting and vesicular transport, Ian Mather

Pathogens and intracellular transport, Lali Medina-Kauwe

Strategies for Drug Penetration across Tissue Compartments

Drug transport across the skin, Renata Vidor Contri, Tatiele Katzer, Silvia S. Guterres, Adriana R. Pohlmann

Mucosal barriers, Michelle Dawson, Deepraj Ghosh

Transport of therapeutics across the gastrointestinal epithelium, Frederic Lagarce, Roger Emilie

Crossing the endothelial barrier, Bhawani Aryasomayajula, Shravan Kumar Sriraman, Vladimir P. Torchilin

Nanoparticle-based drug delivery to solid tumors, Sara A. Abouelmagd, Yoon Yeo

Drug Transport into Cells and Subsequent Intracellular Trafficking

Membrane lipids and drug transport, Vinod Labhasetwar

Drug delivery systems that fuse with the plasmalemma, Muriel Blanzat, Marie-Pierre Rols, Justin Teissié

Endocytosis and the endolysosomal route in drug delivery, Jeff Rappaport, Iason Papademetriou, Silvia Muro

Endo-lysosomal escape, Manju Saraswathy, David Oupicky

Intracellular transport to the mitochondria and other organelles, Gerard G. M. D’Souza, Paul H. Nguyen, Volkmar Weissig

About the Editor

Silvia Muro is an associate professor in the Institute for Bioscience and Biotechnology Research and the Department of Bioengineering, University of Maryland, USA. She obtained her PhD in sciences (molecular biology) from Universidad Autónoma de Madrid, Spain. She received a postdoctoral training in drug delivery and obtained a research assistant professor position in the Pharmacology Department at the University of Pennsylvania, USA. Her research focuses on targeting and transport of nanomedicines into and across cells, with emphasis on delivery of biological therapeutics for treatment of inherited enzyme deficiencies. Her work has received awards from the Controlled Release Society, the American Society for Nanomedicine, and others, and since 2012 she is a standing member of the Nanotechnology Study Section [NANO] of the USA National Institute of Health.

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
MED072000
MEDICAL / Pharmacy
TEC021000
TECHNOLOGY & ENGINEERING / Material Science