Bioactive Peptides: Applications for Improving Nutrition and Health, 1st Edition (Hardback) book cover

Bioactive Peptides

Applications for Improving Nutrition and Health, 1st Edition

By Richard Owusu-Apenten

CRC Press

414 pages | 62 B/W Illus.

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Hardback: 9781439813621
pub: 2010-06-23
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Chronic illnesses, injury, or infections produce a decline in muscle mass―leading to delayed recovery, more post-treatment complications, longer hospital stays, and higher mortality rates. Therefore, ensuring adequate lean body mass is of major concern in health care. Presenting data from human studies and trials, along with recent research findings, Bioactive Peptides: Applications for Improving Nutrition and Health summarizes the applications, and benefits of bioactive peptides used to mitigate major metabolic derangements that arise from chronic illnesses and result in unwanted weight loss.

Reviews the Latest Theories Explaining Muscle Loss and Accretion

During Illness & Infection

In chapters one through five, the book presents the background science on the relationship between illness and muscle weight loss, highlighting bioactive peptides’ ability to enhance the body’s antioxidant status, antisepsis capacity, immune function, anti-inflammatory capacity, growth potential, and appetite. Chapters six through nine deal with the use of bioactive peptides to modify aspects of the host response to illness, including inflammation, antimicrobial activity, anabolic dysfunction, and anorexia.

This state-of-the-art reference also includes case studies on aging, AIDS, COPD, diabetes, inflammatory bowel disease, kidney failure, and tuberculosis. It is a valuable resource for dieticians, doctors, nutritionists, and manufacturers of medical foods, tube feeds, supplements, and nutraceuticals.

Table of Contents

Nutrition and the Host Response to Infection and Injury

Nutrition and Illness

Host Response to Injury

Unintended Weight Loss

Multimodal Nutritional Support Using Bioactive Peptides

Summary and Conclusions


Bioactive Peptides for Nutrition and Health


Bioactive Peptides and Proteins

Applications of Protein Supplements for Health

Perspectives on Human Trial Data

Summary and Conclusions



Dietary Protein Requirements for Health


Dietary Protein Quality Relation to Health

Protein Requirements and Health

Dietary Protein and Host Responses to Illness

Peptides and Protein Bioactivity

Types of Dietary Protein Health Effects

Summary and Conclusion



Protein Turnover and Economics within the Body

Protein Turnover and Wasting

Baseline Whole Body Protein Turnover

Regional Protein Turnover

Nutrients and Protein Turnover

Slow and Fast Proteins

Summary and Conclusions


Major Processes for Muscle Gain and Loss



Muscle Cell Death and Atrophy

Proteolysis via Ubiquitin Proteasome

Further Signaling Pathways for Muscle Atrophy

Mammalian Target of Rapamycin and Hypertrophy

Summary and Conclusions

Appendix 5.A.1 Details of mTOR Signaling


Inflammation and Innate Immune Response

Types of Inflammation

Proinflammatory Signaling

Anti-Inflammatory Bioactive Peptides and Supplements

In Vivo Applications and Controlled Trials

Summary and Conclusions


Infection and Sepsis


Pathogen Recognition and Intracellular Signaling

Host Antimicrobial Peptides

Functions of Antimicrobial Peptides

In Vivo Applications and Human-Trials of AMPs

Summary and Conclusions


Anabolic Dysfunction


Insulin and Muscle Protein Metabolism

Growth Hormone and IGF-1

Growth Hormone Secretagogues

Leucine, BCAA, and Related Peptides

In Vivo Applications and Clinical Trials


Bioactive Peptides for Alleviating Illness Anorexia

Illness Anorexia

Leptin and Food Intake

Melanocortin Peptides


Other Bioactive Peptides for Moderating Appetite

In Vivo Studies and Controlled Trials

Summary and Conclusions


About the Author

Richard Owusu-Apenten is a faculty member at the Northern Ireland Centre for Food and Health (NICHE), School of Biomedical Science, University of Ulster, Coleraine.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Nutrition