Biological Effects of Low Level Exposures Dose-Response Relationships: 1st Edition (Hardback) book cover

Biological Effects of Low Level Exposures Dose-Response Relationships

1st Edition

By Edward J. Calabrese

CRC Press

320 pages

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Hardback: 9781566700931
pub: 1994-05-19

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Biological Effects of Low-Level Exposures, more commonly referred to as BELLE, began as a conference in May 1990. Its members are committed to the enhanced understanding of low-dose responses of all types to human exposures to chemical and physical agents, whether of an expected or paradoxical nature.

The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in both in vitro systems and in vivo systems, including human populations. While BELLE promotes the scientific understanding of low-level effects, its primary goal is the scientific evaluation of existing literature and ways to improve research and assessment methods.

Table of Contents

Historical, Philosophical, Conceptual Foundations of BELLE Research

Changing Scientific Paradigms, K.F. Schaffner

A Brief History and Critique of the Low Dose Effects Paradigm, L. Sagan

Primer on BELLE, E.J. Calabrese

Commentary on Changing Paradigms: Consistencies and Inconsistencies of Changes in Molecular to Biological Events During Malignant Progression in Transformed Human Cells, G.E. Milo

Biological Effects of Low Level Exposure to Chemicals

Nonmonotonic Dose-Response Relationships in Toxicological Studies, J.M. Davis and D.J. Svendsgaard

Biostatistical Approaches to Low Level Exposures, D.W. Gaylor

Responses in Humans to Low Level Exposures, R.R. Cook

Cellular and Molecular Foundations of Hormetic Mechanisms, H.M. Mehendale

Modulation of Toxicity by Diet: Implications for Response at Low Level Exposures, A. Turutrro and R. Hart

Biological Effects of Low Level Exposure to Radiation

What Can be Learned from Epidemiologic Studies of Persons Exposed to Low Doses of Radiation? E.S. Gilbert

Positive Health Effects of Low Level Radiation in Human Populations, M. Pollycove

Test of the Linear-No Threshold Theory of Radiation Carcinogenesis, B.L. Cohen

Bayesian Estimation of Incidence Change-Points in Low Dose Experimental and Epidemiologic Studies, B.A. Carnes

Radiation-Induced Carcinogenesis: Paradigm Considerations, J.E. Trosko

Stress Proteins and Radiation, J. Smith-Sonneborn

Adaptive Responses After Exposure to Low Dose Radiation, C.K. Hill and T. Godfrey

BELLE Conference Perspectives and Summary

Synopsis of the BELLE Conference on Chemicals and Radiation, J.D. Graham

New Perspectives on Dose-Response Relationships and Low Level Exposures, J. Higginson

BELLE Conference: A Summary, L. Sagan

Appendix: What is BELLE? Where is BELLE and Who Sponsors It?

List of Acronyms and Abbreviations

List of Contributors


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
SCIENCE / Chemistry / General