Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids: 1st Edition (Hardback) book cover

Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids

1st Edition

Edited by Ram I. Mahato

CRC Press

712 pages | 4 Color Illus. | 220 B/W Illus.

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pub: 2004-12-28
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Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases.

Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids.

Combining an introduction to biomaterial delivery with the latest developments in the field, this is a valuable reference for both the novice student and the practicing scientist on delivery of biomaterials, on biomedical polymers, and on polymer therapeutics. Understanding these core fundamentals is critical to moving on to more advanced study.


"…provides an excellent introduction to the use of biomaterials in the delivery and targeting of proteins, nucleic acids, genes, and other large molecules….excellent…remarkably integrated…rationally organized."

J. Howard Rytting, Ph.D., University of Kansas Medical Center

Table of Contents

Structures, Properties, and Characterization of Biomaterials, A. Nan and H. Ghandehari

Step-Reaction and Ring-Opening Polymerization, R.P. Pawar and A.J. Domb

Copolymer, Block Copolymers Stimuli-Sensitive Polymers, K.M. Huh, S.C. Lee, Y.J. and K. Park

Polymer Solution Properties, Polymer Networks, Micelles, Dendrimers, Hydrogels, T. Ooya and K. Park

Protein Conjugation, Cross-linking and PEGylation, K.D. Hinds

Complement Activation by Injectable Polymeric Carriers, C. Passirani and J-P. Benoit

Biological Membranes and Barriers, Y. Omidi and M. Gumbleton

Pharmacokinetics of Proteins and Nucleic Acid Drugs, B. Meibohm

In Vivo Fate of Polymeric GENE Carriers, D. Fischer

Subcellular Fate of sProteins and Nucleic Acids, D. Oupicky

Stability of Proteins and Nucleic Acids, Z-R. Lu

Formulation, Stability and Characterization of Protein and Peptide Drugs, S. Frokjaer

Micro- and Nanoparticulate Polymeric Delivery Systems for Nucleic Acid-based Medicines, S.P. Barman and M.L. Hedley

Liposomal Delivery Systems of Proteins and Peptide Drugs, V. Torchillin

Mechanisms of Cellular Drug Resistance and Strategies to Overcome It, T. Minko

Transporters as Molecular Targets for Drug Delivery and Disposition, I. Tamai

Protein Transduction Domains as a Novel Tool for Delivery of Protein, Peptides and Nucleic Acids, R.L. Pastori, M.M. Ribeiro, D. Klein, and C. Ricordi

Introduction to Therapeutic Nucleic Acids, A. G. Schätzlein

Antisense and Antigene Oligonucleotide Delivery, R.I. Mahato, Z. Ye, and R.V. Guntaka

Artificial Nucleic Acid Chaperones, A. Maruyama

Basic Components of Plasmid-Based Gene Expression Systems, M. Lee and S.W. Kim

Design Elements of Polymeric Gene Carriers, J.S. Choi and J.-S. Park

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
SCIENCE / Life Sciences / General