This book explores central aspects of genetic modification of animals for scientific purposes in the context technological possibilities, regulatory issues in different regions, animal welfare implications and wider ethical issues exemplified through current theories and frameworks.
This discussion of lab animals produced through modern biotechnologies becomes increasingly pressing as CRISPR-Cas9 technology advances rapidly, challenging legal and ethical frameworks all over the world. Such animals are now affordable and readily available to almost every branch of scientific research. This not only raises enormous potential for creating ‘tailored’ models for human diseases but also rubs up against the traditional guiding principles (the 3Rs) for the humane use of animals for scientific experiments and raises wider ethical issues around death, integrity and naturalness. In this book, expert authors from diverse backgrounds in laboratory animal care, animal research, technology and animal rights explore a range of topics, from the science behind biotech research animals and the regulation of their use, to utilitarian, animal rights, virtue ethics and ethics of care, and critical animal studiers' perspectives on the use of these technologies.
Whatever your background or role in animal research, this book will challenge and stimulate deeper consideration of the benefits, disadvantages and ethical consequences of the use of biotechnology in the animal laboratory.
Chapter 1: Introduction
Mickey Gjerris, Anna Kornum, Helena Röcklinsberg and Dorte Bratbo Sørensen
Chapter 2: The Science Behind GM Research Animals
Elisabeth Jonas, Anna Kornum, Mickey Gjerris, Helena Röcklinsberg and Dorte Bratbo Sørensen
Chapter 3: An Overview of the Regulation of Genetically Altered Animals in Research
Larisa Rudenko, Laura M. Plunkett, Anna Kornum, Helena Röcklinsberg, Dorte Bratbo Sørensen and Mickey Gjerris
Chapter 4: Welfare and 3Rs
Anna Kornum, Helena Röcklinsberg, Mickey Gjerris and Dorte Bratbo Sørensen
Chapter 5: Beyond Welfare
Mickey Gjerris, James Yeates, Anna Kornum, Dorte Bratbo Sørensen and Helena Röcklinsberg
Chapter 6: A Utilitarian Perspective on Animal Experimentation Involving Genetic Modification by Tatjana Višak
Chapter 7: Animal Rights View
Chapter 8: The Virtues and Vices of Germline Editing Research
Chapter 9: An Ethic of Care Critique of Induced Genetic Mutation in Animals
Chapter 10: The Privileged Ones
Chapter 11: The Ethical Assessment Process
Helena Röcklinsberg, Dorte Bratbo Sørensen, Anna Kornum and Mickey Gjerris