1st Edition
Cell Adhesion and Communication Mediated by the CEA Family
By Clifford P Stanners
Copyright 1998
324 Pages
by
CRC Press
324 Pages
by
CRC Press
Also available as eBook on:
Considers the recent explosion of knowledge about the carcinoembryonic antigen (CEA) family, which resulted from the molecular cloning of family member genes in 1986. Results indicating CEA family members upregulated in cancer could have an instrumental role in malignant transformation and metastasis, while those that are downregulated could have tumor suppressive functions are considered.... Read more
1. The Nature and Expression of the Human CEA Family 2. Cell Adhesion and Signalling by the Rodent CEA Family 3. Signal Transduction Mediated by the CEA Family 4. Role of C-CAM as a Tumor Suppressor 5. CEA and Metastasis: A Facilitator of Site-Specific Metastasis 6. The CEA Gene Promoter as a Driver of Tumor-Specific Gene Expression for Gene Therapy 7. Novel Clinical Applications of CEA in Cancer Imaging and Therapy with Radiolabelled Antibodies 8. Mice Transgenic for the CEA Gene as a Model for Cancer Immunotherapy and Antibody Targeting Studies
Biography
Clifford P Stanners
