Considers the recent explosion of knowledge about the carcinoembryonic antigen (CEA) family, which resulted from the molecular cloning of family member genes in 1986.
Results indicating CEA family members upregulated in cancer could have an instrumental role in malignant transformation and metastasis, while those that are downregulated could have tumor suppressive functions are considered. Reviews, recent results, hypotheses, and clinical applications regarding a gene family that, from its widespread changes in expression in tumors at many sites, should be regarded as a "major player" in human cancer are also discussed. The normal functions such as epithelial and hematopoietic adhesion and signalling molecules are explored, and the possibly unique role of this family in evolution is introduced.
This volume will be of interest to researchers in the fields of intercellular adhesion, evolution, and molecular recognition, as well as clinicians interested in the recent knowledge regarding a tumor marker commonly utilised in the clinic, and companies wishing to exploit this cancer-related family for novel commercial applications in the biomedical sphere.
1. The Nature and Expression of the Human CEA Family 2. Cell Adhesion and Signalling by the Rodent CEA Family 3. Signal Transduction Mediated by the CEA Family 4. Role of C-CAM as a Tumor Suppressor 5. CEA and Metastasis: A Facilitator of Site-Specific Metastasis 6. The CEA Gene Promoter as a Driver of Tumor-Specific Gene Expression for Gene Therapy 7. Novel Clinical Applications of CEA in Cancer Imaging and Therapy with Radiolabelled Antibodies 8. Mice Transgenic for the CEA Gene as a Model for Cancer Immunotherapy and Antibody Targeting Studies