This unique book presents an approach to viewing trauma. It examines the cellular consequences of trauma at a molecular level and provides new insights into the treatment of traumatic injury, based on cellular responses. The current of trauma research is reviewed, previously unpublished information on the topic is presented, and research directions are included.

    Mechanisms of Lethal Cell Injury
    Models of Toxicity Screening Using Cultured Cells, R.L. Grant and D. Acosta, Jr.
    Apoptosis: Cellular Signaling and Molecular Mechanisms, R.B. Evans and J.A. Cidlowski
    Role of Mitochondrial Injury During Oxidative Injury to Hepatocytes: Evidence of a Mitochondrial Permeability Transition by Laser Scanning Confocal Microscopy, A.-L. Nieminen, R. Imberti, A.K. Saylor, S.A. Tesfai, B. Herman, and J.J. Lemasters
    Cytoprotective Strategies
    Glycine Cytoprotection and Inhibition of Nonlysosomal Calcium-Dependent Proteolysis During Anoxia Injury of Rat Hepatocytes, J.C. Nichols, R.C. Dickson, S.F. Bronk, and G.J. Gores
    Di-Calciphor-Dependent Protection against Cell Death Due to Mitochondrial Failure, D.P. Jones
    Role of Mitochondrial ATPase Inhibitor, IF1, in Cytoprotection During Ischemia in Slow and Fast Heart-Rate Hearts, W. Rouslin and C.W. Broge
    The Discovery and Pharmacology of Tirilazad Mesylate, J.M. McCall
    Ischemia/Reperfusion Injury
    The Role of Neutrophils and Reactive Oxygen Metabolites in Reperfusion Injury, B.J. Zimmerman and D.N. Granger
    The Inflammatory Response after Hepatic Ischemia-Reperfusion, H. Jaeschke
    The pH Paradox in Reperfusion Injury to Heart Cells, J.J. Lemasters, J.M. Bond, I.S. Harper, E. Chacon. H. Ohata, B. Herman, and W.E. Cascio
    Pathophysiology of Spinal Cord Injury in a Rat Model of Decompression Sickness, L. Marzella
    Stress Response and Wound Healing
    The Stress Response and Stress Proteins, M.E. Feder, D.A. Parsell, and S.L. Lindquist
    Cross Talk between Heat Shock and Oxidative Stress Inducible Genes During Myocardial Adaptation to Ischemia, D.K. Das and N. Maulik
    Alterations in Cell Cycle Control Factors and the Induction of Oxygen Regulated Proteins by Hypoxic Stress, H.C. Smith, R.L. Howell, and J.W. Ludlow
    Stress Proteins in Renal Ischemia, S. Hilden
    Human Keratinocyte Migration Involves Extracellular Matrix and Soluble Factors, D.T. Woodley, J.D. Chen, E. Shim, J.P. Kim, J.-C. Lapiere, and C. Peavey
    Endothelial Cell Signaling During Wound Healing, L.H. Romer
    Preservation of Cells and Organs
    Development and Optimization of Preservation Solutions, J.H. Southard
    Hypoxia, Free Radicals and Reperfusion Injury Following Cold Storage and Reperfusion of Livers for Transplantation, R.G. Thurman, W. Gao, H.D. Connor, S. Bachmann, R.T. Currin, R.P. Mason, and J.J. Lemasters
    Cellular Injury Associated with Organ Cryopreservation: Chemical Toxicity and Cooling Injury, G.M. Fahy, C. da Mouta, L. Tsonev. B.S. Khirabadi, P. Mehl, and H.T. Meryman


    John J. Lemasters, M.D., Ph.D., is Professor of Cell Biology and Anatomy and Member of the Curriculum in Toxicology at the University of North Carolina at Chapel Hill. Dr. Lemasters graduated in 1969 from Yale University, New Haven, Connecticut, with a B.A. degree in psychology (cum laude with honors) and obtained his M.D. degree and Ph.D. degree in anatomy and cell biology in 1975 from the Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr. Lemasters is a member of the American Association for the Advancement of Science, the American Association for the Study of Liver Diseases, the American Association of Anatomists, the American Heart Association, Council on Circulation, the American Physiological Society, the American Society for Biochemistry and Molecular Biology, the Biophysical Society, the American Society for Cell Biology, the Microscopy Society of America, and the Society of Toxicology. Dr. Lemasters serves on the editorial boards of the American Journal of Physiology: Cell Physiology, Cell Calcium, and Hepatology. He has been the recipient of many research grants from the National Institutes of Health, the National Science Foundation, the American Heart Association, and the Office of Naval Research. Dr. Lemasters is the author of over 200 papers and has previously edited two books. His current major research interests relate to ischemia/reperfusion injury and organ preservation for transplantation surgery. Constance Oliver, Ph.D., is a Program Officer in the Biomedical Science and Technology Program at the Office of Naval Research (ONR), Arlington, Virginia. Prior to joining ONR she was a Research Biologist at the National Institute of Dental Research, the National Institutes of Health, Bethesda, Maryland. She received her B A. degree from Northwestern University, Evanston, Illinois, her M.S. from the University of Utah, Salt Lake City, Utah, and her Ph.D. from the University of Texas at Austin, Austin, Texas. Dr. Oliver has over twenty years of experience in the field of cell biology. Her research has focused on structure-function relationships in the secretory pathway in exocrine acinar cells and in mast cells J She has examined packaging of secretory proteins and formation of secretory granules, membrane trafficking and signal transduction mechanisms in these cells. Currently, Dr. Oliver is managing research programs in Biomedical Science and Technology. She has published extensively and has made numerous presentations at local, national, and international conferences, workshops, and symposia based on her own research. In addition, she has edited several books and conference proceedings and served on the editorial board of The Journal of Histochemistry and Cytochemistry. Dr. Oliver is a member of the American Society for Cell Biology, the Histochemical Society, the Microscopy Society of America, the American Association for the Advancement of Science, the Association for Women in Science, and the Chesapeake Society of Electron Microscopy. In addition, she was elected to membership in Sigma Xi, an honorary academic society, named an Outstanding Young Woman of America, 1977, and received a Gold Medal from Tokyo Dental College, 1984.