Chemical Approaches to the Synthesis of Peptides and Proteins: 1st Edition (Hardback) book cover

Chemical Approaches to the Synthesis of Peptides and Proteins

1st Edition

By Paul Lloyd-Williams, Fernando Albericio, Ernest Giralt

CRC Press

304 pages

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Hardback: 9780849391422
pub: 1997-04-23
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Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications.

This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

Table of Contents


Amino Acids and Peptide and Protein Structure

Amino Acid Activation and Coupling

Protection Schemes for Peptide Synthesis

The Synthesis of Peptides

Solid-Phase Peptide Synthesis

The Solid Support

Protection Schemes

Attachment of the First Amino Acid to the Solid Support

Chain Elongation

Cleavage of the Peptide from the Resin

Examples of Protein Synthesis by Linear SPPS

Peptide Synthesis in Solution

Strategic Considerations

Protection Schemes

Chain Elongation

Final Removal of Protecting Groups

Special Approaches to the Synthesis of Peptides in Solution

Examples of Peptide Synthesis in Solution

Convergent Approaches to the Synthesis of Large Peptides and Proteins

Convergent Solid-Phase Peptide Synthesis

The Coupling of Protected Peptide Segments in Solution

Coupling of Minimally Protected Peptides in Aqueous Solution

Chemical Ligation of Peptide Segments

Formation of Disulfide Bridges

Peptides with Disulfide Bridges

Protection of Cysteine in Peptide Synthesis

Chemical Methods for the Formation of Disulfide Bridges

Regioselective Disulfide Bridge Formation

Peptide Libraries

Multiple Peptide Synthesis in Parallel

Peptide Library Techniques

Examples of Peptide Library Synthesisi

Each chapter contains References

About the Series

New Directions in Organic & Biological Chemistry

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
SCIENCE / Chemistry / Organic