1st Edition

Computational Biophysics of the Skin

Edited By Bernard Querleux Copyright 2015
    558 Pages 16 Color & 110 B/W Illustrations
    by Jenny Stanford Publishing

    The accessibility of the skin in vivo has resulted in the development of non-invasive methods in the past 40 years that offer accurate measurements of skin properties and structures from microscopic to macroscopic levels. However, the mechanisms involved in these properties are still only partly understood. Similar to many other domains, including biomedical engineering, numerical modeling has appeared as a complementary key actor for improving our knowledge of skin physiology.

    This book presents, for the first time, the contributions that focus on scientific computing and numerical modeling to offer a deeper understanding of the mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties and skin barrier function and homeostasis, with—for each of them—several chapters that describe either biological or physical models at different scales.

    Preface; Howard I. Maibach

    Foreword; Bernard Querleux

    PART 1: Skin color

    Multilayer Modeling of Skin Color and Translucency; Gladimir V. G. Baranoski, Tenn F. Chen, and Aravind Krishnaswamy

    Dermal component based optical modeling of the skin translucency: impact on the skin color; Igor Meglinski, Alexander Doronin, Alexey N. Bashkatov, Elina A. Genina, and Valery V. Tuchin

    Mathematics and biological process of skin pigmentation; Josef Thingnes, Leiv Øyehaug, and Eivind Hovig

    PART 2: Skin biomechanics

    State-of-the-art constitutive models of skin biomechanics; Georges Limbert

    Fiber-matrix models of the dermis; Cormac Flynn

    Cellular scale model of the stratum corneum; Roberto Santoprete, and Bernard Querleux

    PART 3: Skin barrier

    Mathematical models of skin permeability: microscopic transport models and their predictions; Gerald B. Kasting, and Johannes M. Nitsche

    Cellular scale modelling of the skin barrier; Dirk Feuchter, Michael Heisig, Arne Naegel, Martin Scherer, and Gabriel Wittum

    Molecular scale modeling of skin permeation; Sophie Martel, and Pierre-Alain Carrupt

    Accessing the molecular organization of the stratum corneum using high resolution electron microscopy and computer simulation; Lars Norlén, Jamshed Anwar, and Ozan Öktem

    PART 4: Skin fluids and components

    Water diffusion through stratum corneum; Robert E. Imhof, and Peng Xiao

    Accurate multi-scale skin model suitable for determining the sensitivity and specificity of changes of skin components; Jürg Fröhlich, Sonja Hulova, Christian Beyer, and Daniel Erni

    Model based Quantification of Skin Microcirculatory Perfusion; Ingemar Fredriksson, Marcus Larsson, and Tomas Strömberg

    PART 5: Skin homeostasis

    Graphical Multi-Scale Modeling of Epidermal Homeostasis with EPISIM; Thomas Sütterlin, and Niels Grabe

    Heuristic Modeling Applied to Epidermal Homeostasis; François Iris, Manuel Gea, Paul-Henri Lampe, and Bernard Querleux


    Bernard Querleux is senior research associate at the Worldwide Advanced Research center of L’Oreal Research & Innovation, France. He obtained his doctorate in electronic engineering and signal processing from the University of Grenoble, France, in 1987 and his habilitation in biophysics from Paris-Sud University, France, in 1995. Since 2005, Dr. Querleux is serving as scientific chairperson of the International Society for Biophysics and Imaging of the Skin. Apart from being an expert in functional brain imaging for the objective assessment of sensory perception, his main research interests concern the development of new non-invasive methods, including numerical modeling for skin and hair characterization.

    "This book presents an excellent overview of the state of the art in the computational modeling of the skin, ranging from optical and biomechanical modeling to a discussion on the skin barrier function and skin fluids. All chapters are written by internationally well-known researchers in the field, each of them supplying a comprehensive reference list for each chapter. It is an excellent read for anyone starting in the field and also a very good source of information for experts."

    Prof. Cees W. J. Oomens, Eindhoven University of Technology, The Netherlands


    "This book offers a fantastic approach to the non-invasive research of the skin. It will be a valuable reference for not only students but also experts in skin research."

    Prof. Chil Hwan Oh, Korea University, South Korea