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Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies book cover

1st Edition

Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies

By Diana Ivanova Stephanova, Bozhidar Dimitrov Kolev Copyright 2013
148 Pages 38 B/W Illustrations
by CRC Press

148 Pages
by CRC Press
Also available as eBook on:
This book covers the computer simulation of demyelinating neuropathies and neuronopathies and compares models with clinical findings. Through the approximation of nerve excitation and conduction, the authors show how the versatile structure of nerve fibers relates to different modes of focal prospects, inward and outward currents, conduction velocity, and errant transmission. They also explain how... Read more

Preface
Abbreviations
Nerve Fibres
Myelinated Axons
Demyelinating Neuropathies
Neuronopathies
Axonal Excitability
Mathematical Modeling of Nerve Fibres
Models and Methods for Investigation of the Human Motor Nerve Fibre
Multi–Layered and Double Cable Models
Line-Source Model
Methods of Stimulation and Calculation of the Potentials (Action, Electrotonic and Extracellular)
Methods for Calculation of the Strength-Duration Time
Constants, Rheobasic Currents and Recovery Cycles
Simulated Demyelinating Neuropathies and Neuronopathies
Simulation of CMT1A, CIDP, CIDP Subtypes, GBS, MMN and ALS
Abnormalities in the Potentials
Action Potentials
Electrotonic Potentials
Abnormalities in the Extracellular Potentials and their Mechanisms
Abnormalities in the Strength-Duration Time Constants Rheobasic Currents and their Mechanisms
Abnormalities in the Recovery Cycles and their Mechanisms
Effect of Myelin Sheath Aqueous Layers on the Excitability Properties of Simulated Hereditary and Chronic Demyelinating Neuropathies
Simulation of CMT1A, CIDP and CIDP Subtypes with Aqueous Layers within the Myelin Sheath
Effect of Myelin Sheath Aqueous Layers on the Potentials
Effect of Myelin Sheath Aqueous Layers on the Strength-Duration Time Constants, Rheobasic Currents
and Recovery Cycles
References
Index

Biography

Stephanova, Diana Ivanova; Kolev, Bozhidar Dimitrov

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