Deep Imaging in Tissue and Biomedical Materials: Using Linear and Nonlinear Optical Methods, 1st Edition (Hardback) book cover

Deep Imaging in Tissue and Biomedical Materials

Using Linear and Nonlinear Optical Methods, 1st Edition

Edited by Lingyan Shi, Robert R. Alfano

Jenny Stanford Publishing

524 pages | 76 Color Illus. | 105 B/W Illus.

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pub: 2017-04-03
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The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.


“This impressive volume represents a landmark publication on the use of optical methods for deep

biomedical imaging—a field that has been transformed by a variety of technical innovations in recent

years. Editors Shi and Alfano have secured contributions from top names in the field, for an extensive

compilation that comprehensively details the new state of the art, including forefront advances and

developments. Fully covering applications, methods and theory, this lavishly illustrated book is destined

to become a reference classic.” - Prof. David L. Andrews, University of East Anglia, UK

“This very timely book provides a highly comprehensive and very authoritative coverage of novel

imaging technologies using multimodal optical spectroscopy and light scattering, aimed towards

noninvasive deep tissue diagnostic and fundamental understanding of diseases such as cancers and

brain disorders. I highly recommend this book as an introductory guide on optical imaging for students,

as well as a valuable reference for scientists, engineers, and biomedical researchers who are seeking a

better understanding of deep optical imaging in biological tissues or biomaterials in life science

research.” - Prof. Paras N. Prasad, State University of New York at Buffalo, USA

“This is an excellent and up-to-date account of biomedical imaging research. The subject matter

includes the important topics of the field, including the necessary fundamental background such as

nonlinear optical processes and highly scattering optical phenomena. Each of the topics is well written

by the well-established subject matter experts, and the book is comprehensive and self-contained. The

background material is well integrated into the text with the important references included.” - Dr.

Daniel A. Nolan, Corning Inc., USA

"Drs. Shi and Alfano have expertly put together an extremely strong collection of chapters written by leaders in the field of deep imaging in biomedical materials. The technical material gives a thorough background as well as a broad view of the most state-of-the-art results worldwide. This book is a must-read for both active researchers in this field and students studying the topic."

—Prof. Alan E. Willner, University of Southern California, USA

Table of Contents

Overview of Second- and Third-Order Nonlinear Optical Processes for Deep Imaging

Sangeeta Murugkar and Robert W. Boyd

Complex Light Beams

Enrique J. Galvez

Gaussian Beam Optical Parameters in Multi-Photon Excitation Fluorescence Imaging

Lingyan Shi, Adrián Rodríguez-Contreras, and Robert R. Alfano

The Optics of Deep Optical Imaging in Tissues Using Long Wavelengths

Steven L. Jacques

Light Propagation and Interaction in Highly Scattering Media for Deep Tissue Imaging

W. B. Wang, Lingyan Shi, Luyao Lu, Laura A. Sordillo, L. Wang, S. K. Gayen, and R. R. Alfano

Application of Nonlinear Microscopy in Life Sciences

Zdenek Svindrych and Ammasi Periasamy

Smart Biomarker-Coated PbS Quantum Dots for Deeper Near-Infrared Fluorescence Imaging in the Second Optical Window

Takashi Jin, Akira Sasaki, and Yukio Imamura

Biomedical Applications in Probing Deep Tissue Using Mid-Infrared Supercontinuum Optical Biopsy

Angela B. Seddon

Light Propagation in Turbid Tissue-Like Scattering Media

Alexander Bykov, Alexander Doronin, and Igor Meglinski

Overview of the Cumulant Solution to Light Propagation Inside a Turbid Medium and Its Applications in Deep Imaging Beyond the Diffusion Approximation

Min Xu, Cai Wei, and Robert R. Alfano

Deep Imaging of Prostate Cancer Using Diffusion Reconstruction of Banana Paths with Near Infrared Prostatoscope Analyzer

Yang Pu, Wubao Wang, Min Xu, James A. Eastham, and Robert R. Alfano

Terahertz Propagation in Tissues and Its Thickness Limitation

Burcu Karagoz and Hakan Altan

Detection of Brain Tumors Using Stimulated Raman Scattering Microscopy

Spencer Lewis and Daniel Orringer

Chemical and Molecular Imaging of Deep Tissue through Photoacoustic Detection of Chemical Bond Vibrations

Yingchun Cao and Ji-Xin Cheng

Deep Tissue Imaging: Acoustic and Thermal Wave Propagation and Light Interactions in Tissue

Idan Steinberg, Asaf Shoval, Michal Balberg, Adi Sheinfeld, Michal Tepper, and Israel Gannot

Using the Transmission Matrix to Image Disordered Media

Matthieu Davy, Sylvain Gigan, and Azriel Z. Genack

About the Editors

Lingyan Shi is a research scientist at Columbia University, USA. Her current research focuses on metabolic imaging with stimulated Raman scattering microscopy. She was a research associate studying deep imaging and drug delivery in the brain at the Institute for Ultrafast Spectroscopy and Lasers, the City College of New York, USA, where she received her PhD in biomedical engineering.

Robert R. Alfano is a distinguished professor of science and engineering at the City College of New York. He has pioneered many applications of light and photonics technology to study biological, biomedical, and condensed matter systems using optical spectroscopy and imaging. He discovered and has used supercontinuum. Prof. Alfano is a fellow of the American Physical Society, the Optical Society, and the Institute of Electrical and Electronics Engineers.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
MEDICAL / Neurology
SCIENCE / Life Sciences / General