1st Edition

Dietary Modulation of Cell Signaling Pathways

Edited By Zigang Dong, Young-Joon Surh Copyright 2009
    504 Pages 4 Color & 65 B/W Illustrations
    by CRC Press

    A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Dietary Modulation of Cell Signaling Pathways reviews some of these findings, focusing on nutrient-gene interactions with particular emphasis on the intracellular signaling network.

    Explore a Pivotal Function for Maintaining Homeostasis

    The book addresses the dietary modulation of particular gene expression systems and highlights the underlying molecular and cellular mechanisms that involve upstream signaling molecules, such as kinases and transcription factors in the context of their therapeutic potential. It describes nutrients’ actions on the activation of an antioxidant and inflammatory transcription factor and the induction of their target gene expression.

    Provides a Mechanistic Understanding of the Action of Dietary Components

    Comprehensively covering dietary modulation of cell signaling, leading experts provide information on state-of-the-art research in their own specialty. For those working in the fields of dietary components, molecular mechanisms, and health benefits, this book presents a useful tool for mechanistic understanding of the action of dietary components.

    Modulation of Cell Signal Transduction by Chemopreventive Dietary Phytochemicals. Redox-Sensitive Transcription Factors as Prime Targets for Cellular Cytoprotection Afforded by Antioxidative and Anti-inflammatory Phytonutrients. Tumor-suppressing Effects of Antioxidants from Tea. Acetylcarnitine Induces Heme Oxygenase in Rat Astrocytes and Protects against Oxidative Stress: Role of the Transcription Factor Nrf2. Pharmacogenomics and Toxicogenomics of Cancer Chemopreventive Compounds, MAP Kinases/Nrf2 Transcription Factor. Oxidative Stress and Antioxidants in Chronic Obstructive Pulmonary Disease. Dietary Modulation of Oxidative Stress and Mucosal Damage. Microarray Profiling of Gene Expression Patterns in Glomerular Cells by Astaxanthin. Carotenoid Cleavage Enzymes I and II and PPgamma Expression in Various Tissues of F344 Rats Supplemented with Lycopene. Diets enriched in Omega 3 Fatty Acids Decrease the Amyloid Burden in a Mouse Model of Alzheimer's Disease. Antioxidant and Anticarcinogenic Effects of Selenium. Modulation of Hepatic Gene Expressionby a-Tocopherol in Cultured Cells and in Vivo. Nutrient Regulation of Cell Cycle Progression. Hyperlipidic Diets Induce Early Alterations of the Vitamin A Signaling Pathway in Rat Colonic Mucosa. The Role of Nutrition in Preventing Prostate Cancer: A Review of the Proposed Mechanism of Action of Various Dietary Substances. Introductory Remarks to the New Series of Reviews: From Dietary Antioxidatns to Regulators in Cellular Signaling and Gene Expression. Mechanisms of Genomic and Non-Genomics Action of Carotenoids. Cytoprotective Effects of Anthocyanins and Other Phelonics of Boysenberry and Blackcurrent on Dopamine and Amyloid b-induced Oxidative Stress in Transfected COS-7 Cells. How Relevant is In Vitro Antioxidant Activity? The Case of Ellagic Acid and Related Phenolic Acids. Multifunctional Catechins: Iron Chelators, Radical Scavengers, and PKC Activators in Neuroprotection. Molecular Mechanisms underlying Polyphenol-induced Cardioprotection. Protective Effect of Polyphenols on Vascular Diseases linked to Oxidative Stress. Human Serum collected after Red Wine Consumption Affects Transcription Factor Activation and Gene Expression in HUVEC. Comparative Quantificaiton of Pharmacodynamic Parameters of Chiral Compounds by Global Gene Expression Profiling. Modulation of Apoptotic Signaling by Carotenoids in Cancer Cells. Phytol Metabolites are Circulating Dietary Factors that Activate the Nuclear Receptor RXR. Cell Signaling Actions of Pomegranate Flavonoids. Lycopene Interferes with Cell Cycle Progression and Insulin-like Growth Factor I Signaling in Mammary Cancer Cells. Flavonoid Regulation of the Cell Cycle via Interactions within MAP Kinase and PI3 Kinase/Akt Signaling Cascades.


    Zigang Dong, Young-Joon Surh