Drug Delivery Fundamentals and Applications, Second Edition

Historical Introduction to the Field of Controlled Drug Delivery
Anya M. Hillery and Allan S. Hoffman

FUNDAMENTAL ISSUES

Principles of Controlled Release
Yvonne Perrie, Thomas Rades, and Kirsten Graeser

Improving the Water Solubility of Poorly Soluble Drugs
Kohsaku Kawakami and Anya M. Hillery

Overview of Epithelial Barriers
Floriane Laurent, Anya M. Hillery, and Randall Mrsny

PARENTERAL ROUTES FOR DRUG DELIVERY AND TARGETING

Nanotechnologies for Drug Delivery and Targeting: Opportunities and Obstacles
Alexander T Florence and Daan J. A. Crommelin

Long-Acting Injections and Implants
Jeremy C. Wright and James Matriano

NONPARENTERAL ROUTES FOR DRUG DELIVERY AND TARGETING

Oral Drug Delivery
Anya M. Hillery and David J. Brayden

Buccal and Sublingual Drug Delivery
Marc B. Brown and Viralkumar F. Patel

Transdermal Drug Delivery
Simon R. Corrie and Mark A. F. Kendall

Nasal Drug Delivery
Per Gisle Djupesland and Anya M. Hillery

Pulmonary Drug Delivery
Heidi M. Mansour, Paul B. Myrdal, Usir Younis, Priya Muralidharan, Anya M. Hillery, and Don Hayes, Jr.

Drug Delivery to the Female Reproductive Tract
Patrick F. Kiser, Justin T. Clark, and Jonathan T. Su

Ophthalmic Drug Delivery
Clive G Wilson, Mariam Badawi, Anya M. Hillery, Shyamanga Borooah, Roly Megaw, and Baljean Dhillon

EMERGING TECHNOLOGIES

Hydrogels
Ronald A. Siegel and Carmen Alvarez-Lorenzo

Drug Delivery to the Central Nervous System
Anya M. Hillery

Gene Delivery Systems
Kwang Suk Lim and Sung Wan Kim

Vaccine Delivery
Terry L. Bowersock and Suman M. Mahan

Theranostic Nanoagents
Anthony S. Malamas and Zheng-Rong Lu

Nanofabrication Techniques and Their Applications in Drug Delivery
Erica Schlesinger, Cade Fox, and Tejal Desai

TOWARD COMMERCIALIZATION

Rational Drug Discovery, Design, and Development
Haizhen A. Zhong, Osman F. Güner, and J. Phillip Bowen

Commercial and Regulatory Development Considerations for Nanomedicines
Donna Cabral-Lilly and Lawrence D. Mayer

Marketing Perspectives for Drug Delivery
Louise Rosenmayr-Templeton

Bringing Research to Clinical Application: Lessons from ThermoDox®: A Thermal Sensitive Liposome for Treatment of Cancer
David Needham

Conclusions
Anya M. Hillery and Kinam Park

Biography

Anya M. Hillery earned her BSc (Pharmacy) from Trinity College Dublin, Ireland, in 1990 and her PhD in pharmaceutics at the School of Pharmacy, Brunswick Square, University College London, UK. She continued her post-doctoral studies at the Square, then in 1995 took up a lectureship position in Pharmaceutical Sciences at the Department of Pharmacy, University of Brighton, UK. This was followed by a move in 1999 to Saint Louis University - Madrid Campus, Spain, where she currently lectures in the division of Health Sciences. She has previously served as Director of the Department of Science & Engineering, and Vice Dean, of SLU-Madrid. Kinam Park earned his PhD in pharmaceutics from the University of Wisconsin in 1983. After postdoctoral training in the Department of Chemical Engineering at the same university, he joined the faculty of the College of Pharmacy, Purdue University, in 1986 and was promoted to full Professor of Pharmaceutics in 1994. Since 1998, he has held a joint appointment in the Department of Biomedical Engineering and became Showalter Distinguished Professor of Biomedical Engineering in 2006. His research focuses on oral delivery, drug-device combination products, and microparticle delivery systems. He is the founder of Akina, Inc., specializing in polymers for drug delivery. He is currently the editor-in-chief of the Journal of Controlled Release.