2nd Edition
Drug Delivery Fundamentals and Applications, Second Edition
This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches.
Features:
- Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting
- Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting
- Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation
- Describes the most recent, emerging, and innovative technologies of drug delivery
- Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies
- Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies
Historical Introduction to the Field of Controlled Drug Delivery
Anya M. Hillery and Allan S. Hoffman
FUNDAMENTAL ISSUES
Principles of Controlled Release
Yvonne Perrie, Thomas Rades, and Kirsten Graeser
Improving the Water Solubility of Poorly Soluble Drugs
Kohsaku Kawakami and Anya M. Hillery
Overview of Epithelial Barriers
Floriane Laurent, Anya M. Hillery, and Randall Mrsny
PARENTERAL ROUTES FOR DRUG DELIVERY AND TARGETING
Nanotechnologies for Drug Delivery and Targeting: Opportunities and Obstacles
Alexander T Florence and Daan J. A. Crommelin
Long-Acting Injections and Implants
Jeremy C. Wright and James Matriano
NONPARENTERAL ROUTES FOR DRUG DELIVERY AND TARGETING
Oral Drug Delivery
Anya M. Hillery and David J. Brayden
Buccal and Sublingual Drug Delivery
Marc B. Brown and Viralkumar F. Patel
Transdermal Drug Delivery
Simon R. Corrie and Mark A. F. Kendall
Nasal Drug Delivery
Per Gisle Djupesland and Anya M. Hillery
Pulmonary Drug Delivery
Heidi M. Mansour, Paul B. Myrdal, Usir Younis, Priya Muralidharan, Anya M. Hillery, and Don Hayes, Jr.
Drug Delivery to the Female Reproductive Tract
Patrick F. Kiser, Justin T. Clark, and Jonathan T. Su
Ophthalmic Drug Delivery
Clive G Wilson, Mariam Badawi, Anya M. Hillery, Shyamanga Borooah, Roly Megaw, and Baljean Dhillon
EMERGING TECHNOLOGIES
Hydrogels
Ronald A. Siegel and Carmen Alvarez-Lorenzo
Drug Delivery to the Central Nervous System
Anya M. Hillery
Gene Delivery Systems
Kwang Suk Lim and Sung Wan Kim
Vaccine Delivery
Terry L. Bowersock and Suman M. Mahan
Theranostic Nanoagents
Anthony S. Malamas and Zheng-Rong Lu
Nanofabrication Techniques and Their Applications in Drug Delivery
Erica Schlesinger, Cade Fox, and Tejal Desai
TOWARD COMMERCIALIZATION
Rational Drug Discovery, Design, and Development
Haizhen A. Zhong, Osman F. Güner, and J. Phillip Bowen
Commercial and Regulatory Development Considerations for Nanomedicines
Donna Cabral-Lilly and Lawrence D. Mayer
Marketing Perspectives for Drug Delivery
Louise Rosenmayr-Templeton
Bringing Research to Clinical Application: Lessons from ThermoDox®: A Thermal Sensitive Liposome for Treatment of Cancer
David Needham
Conclusions
Anya M. Hillery and Kinam Park
Biography
Anya M. Hillery earned her BSc (Pharmacy) from Trinity College Dublin, Ireland, in 1990 and her PhD in pharmaceutics at the School of Pharmacy, Brunswick Square, University College London, UK. She continued her post-doctoral studies at the Square, then in 1995 took up a lectureship position in Pharmaceutical Sciences at the Department of Pharmacy, University of Brighton, UK. This was followed by a move in 1999 to Saint Louis University - Madrid Campus, Spain, where she currently lectures in the division of Health Sciences. She has previously served as Director of the Department of Science & Engineering, and Vice Dean, of SLU-Madrid. Kinam Park earned his PhD in pharmaceutics from the University of Wisconsin in 1983. After postdoctoral training in the Department of Chemical Engineering at the same university, he joined the faculty of the College of Pharmacy, Purdue University, in 1986 and was promoted to full Professor of Pharmaceutics in 1994. Since 1998, he has held a joint appointment in the Department of Biomedical Engineering and became Showalter Distinguished Professor of Biomedical Engineering in 2006. His research focuses on oral delivery, drug-device combination products, and microparticle delivery systems. He is the founder of Akina, Inc., specializing in polymers for drug delivery. He is currently the editor-in-chief of the Journal of Controlled Release.
