This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches.
Fundamental Issues. Introduction to Drug Delivery and Targeting Systems. Controlled Drug Release: history and future directions. Pharmacokinetics and Biopharmaceutics. Improving the water-solubility of poorly soluble drugs. An overview of epithelial barriers. Parenteral Routes of Drug Delivery and Targeting. Nanoparticles for targeted drug delivery. Challenges and obstacles to targeted drug delivery. Depot formulations. Non-Parenteral Routes of Drug Delivery and Targeting. Oral drug delivery: targeting in the GI tract. Buccal and sublingual drug delivery. Transdermal drug delivery. Nasal drug delivery. Pulmonary drug delivery. Vaginal drug delivery. Ophthalmic drug delivery. Emerging Technologies. Stimuli-sensitive drug delivery systems. Drug delivery to the CNS. Gene delivery systems. Vaccine delivery. Theranostic nanoagents. Nanotechnology in tissue engineering and regenerative medicine. Other Issues. Rational drug discovery, design and development. Regulatory & Safety Concerns. Marketing Perspectives.