2nd Edition

Drug Delivery Fundamentals and Applications, Second Edition

Edited By Anya Hillery, Kinam Park Copyright 2017
    632 Pages 211 Color Illustrations
    by CRC Press

    632 Pages
    by CRC Press

    This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches.


    • Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting
    • Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting
    • Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation
    • Describes the most recent, emerging, and innovative technologies of drug delivery
    • Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies
    • Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies

    Historical Introduction to the Field of Controlled Drug Delivery
    Anya M. Hillery and Allan S. Hoffman


    Principles of Controlled Release
    Yvonne Perrie, Thomas Rades, and Kirsten Graeser

    Improving the Water Solubility of Poorly Soluble Drugs
    Kohsaku Kawakami and Anya M. Hillery

    Overview of Epithelial Barriers
    Floriane Laurent, Anya M. Hillery, and Randall Mrsny


    Nanotechnologies for Drug Delivery and Targeting: Opportunities and Obstacles
    Alexander T Florence and Daan J. A. Crommelin

    Long-Acting Injections and Implants
    Jeremy C. Wright and James Matriano


    Oral Drug Delivery
    Anya M. Hillery and David J. Brayden

    Buccal and Sublingual Drug Delivery
    Marc B. Brown and Viralkumar F. Patel

    Transdermal Drug Delivery
    Simon R. Corrie and Mark A. F. Kendall

    Nasal Drug Delivery
    Per Gisle Djupesland and Anya M. Hillery

    Pulmonary Drug Delivery
    Heidi M. Mansour, Paul B. Myrdal, Usir Younis, Priya Muralidharan, Anya M. Hillery, and Don Hayes, Jr.

    Drug Delivery to the Female Reproductive Tract
    Patrick F. Kiser, Justin T. Clark, and Jonathan T. Su

    Ophthalmic Drug Delivery
    Clive G Wilson, Mariam Badawi, Anya M. Hillery, Shyamanga Borooah, Roly Megaw, and Baljean Dhillon


    Ronald A. Siegel and Carmen Alvarez-Lorenzo

    Drug Delivery to the Central Nervous System
    Anya M. Hillery

    Gene Delivery Systems
    Kwang Suk Lim and Sung Wan Kim

    Vaccine Delivery
    Terry L. Bowersock and Suman M. Mahan

    Theranostic Nanoagents
    Anthony S. Malamas and Zheng-Rong Lu

    Nanofabrication Techniques and Their Applications in Drug Delivery
    Erica Schlesinger, Cade Fox, and Tejal Desai


    Rational Drug Discovery, Design, and Development
    Haizhen A. Zhong, Osman F. G├╝ner, and J. Phillip Bowen

    Commercial and Regulatory Development Considerations for Nanomedicines
    Donna Cabral-Lilly and Lawrence D. Mayer

    Marketing Perspectives for Drug Delivery
    Louise Rosenmayr-Templeton

    Bringing Research to Clinical Application: Lessons from ThermoDox®: A Thermal Sensitive Liposome for Treatment of Cancer
    David Needham

    Anya M. Hillery and Kinam Park


    Anya M. Hillery earned her BSc (Pharmacy) from Trinity College Dublin, Ireland, in 1990 and her PhD in pharmaceutics at the School of Pharmacy, Brunswick Square, University College London, UK. She continued her post-doctoral studies at the Square, then in 1995 took up a lectureship position in Pharmaceutical Sciences at the Department of Pharmacy, University of Brighton, UK. This was followed by a move in 1999 to Saint Louis University - Madrid Campus, Spain, where she currently lectures in the division of Health Sciences. She has previously served as Director of the Department of Science & Engineering, and Vice Dean, of SLU-Madrid. Kinam Park earned his PhD in pharmaceutics from the University of Wisconsin in 1983. After postdoctoral training in the Department of Chemical Engineering at the same university, he joined the faculty of the College of Pharmacy, Purdue University, in 1986 and was promoted to full Professor of Pharmaceutics in 1994. Since 1998, he has held a joint appointment in the Department of Biomedical Engineering and became Showalter Distinguished Professor of Biomedical Engineering in 2006. His research focuses on oral delivery, drug-device combination products, and microparticle delivery systems. He is the founder of Akina, Inc., specializing in polymers for drug delivery. He is currently the editor-in-chief of the Journal of Controlled Release.