After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful and marketable nanoformulation.
- Offers a general overview of the entire process involved in the synthesis and characterization of pharmaceutical nanoparticles
- Covers a broad range of synthetic materials for developing nanoformulations customized for specific disease states, target organs, and drugs
- Every chapter sequentially builds, providing a progressive pathway from classical nanoparticles to the more advanced to be used as a full drug product by consumers
- Provides information in a bottom-up manner in that definitions and explanations of relevant background information serve as a framework for understanding advanced concepts
This user-friendly reference is aimed at materials engineers, chemical engineers, biomedical engineers, pharmaceutical scientists, chemists, and others working on advanced drug delivery, from academia as well as industry.
Table of Contents
1. Introduction to Nanomaterials for Drug Delivery
Akhlesh Kumar Jain and Keerti Mishra
2. Manufacturing Techniques for Nanoparticles in Drug Delivery
Daniel Real, María Lina Formica, Matías L. Picchio, and Alejandro J. Paredes
3. Pharmacokinetics of Nanomaterials/Nanomedicines
Mulham Alfatama and Zalilawati Mat Rashid
4. Bioinspired Nano-Formulations: Materials, Approaches, and Applications in Drug Delivery
Jahanzeb Mudassir and Muhammad Sohail Arshad
5D-Printed Nanocrystals for Oral Administration of the Drugs
Lucía Lopez-Vidal, Daniel Andrés Real, Alejandro J. Paredes, Juan Pablo Real, and Santiago Daniel Palma
6. Functional Nanomaterials
Imran Saleem, Yousef Rasmi, Leyla Fath-Bayati, and Zohreh Arabpour
7. Trigger-Sensitive Nanoparticle for Drug Delivery.
Hadiqa Nazish Raja, Basalat Imran, and Fakhar Ud Din
8. Metal Organic Frameworks for Drug Delivery
Saima Zulﬁqar, Shahzad Sharif, and Muhammad Yar
9. Graphene and Graphene-Based Nanomaterials: Current Applications and Future Perspectives
Abid Hussain, Yuhua Weng, and Yuanyu Huang
10. Nanomaterials for Lungs Targeting
Keerti Mishra and Akhlesh Kumar Jain
11. Nanostructured Drug Carriers for Nose-to-Brain Drug Delivery: A Novel Approach for Neurological Disorders
Talita Nascimento da Silva, Emanuelle Vasconcellos de Lima, Anna Lecticia Martinez Martinez Toledo, Julia H. Clarke, and Thaís Nogueira Barradas
12. Carbon Nanotubes in Cancer Therapy
Renu Sankar, V.K. Ameena Shirin, Chinnu Sabu, and K. Pramod
13. Applications of Silica-Based Nanomaterials for Combinatorial Drug Delivery in Breast Cancer Treatment
Mubin Tarannum and Juan L. Vivero-Escoto
14. Cationic Gemini Surfactants as Genes and Drug Carriers
Mays Al-Dulaymi, Anas El-Aneed, and Ildiko Badea
15. Stability of Nanomaterials
Mulham Alfatama, Ahmed R. Gardouh, and Abd Almonem Doolaane
16. Nanotoxicology and Regulatory Aspects of Nanomaterials and Nanomedicines
Nashwa Osman and Imran Saleem
Dr. Yasser Shahzad is an Assistant Professor at Department of Pharmacy, COMSATS University Islamabad (CUI), Lahore Campus. Dr. Yasser won a prestigious Nicholson Scholarship to pursue PhD from University of Huddersfield, UK. He also remained a Postdoctoral Fellow at PHARMACEN, North-West University South Africa. He has a particular interest in advanced drug delivery research at the interface of pharmaceutics, chemistry and cosmetics, and publishes regularly in internationally recognized peer-reviewed journals. He has authored more than 60 research publications in high quality international journals, including three book chapters in books published by CRC Press, Springer Nature and Wiley. He also serves as Editorial Board member of various international journals. Dr. Yasser holds active research collaborations with various international universities in UK, US and South Africa.
Dr. Syed A.A. Rizvi is Assistant Professor, Pharmaceutical Sciences, Hampton University. He has published over 200 peer-reviewed articles, including journal publications, book chapters, books, US patents, and oral/poster presentations. He also serves on the Editorial Boards/Panels of different journals (in various capacities) and review manuscripts and books for over 150 well known scientific publications (journals and books). Dr. Rizvi enjoys teaching and engaging students in thought process, beside creative cooking at home and practicing martial arts (1st degree black belt in Okinawan Goju Ryu Karate).
Dr. Abid Mehmood Yousaf is presently working as an Assistant Professor of Pharmacy at Department of Pharmacy, COMSATS University Islamabad, Lahore campus. Before this, he has also worked for more than two years at the same position in the Faculty of Pharmacy, University of Central Punjab, Lahore. He has earned his degree of Doctor of Pharmacy (Pharm-D) from University of the Punjab in 2009. In 2011, he was enrolled in MS-PhD program at College of Pharmacy, Hanyang University, South Korea. He has performed his research in the Lab of Physical & Industrial Pharmacy under the supervision of Prof. Dr. Han-Gon Choi, a distinguished professor of Pharmacy in South Korea. He was awarded with the degree of PhD in Pharmacy in 2015. Dr. Abid has numerous publications in peer-reviewed SCI journals of pharmacy. He has presented his research work at several international conferences abroad. He vows to continue research in the same field and train young pharmacist researchers.
Dr. Talib Hussain has been working as Assistant Professor in Department of Pharmacy, COMSATS University Islamabad (CUI), Lahore campus since 2018. Prior to join CUI, he served in Primary & Secondary Health Department Punjab as Deputy Drug Controller/ Provincial Drug Inspector. He obtained Pharmacy (2006) and M. Phil (2009) degrees from Bahauddin Zakariya University Multan. He received his PhD in Pharmacy from University of Huddersfield, UK in 2014. Primary research work of his PhD was based on formulation development of poorly soluble drugs through bespoke Microwave technique. Moreover, isothermal titration calorimetry was employed to investigate the drug-excipient compatibility. Over the years, he has developed active collaborations and expertise in the field of drug delivery such as solid dispersions, nano-particles, micro-emulsions, liposomes, hydrogels for oral as well as for topical drug delivery systems. He has published more than 40 articles in the form of original research, reviews and book chapters.