Drug Stereochemistry: Analytical Methods and Pharmacology, Third Edition, 3rd Edition (Hardback) book cover

Drug Stereochemistry

Analytical Methods and Pharmacology, Third Edition, 3rd Edition

Edited by Krzysztof Jozwiak, W. J. Lough, Irving W. Wainer

CRC Press

332 pages | 29 B/W Illus.

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pub: 2012-04-23
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Description

Drug Stereochemistry: Analytical Methods and Pharmacology, Third Edition covers all aspects of chiral drugs from academic, governmental, industrial, and clinical perspectives, reflecting the many advances in techniques and methodology.

Topics include:

  • The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery
  • How stereochemistry impacts decisions made in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) stages of drug discovery
  • Pharmacokinetics and pharmacodynamics and the issues faced during the final stages of the drug development process
  • The impact of the International Conference on Harmonisation (ICH) on the use of single isomer drugs
  • Chiral switches
  • The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs
  • Patent issues surrounding chiral switches and the marketing of single enantiomer switches

The book provides a solid background on stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. It is a one-stop reference for pharmaceutical scientists and chemists working with chiral drug molecules.

Table of Contents

INTRODUCTION

The early history of stereochemistry: From the discovery of molecular asymmetry and the first resolution of a racemate by Pasteur to the asymmetrical chiral carbon of van’t Hoff and Le Bel, Dennis E. Drayer

Stereochemistry—basic terms and concepts, Krzysztof Jo´z´wiak

Molecular basis of chiral recognition, Krzysztof Jo´z´wiak

PART II: THE SEPARATION, PREPARATION, AND IDENTIFICATION OF

STEREOCHEMICALLY PURE DRUGS

Separation and resolution of enantiomers and their dissociable diastereomers through direct crystallization, Harry G. Brittain

Indirect methods for the chromatographic resolution of drug enantiomers, Władysław Gołkiewicz and Beata Polak

HPLC chiral stationary phases for the stereochemical resolution of enantiomeric compounds: The current state of the art, W. John Lough

Preparative and production scale chromatography in enantiomer separations, Geoffrey B. Cox

Enantioselective separations by electromigration techniques, Michał J. Markuszewski

Alternative analytical techniques for determination or isolation of drug enantiomers, W. John Lough

PART III: PHARMACOKINETIC AND PHARMACODYNAMIC

DIFFERENCES BETWEEN DRUG STEREOISOMERS

Stereoselective transport of drugs, Prateek Bhatia and Ruin Moaddel

Enantioselective binding of drugs to plasma proteins, Thomas H. Kim

Clinical pharmacokinetics and pharmacodynamics of stereoisomeric drugs, Scott A. Van Wart and Donald E. Mager

PART IV: PERSPECTIVES ON THE DEVELOPMENT AND USE OF SINGLE

ISOMER DRUGS

Regulatory perspective on the development of new stereoisomeric drugs, Sarah K. Branch and Andrew J. Hutt

Molecular analysis of agonist stereoisomers at b2-adrenoceptors, Roland Seifert and Stefan Dove

Development of chiral drugs from a U.S. legal patentability perspective:Enantiomers and racemates, Svetlana M. Ivanova

The importance of chiral separations in single enantiomer patent cases, Charlotte Weekes

Index

About the Editor

Professor Krzysztof Józwiak is head of laboratory of medicinal chemistry and neuroengineering of Medical University of Lublin, Poland

Dr W John Lough is reader in pharmaceutical analysis in the Department of Pharmacy, Health and Well-Being at the University of Sunderland, UK

Irving W. Wainer, Ph.D. is senior investigator, in the Bioanalytical Chemistry and Drug Discovery Section, Laboratory for Clinical Investigation, National Institute of Aging/National Institutes of Health

About the Series

Drugs and the Pharmaceutical Sciences

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
MED072000
MEDICAL / Pharmacy