Elastic Fiber Matrices: Biomimetic Approaches to Regeneration and Repair provides a comprehensive resource on the intrinsic and pathological aberrations of the complex process of elastic matrix assembly and/or variations thereof in different elastic tissue types, and on strategies to regenerate or restore lost elastin matrix, either in vitro or in vivo, including biomimetic elastin-like-peptides, gene therapy, drug delivery, tissue engineering (biomolecules, scaffolds, and mechanical stimuli), pharmacological approaches, elastin stabilization and preservation, stem cell therapy, allografts/xenografts, and synthetic/biological elastomers.
Comprised of individual chapters contributed by leading researchers and scientists in the field, the text details current approaches for elastin matrix regeneration and repair, identifying their various advantages and limitations while offering valuable insight into emerging trends. Thus, this book is a must-have guide for academicians and industry professionals working in the areas of connective tissue biology, tissue engineering, dermal and cardiovascular biomaterials, and drug delivery.
Table of Contents
Assembly and Properties of Elastic Fibers
Christian E. H. Schmelzer
Pathology of the Elastic Matrix
Beth A. Kozel and Dirk Hubmacher
Richard Wang, Suzanne M. Mithieux, Jazmin Ozsvar, and Anthony S. Weiss
Biomolecular Regulation of Elastic Matrix Regeneration and Repair
Ganesh Swaminathan, Balakrishnan Sivaraman, and Anand Ramamurthi
Scaffold and Biomechanical Transductive Approaches to Elastic Tissue Engineering
Nian Shen, Svenja Hinderer, and Katja Schenke-Layland
Pharmacologic Strategies for Preserving Elastic Matrix
Nasim Nosoudi, Vaideesh Parasaram, Saketh R. Karamched, Aniqa Chowdhury, and Naren Vyavahare
Sourcing and Manipulating Stem Cells for Elastin Regeneration Applications
Brian M. Balog, Anand Ramamurthi, and Margot S. Damaser
Regulating Elastogenesis Using Proteoglycans
Mervyn J. Merrilees, Inkyung Kang, Aleksander Hinek, and Thomas N. Wight
Recent Approaches and Future Perspectives on Elastin Regeneration and Repair
Jyotsna Joshi and Chandrasekhar Kothapalli
Anand Ramamurthi is an associate professor of molecular medicine and biomedical engineering at the Cleveland Clinic, with adjunct appointments at the University of Akron (Integrated Biosciences Program), and Case Western Reserve University (BME). In 1999, he earned his PhD in chemical engineering from Oklahoma State University in Stillwater, and subsequently completed a postdoctoral fellowship at the Cleveland Clinic funded by an award from the American Heart Association (AHA). Prior to 2010, Dr. Ramamurthi was a tenured faculty in the Departments of Bioengineering at Clemson University and Regenerative Medicine and Cell Biology at the Medical University of South Carolina in Charleston, respectively. For the past 13 years, he has directed a research program that focuses on developing technologies for enabling biomimetic regeneration and repair of extracellular matrix (ECM) structures, specifically the poorly regenerated elastic matrix component, both in vitro, and in situ at sites of chronic matrix disruption (e.g., aortic aneurysms and pelvic organ prolapse). His research has resulted in several book chapters, 50 peer-reviewed publications in top journals in the biomaterials, tissue engineering, and regenerative medicine fields, nearly 200 conference abstracts and proceedings, and several awarded and filed patents. His research has been funded by the National Institutes of Health (NIH), National Science Foundation (NSF), AHA, and industry. Dr. Ramamurthi is a member of several international professional societies in the cardiovascular sciences, biomaterials, and tissue engineering fields. He is a professional member of the AHA Council on arteriosclerosis, thrombosis, and vascular biology, and is an elected fellow of the AHA Council on basic cardiovascular sciences. He serves on several national committees such as that of the North American Vascular Biology Organization, on the editorial board of several scientific journals in the fields of tissue engineering, regenerative medicine, and vascular biomedicine, and actively reviews for the NIH, NSF, AHA, and several international scientific funding agencies, and nearly 40 journals including Tissue Engineering, Biomaterials, and Acta Biomaterialia. He serves on the external advisory committee of the NIH-supported Center for Biomedical Research Excellence (COBRE) in biomaterials for tissue regeneration in South Carolina, and on the Inventions Peer Review Committee of Cleveland Clinic Innovations, the commercialization wing of the Cleveland Clinic. Dr. Ramamurthi has been an invited speaker at several national conferences, and in 2007, he was the featured investigator at the Biomedical Entrepreneurship Meeting of the Upstate South Carolina Biomedical Cluster.
Chandrasekhar Kothapalli is a tenured Associated Professor in the Department of Chemical and Biomedical Engineering at the Cleveland State University (CSU). He also holds adjunct appointments in the Department of Biomedical Engineering at the Lerner Research Institute in Cleveland Clinic, and in the Division of General Medical Sciences at the Case Western Reserve University School of Medicine. He earned his PhD in bioengineering from the Clemson University-Medical University of South Carolina joint program in 2008, and performed postdoctoral work in the Biological Engineering Department at the Massachusetts Institute of Technology and in the Biomedical Engineering Department at the City University of New York. His research interests are in tissue engineering, matrix biology, microfluidics, simulations and modeling, axonal biology, toxicology, stem cells, and cancer cell biology. Dr. Kothapalli’s research has resulted in one approved and two filed patents, 32 peer-reviewed journal publications and conference proceedings, four book chapters, and more than 60 conference abstracts and presentations. He is an active member of numerous professional societies in biomedical and materials science fields and serves as a reviewer for numerous federal and private funding agencies, conferences, and journals. Among his honors, he was a recipient of the Faculty Merit Award from CSU in 2013 and 2014, a member of Sigma XI, and the presidential scholar at the Medical University of South Carolina. His current research is supported by the US National Institutes of Health (NIH), National Science Foundation (NSF), and institutional funds.
"… focuses on strategies to preserve and repair elastic matrix, which is an important but often overlooked area for many regenerative medicine and tissue engineering applications. This book also provides a detailed reference about elastic matrix biology that includes new research in this developing area."
—Chris Bashur, Florida Institute of Technology, Melbourne, USA
"This interesting book focused on the strategies used for preserving and repairing the eslastic matrix, represents an important resource of knowledge for both specialists and non specialists who wish to enter in the fascinating field of the regenerative medicine. Thus is has to stay in the library of academicians and industry professionals who directly or indirectly are interested to the biology and regeneration of the skin health, aged, photoaged, or affected by different kind of diseases."
—P. Morganti, Editor-in-Chief, Journal of Applied Cosmetology