Elastic Fiber Matrices: Biomimetic Approaches to Regeneration and Repair provides a comprehensive resource on the intrinsic and pathological aberrations of the complex process of elastic matrix assembly and/or variations thereof in different elastic tissue types, and on strategies to regenerate or restore lost elastin matrix, either in vitro or in vivo, including biomimetic elastin-like-peptides, gene therapy, drug delivery, tissue engineering (biomolecules, scaffolds, and mechanical stimuli), pharmacological approaches, elastin stabilization and preservation, stem cell therapy, allografts/xenografts, and synthetic/biological elastomers.
Comprised of individual chapters contributed by leading researchers and scientists in the field, the text details current approaches for elastin matrix regeneration and repair, identifying their various advantages and limitations while offering valuable insight into emerging trends. Thus, this book is a must-have guide for academicians and industry professionals working in the areas of connective tissue biology, tissue engineering, dermal and cardiovascular biomaterials, and drug delivery.
Assembly and Properties of Elastic Fibers
Christian E. H. Schmelzer
Pathology of the Elastic Matrix
Beth A. Kozel and Dirk Hubmacher
Richard Wang, Suzanne M. Mithieux, Jazmin Ozsvar, and Anthony S. Weiss
Biomolecular Regulation of Elastic Matrix Regeneration and Repair
Ganesh Swaminathan, Balakrishnan Sivaraman, and Anand Ramamurthi
Scaffold and Biomechanical Transductive Approaches to Elastic Tissue Engineering
Nian Shen, Svenja Hinderer, and Katja Schenke-Layland
Pharmacologic Strategies for Preserving Elastic Matrix
Nasim Nosoudi, Vaideesh Parasaram, Saketh R. Karamched, Aniqa Chowdhury, and Naren Vyavahare
Sourcing and Manipulating Stem Cells for Elastin Regeneration Applications
Brian M. Balog, Anand Ramamurthi, and Margot S. Damaser
Regulating Elastogenesis Using Proteoglycans
Mervyn J. Merrilees, Inkyung Kang, Aleksander Hinek, and Thomas N. Wight
Recent Approaches and Future Perspectives on Elastin Regeneration and Repair
Jyotsna Joshi and Chandrasekhar Kothapalli
"… focuses on strategies to preserve and repair elastic matrix, which is an important but often overlooked area for many regenerative medicine and tissue engineering applications. This book also provides a detailed reference about elastic matrix biology that includes new research in this developing area."
—Chris Bashur, Florida Institute of Technology, Melbourne, USA
"This interesting book focused on the strategies used for preserving and repairing the eslastic matrix, represents an important resource of knowledge for both specialists and non specialists who wish to enter in the fascinating field of the regenerative medicine. Thus is has to stay in the library of academicians and industry professionals who directly or indirectly are interested to the biology and regeneration of the skin health, aged, photoaged, or affected by different kind of diseases."
—P. Morganti, Editor-in-Chief, Journal of Applied Cosmetology