1st Edition
Emerging Materials and Technologies for Bone Repair and Regeneration
This book covers advancements in the field of bone repair and regeneration. It introduces bone development, repair, and regeneration and details different biomaterials and technologies involved in the fabrication and characterization of bone-related scaffolds and implants. The book explores nanotechnological intervention and folklore phytomedicines and their prospects in regenerating bone including major bone related disease conditions, infection, and their tackling via tissue engineering strategies.
FEATURES:
- covers polymer materials and technologies for bone repair and regeneration based on tissue engineering
- defines the interdisciplinary mechanism of bone tissue repair ranging from the fields of material science, nanotechnology, and phytomedicine includes basic sciences, scaffolds, and bone infection
- examines fabrication and characterization methods for the bone repair materials
- reviews fundamentals of interlinked mechanisms of bone development, repair, and regeneration.
This book is aimed at graduate students and researchers in biomedical and tissue engineering and biomaterial sciences.
I Introduction: The Synthesis and Characterization of Biomaterials for Bone Regeneration
Chapter 1 Cellular and Molecular Interplay in Bone Homeostasis and Healing
Deepak Bushan Raina
Chapter 2 Choice and Selection of Biomaterials for Bone Repair
Andreas K Nüssler and Sabrina Ehnert
Chapter 3 Synthetic Bone Analogue Materials and Design for Skeletal Tissue Healing
Samir Das, Mitali Mishra, Kanta Chakraborty, Sayan Das, Baisakhee Saha, and Santanu Dhara
Chapter 4 Integrating 3D Printing and Electrospinning to Fabricate Scaffolds for Bone Regeneration
Didem Demir, Ashok Vaseashta, and Nimet Bölgen
Chapter 5 The 3D/4D Printing of Polymeric Scaffolds for Bone Tissue Engineering
Arkodip Mandal and Kaushik Chatterjee
Chapter 6 Recent Advances in Biodegradable Implants in Bone Tissue Engineering
Shazia Shaikh, Rupita Ghosh, Ashiq Hussain Pandit, Shreya Mehrotra, and Ashok Kumar
Chapter 7 Recent Advances in Characterization Techniques for Bone Substitutes
Aman Nikhil and Ashok Kumar
II Application of Nanotechnology and Phytomedicines for Bone Repair and Regeneration
Chapter 8 Spatially Controlled Delivery of Bioactive Cues for Bone Tissue Engineering: From Nano to Macro Scale
Chandra Khatua, Eshita Mukherjee, and Debrupa Lahiri
Chapter 9 Nanotechnology Advancements for Improved Bone Metabolism, Regeneration and Treatment of Bone Diseases
Vianni Chopra, Diana Arredondo Bernal, Gaurav Chauhan, Sergio Omar Martinez Chapa, and Deepa Ghosh
Chapter 10 Osteoblast and Osteoclast Crosstalk during Osteo-Homeostasis and Biotherapeutic Interventions
Harishkumar Madhyastha, Radha Madhyastha, Kaushita Banerjee, Yuichi Nakajima, Masugi Maruyama, and Nozomi Watanabe
Chapter 11 Modulatory Effects of Phytobioactives in Bone Metabolism and Regeneration
Archita Gupta, Rahul Deka, Sanjay Kumar Mehta, Kanishka Kunal, and Sneha Singh
III Advancement and Application of Tissue Engineering toward Orthopedic Concerns
Chapter 12 Unraveling Translational Research on Ultra-High Molecular Weight Polyethylene in Total Hip Joint Arthroplasty: A Lab-to-Industry-Scale Pilot Study
Vidushi Sharma, N. H. Gowtham, Biswanath Kundu, Vamsi Krishna Balla, D.C. Sundaresh, and Bikramjit Basu
Chapter 13 The Physiology of Bone Homeostasis to Aid Experimental Therapeutics in Disease Conditions
Konica Porwal and Naibedya Chattopadhyay
Chapter 14 Biomimetic Bone Models in Advancing Bone Regeneration and Repair
Tanjot Kaur, Sandhya Natesan, Mayank Singh, and Greeshma Thrivikraman
Chapter 15 Biomaterials and Their Carriers for Managing Bone Disorders
Erdem Aras Sezgin
Chapter 16 Next-Generation Theranostic Tools for Bone Repair and Skeletal Metabolism with Exosomes
Sneha Gupta, Prerna Singh, and Ashok Kumar
Chapter 17 Clinically Relevant Bone Diseases and Bone Fracture Animal Models
Irfan Qayoom, Ekta Srivastav, and Ashok Kumar
Chapter 18 Advanced Biomaterial-Based Strategies for Intervertebral Disc Repair and Regeneration
Akash Yadav, Raghavendra Dhanenawar, and Akshay Srivastava
Chapter 19 Osteoarthritis Pain and Current Therapeutic Strategies
Erick Orozco Morato and Lakshmi S. Nair
Biography
Prof. Ashok Kumar is a chair professor of bioengineering at the Department of Biological Sciences and Bioengineering, Indian Institute of Technology (IIT), Kanpur, India. He received his Ph.D. in Biotechnology from IIT Roorkee. He conducted his postdoctoral research at Nagoya University, Japan, and Lund University, Sweden. He has published more than 230 research papers, edited five books, has many patents granted/filed, and has transferred technologies to industry. His areas of research interest include biomaterials, tissue engineering, regenerative medicine, bioprocess engineering, and environmental biotechnology. Prof. Kumar has been conducting active national and international research collaborations and has been recognized with various awards and appreciations for his outstanding research contributions.
Dr. Sneha Singh is an assistant professor in the Department of Bioengineering and Biotechnology at Birla Institute of Technology, Mesra, Ranchi, India (BIT Mesra). She received her Ph.D. in the domain of nanobiotechnology from BIT. She has published many peer-reviewed research papers, book chapters, edited books, and patents to her credit. Her research interests span nanobiotechnology, biomaterials and tissue engineering, phytomedicines, antimicrobials and regenerative medicine specializing in nanomaterials, phytobioactives, and smart biomaterials for biomedical applications while conducting active research collaborations with eminent institutions nationally and internationally.
Dr. Prerna Singh is currently a postdoctoral fellow in the Department of Biological Sciences and Bioengineering, IIT Kanpur, India. She received her Ph.D. in biotechnology from Banaras Hindu University, India, in 2017. Her research areas include biomaterials, tissue engineering, regenerative medicine, stem cell research, and phytomedicine. She has significant peerreviewed research articles, granted patent, book chapters and edited issues in journals among her scientific accomplishments. She is presently working in the area of biocompatible scaffolds for bone and soft tissue engineering. She has been involved in international and national collaborative research work with Aalto University, Finland; IIT Delhi; SKUAST, Kashmir; BIT Mesra, and BHU.
