Endothelin Receptors: From the Gene to the Human, 1st Edition (Hardback) book cover

Endothelin Receptors

From the Gene to the Human, 1st Edition

By Robert R. Ruffolo, Jr.

CRC Press

304 pages

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Hardback: 9780849359385
pub: 1995-05-19
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Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans.

This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.


"This book is recommended as an addition to the libraries of institutions and individual researchers actively studying the physiological and/or pathophysicological role of endothelin."

- J. Med. Chem., 1996, 39(3)

Table of Contents

Introduction: Endothelin Receptors, E.H. Ohlstein and R.R. Ruffolo, Jr.

Endothelin Receptor Subclassification, E.H. Ohlstein, P. Nambi, and R.R. Ruffolo, Jr.

Molecular Biology of Endothelin Receptors, D.J. Bergsma, N. Elshourbagy, and C. Kumar

Signal Transduction Processes Involved in Endothelin-Mediated Responses, P. Nambi, C. Kumar, and E.H. Ohlstein

Endothelin Receptor Antagonists, J.D. Elliott, M.A. Lago, and C.E. Peishoff

Functions Mediated by Peripheral Endothelin Receptors, E.H. Ohlstein, S. Douglas, D.P. Brooks, D.W.P. Hay, G.Z. Feuerstein, and R.R. Ruffolo, Jr.

Endothelin in the Central Nervous System, R.N. Willette, G.Z. Feuerstein, and F.C. Barone

The Role of Endothelin in Human Disease: Implications and Potential Therapeutic Intervention, D.K. Jorkasky, D.W.P. Hay, and M.I. Freed


About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / Biology / Molecular Biology
SCIENCE / Life Sciences / General