Revised and expanded, this blue-ribbon reference emphasizes the latest developments in the identification, utilization, and analysis of flavonoids for the prevention of disease and maintenance of good health. The book examines the processes involved in the absorption, metabolism, distribution, and excretion of these compounds and the impact of biotransformation on flavonoid function.The Second Edition contains new discussions on the potential of dietary flavonoids to attenuate neurological dysfunction and degeneration, developments in gene expression and genomics for identification of therapeutic targets and markers of disease, and the mechanisms regulating flavonoid bioavailability.
Part I: Occurrence and Analysis 1. Phenolic Acids in Fruits and Vegetables 2. Flavonoids in Herbs 3. The Relationship between the Phenolic Composition and the Antioxidant Activity of Fruits and Vegetables Part II: Characterization, Chemical, and Biological Properties 4. Applications of Flavonoid Analysis and Identification Tech-niques: Isoflavones (Phytoestrogens) and 3-Deoxyanthocyanins 5. Synthesis, Identification, Quantification and Chemical Reactivity of Methylated Flavan-3-ols 6. Investigation of Flavonoids and Their in Vivo Metabolite Forms Using Tandem Mass Spectrometry 7. Effects of Flavonoids on the Oxidation of Low-Density Lipoprotein and Atherosclerosis Part III: Cell Interactions in Vivo and in Vitro 8. Phytochemicals and Brain Aging: A Multiplicity of Effects 9. Flavonoids: Neuroprotective Agents? Modulation of Oxi-dative Stress-Induced MAP Kinase Signal Transduction 10. Mitochondrial Actions of Flavonoids and Isoflavonoids 11. Gene Modulation of HaCaT Cells Induced by Pine Bark Extract 12. Cytoprotective and Cytotoxic Effects of Flavonoids Part IV: Absorption, Metabolism, and Bioavailability 13. Understanding the Bioavailability of Flavonoids through Studies in Caco-2 Cells 14. Metabolism in the Small Intestine and Gastrointestinal Tract 15. Absorption of Quercetin Glycosides 16. Bioavailability of Flavanol Monomers 17. Absorption and Metabolism of Hydroxycinnamates