Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design.
This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
Table of Contents
Pulse Sequence Considerations and Schemes
Cornelius Faber and Florian Schmid
Advanced Detection Techniques and Hardware: Simultaneous 19F/1H MRI
Lingzhi Hu, Jochen Keupp, Shelton D. Caruthers, Matthew J. Goette, Gregory M. Lanza, and Samuel A. Wickline
Hyperpolarization for Signal Enhancement in Fluorine MR Applications
Ute Bommerich, Johannes Bernarding, Denise Lego, Thomas Trantzschel, and Markus Plaumann
19F IMAGING AGENTS
Active Targeting of Perfluorocarbon Nanoemulsions
Sebastian Temme, Christoph Grapentin, Tuba Güden-Silber, and Ulrich Flögel
Responsive Probes for 19F MRS/MRI
Aneta Keliris, Klaus Scheffler, and Jörn Engelmann
Imaging Acute Organ Transplant Rejection with 19F MRI
T. Kevin Hitchens, Lesley M. Foley, and Qing Ye
Ruud B. van Heeswijk, Christine Gonzales, and Juerg Schwitter
MONITORING OF SPECIFIC CELL POPULATIONS
Tracking Lymphocytes in vivo
Ghaith Bakdash and Mangala Srinivas
Tracking of Dendritic Cells
Sonia Waiczies, MinChi Ku, and Thoralf Niendorf
Neural Stem Cells
Markus Aswendt, Philipp Boehm-Sturm, and Mathias Hoehn
Fluorinated Natural Compounds and Synthetic Drugs
Thoralf Niendorf, Yiyi Ji, and Sonia Waiczies
OTHER BIOMEDICAL APPLICATIONS
Imaging of the Respiratory System
Marcus J. Couch, Alexei V. Ouriadov, and Mitchell S. Albert
Tracking of Capsules and Catheters in the Human Gastrointestinal Tract
Andreas Steingötter and Tobias Hahn
Perfluorocarbon Theranostic Nanomedicines: Pharmaceutical Scientist’s Perspective
Jelena M. Janjic and Sravan K. Patel
Ulrich Flögel is professor of experimental cardiovascular imaging at the Heinrich Heine University of Düsseldorf, Germany. His research focuses on the interplay of function, energetics, metabolism, and inflammation and its role in the development of cardiovascular diseases using innovative multinuclear MRI/MRS techniques.
Eric Ahrens is professor of radiology and director of Stem Cell Molecular Imaging at the University of California, San Diego. His research focuses on adapting MRI to visualize cellular and molecular events in vivo. His lab is developing novel materials and methods for MRI-based cell tracking that are used for monitoring cell therapies and cellular immunological processes.
"Since the first published images in the mid 1970s, 19F MRI has made a significant comeback in molecular and cellular imaging during the last 10 years. This book is written by an international gathering of scientists who have been expert witnesses to this renaissance, covering every aspect from physical, chemical, and biological perspectives."
—Dr. Jeff W. M. Bulte, Johns Hopkins University, USA
"Fluorine Magnetic Resonance Imaging provides a splendid overview of how the 19F nucleus can be exploited to interrogate healthy and diseased tissues. Written by recognized experts in MRI pulse sequences, imaging hardware, contrast agent chemistry, pharmacy, and medicine, it covers the whole field from the technique to clinical application. An important and highly recommended book."
—Prof. Gustav J. Strijkers, Academic Medical Center, Amsterdam, the Netherlands
"This is an authoritative and comprehensive book on a very important and emerging topic in the field of MRI and biomedical imaging. The editors have engaged the leaders in 19F MRI and cover all basic and advanced concepts in this field. The book is rich in illustrations and examples, which facilitate comprehension. I have no doubt that it is going to be a valuable resource in helping the next generation of scientists and clinicians to continue the process of advancing 19F MRI and its application in biology and medicine."
—Dr. Zahi A. Fayad, Icahn School of Medicine at Mount Sinai, USA