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Forensic Applications of Gas Chromatography




ISBN 9781466507548
Published June 4, 2013 by CRC Press
186 Pages - 109 B/W Illustrations

 
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Book Description

Several areas of forensic science use the technique of gas chromatography, ranging from fire analysis to the investigation of fraudulent food and perfumes. Covering the essentials of this powerful analytical technique, Forensic Applications of Gas Chromatography explains the theory and shows applications of this knowledge to various realms of forensic science.

Topics include:

  • A brief introduction to gas chromatography and its use in forensic science
  • Various components that make up the gas chromatographic instrumentation
  • The theory of the separation process, along with the chemistry underpinning the process
  • Method development, with a specific example of a separation of eight different compounds using a gas chromatography-flame ionization detector
  • Quality assurance and method validation—with information applicable to many types of analytical testing laboratories
  • Troubleshooting in gas chromatography systems
  • New developments in gas chromatography and advances in columns and detectors

Real examples supplement the text, along with questions in each chapter. The book includes examples of applications of gas chromatography in drugs, toxicology, fire, paint, food, and fragrance. Each application is presented as an individual case study with specific focus on a particular sample preparation technique. This allows each technique to be discussed with respect to its theory, instrumentation, solvent selection, and function, as appropriate. Each case study provides readers with suitable practical information to allow them to perform experiments in their own laboratory either as part of a practical laboratory class or in a research context. The final chapter provides answers to the questions and encourages further study and discussion.

Table of Contents

Introduction to Gas Chromatography
Instrumentation for Gas Chromatography
Choice of Gas
Sample Introduction
Column Oven
GC Columns
Detectors
Basic Principles of Chromatography
Theory of Chromatography
Method Development
Influence of Sample Introduction Method
Influence of the Carrier Gas
Influence of the Column
Influence of Oven Temperature
Influence of the Detector
An Example
Quality Assurance and Method Validation
Quality Assurance
Quality Control
Why Be Quality Assured?
Ways to Ensure Quality of Product or Service
Instrument Qualification
Method Validation
Troubleshooting in Gas Chromatography
Introduction
Baseline Disturbances
Irregular Peak Shapes
Retention Time Shifts
Loss of Separation or Resolution
Loss of Sensitivity
Rapid Column Deterioration
Ghost Peaks
Developments in Gas Chromatography
Developments in Sample Preparation Techniques
Developments in Column Technology
Developments in Instrumentation
Forensic Applications of Gas Chromatography
Drug Analysis
Forensic Toxicology
Forensic Analysis of Fire Debris
Paint Analysis
Food and Fragrance Analysis
Answers to Questions
Glossary
Index


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Author(s)

Biography

Michelle Groves Carlin, MSc, BSc (Hons), MRSC, CChem, studied at Heriot-Watt University in the honors program in color chemistry. She then worked at a dyehouse in the Scottish Borders before embarking on a career in analytical chemistry. After some time spent in a contract research organization in Edinburgh, she continued her education with an MSc in forensic science from Strathclyde University. She carried out a research project in the toxicology department of the Institut de Recherche Criminelle de la Gendarmerie Nationale (IRCGN) in Paris using LC-ESI-MS. She then became the manager of a workplace drug-testing laboratory in the north east of England before taking on a teaching position as lecturer in forensic science at Teesside University, where she spent three years. In 2009, she moved to Northumbria University as a senior lecturer in forensic chemistry, where she carries out research in analytical toxicology.

John R. Dean, DSc, PhD, DIC, MSc, BSc, FRSC, CChem, CSci, Cert. Ed., took his first degree in Chemistry at the University of Manchester Institute of Science and Technology (UMIST), followed by an M.Sc. in Analytical Chemistry and Instrumentation at Loughborough University of Technology and finally a Ph.D. and D.I.C. in Physical Chemistry at Imperial College of Science and Technology, London. He then spent two years as a postdoctoral research fellow at the Food Science Laboratory of the Ministry of Agriculture, Fisheries and Food in Norwich in conjunction with Polytechnic South West in Plymouth. This was followed by a temporary lectureship in Inorganic Chemistry at Huddersfield Polytechnic. In 1988 he was appointed to a lectureship in Inorganic/Analytical Chemistry at Newcastle Polytechnic (now Northumbria University). This was followed by promotion to Senior Lecturer (1990), Reader (1994), Principal Lecturer (1998) and Associate Dean (Research) (2004). In 2004 he was appointed as Professor of Analytical and Environmental Science. Since 2008 he has held dual responsibility as Head of the Graduate School and Research Professor in the Department of Applied Sciences. In 1998 he was awarded a D.Sc. (London) in Analytical and Environmental Science and was the recipient of the 23rd SAC Silver Medal in 1995. He has published extensively in analytical and environmental science.

Reviews

" … useful for undergraduate and postgraduate students and young scientists, but also for experienced scientists starting to work with gas chromatography."
Analytical and Bioanalytical Chemistry

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