1st Edition

Free Radicals in Brain Pathophysiology

By Giuseppe Poli Copyright 2000

    This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms.
    Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity!
    With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology

  • focuses on important biological signaling molecules such as superoxide anion and nitric oxide
  • evaluates the action of low levels of oxygen- and nitrogen-centered radicals on cell membranes and receptors to modulate signal transduction pathways and gene expression
  • links high mitochondrial density in neural tissue to brain disease
  • considers how prions and -amyloid proteins influence the level of free radicals within cells
  • assesses the abnormalities of superoxide dismutase in the familial form of amyotrophic lateral sclerosis
  • highlights the occurrence of oxidative stress and the impact of oxidative injury in brain physiology and neurodegeneration
  • and more!
    With contributions from nearly 70 internationally recognized researchers, physiologists, and clinicians who describe their latest findings and provide new insights into the factors underlying neurological disorders, Free Radicals in Brain Pathophysiology is an unsurpassed reference for nutritionists and dietitians, clinical neurologists, pathologists, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.
  • Free Radicals and Antioxidants in Brain Pathophysiology

    The Role of Free Radicals in the Brain in Health and Disease in Relation to Synaptic Plasticity
    John Smythies
    Neuromodulatory Effects of Nitric Oxide in Pain Perception
    Adalberto Merighi, Patrizia Aimar, Laura Lossi, Lucia Pasti, and Giorgio Carmignoto
    Ischemic and Metabolic Stress-Induced Apoptosis
    James David Adams, Jr., Lawrence R. Williams, Suman K. Mukherjee, Lori Klaidman, Glen Inouye, Vierka Cummins, and Maria Morales
    Nitrogen Radicals in Ischemic Damage of the Brain
    Tomris Özben
    Neuroinflammatory Events and Enhanced Signal Transduction Processes Involved in Neurodegeneration
    Robert A. Floyd, C. A. Stewart, K. A. Robinson, G. Bing, and K. Hensley

    Free Radicals in Glutaate and Catecholamine-Mediated Neurotoxicity

    Oxidative Stress in Glutamate Neurotoxicity
    Derick S. Han, Enrique Cadenas, Michael S. Kobayashi, and Lester Packer
    Modulation of Glutamate Release and Toxicity by Nitric Oxide
    C. M. Carvalho, S. M. Sequeira, C. B. Duarte, and Ansélio P. Carvalho
    Interplay Between Oxidative Stress and Calcium Homeostasis in Acute Neuronal Damage and Neurodegenerative Disease
    Julie K. Andersen and Veena Viswanath
    MAO Knockout Mice and Behavior
    Jean Chen Shih, K. Chen, and M. J. Ridd
    DNA Strand Breakage Induced by Nitric Oxide Together with Catecholamine: Implications for Neurodegenerative Diseases
    Hiroshi Ohshima, Yumiko Yoshie, and Isabelle Gilibert
    6-Hydroxydopamine, Dopamine, and Ferritin: A Cycle of Reactions Sustaining Parkinson's Disease?
    G. N. L. Jameson and Wolfgang Linert

    Free Radicals and Antioxidants in Neurological Disorders

    ROS and Parkinson's Disease: A View to a Kill
    Serge Przedborski and Vernice R. Jackson-Lewis
    Nitric Oxide Overproduction and Oxidative Stress in Human Idiopathic Parkinson's Disease
    Emilia Mabel Gatto, Natalia Andrea Riobó, Maria Cecilia Carreras, and Juan José Poderoso


    Giuseppe Poli

    "…up-to-date and comprehensive….an excellent reference for clinicians and scientists in the field of neuroscience.
    "-Saudi Medical Journal