Free Radicals in Brain Pathophysiology: 1st Edition (Hardback) book cover

Free Radicals in Brain Pathophysiology

1st Edition

By Giuseppe Poli

CRC Press

608 pages

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Hardback: 9780824703172
pub: 2000-02-25
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This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms.

Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity!

With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology

  • focuses on important biological signaling molecules such as superoxide anion and nitric oxide

  • evaluates the action of low levels of oxygen- and nitrogen-centered radicals on cell membranes and receptors to modulate signal transduction pathways and gene expression

  • links high mitochondrial density in neural tissue to brain disease

  • considers how prions and -amyloid proteins influence the level of free radicals within cells

  • assesses the abnormalities of superoxide dismutase in the familial form of amyotrophic lateral sclerosis

  • highlights the occurrence of oxidative stress and the impact of oxidative injury in brain physiology and neurodegeneration

  • and more!

    With contributions from nearly 70 internationally recognized researchers, physiologists, and clinicians who describe their latest findings and provide new insights into the factors underlying neurological disorders, Free Radicals in Brain Pathophysiology is an unsurpassed reference for nutritionists and dietitians, clinical neurologists, pathologists, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.

  • Reviews

    "…up-to-date and comprehensive….an excellent reference for clinicians and scientists in the field of neuroscience.

    "-Saudi Medical Journal

    Table of Contents

    Free Radicals and Antioxidants in Brain Pathophysiology

    The Role of Free Radicals in the Brain in Health and Disease in Relation to Synaptic Plasticity

    John Smythies

    Neuromodulatory Effects of Nitric Oxide in Pain Perception

    Adalberto Merighi, Patrizia Aimar, Laura Lossi, Lucia Pasti, and Giorgio Carmignoto

    Ischemic and Metabolic Stress-Induced Apoptosis

    James David Adams, Jr., Lawrence R. Williams, Suman K. Mukherjee, Lori Klaidman, Glen Inouye, Vierka Cummins, and Maria Morales

    Nitrogen Radicals in Ischemic Damage of the Brain

    Tomris Özben

    Neuroinflammatory Events and Enhanced Signal Transduction Processes Involved in Neurodegeneration

    Robert A. Floyd, C. A. Stewart, K. A. Robinson, G. Bing, and K. Hensley

    Free Radicals in Glutaate and Catecholamine-Mediated Neurotoxicity

    Oxidative Stress in Glutamate Neurotoxicity

    Derick S. Han, Enrique Cadenas, Michael S. Kobayashi, and Lester Packer

    Modulation of Glutamate Release and Toxicity by Nitric Oxide

    C. M. Carvalho, S. M. Sequeira, C. B. Duarte, and Ansélio P. Carvalho

    Interplay Between Oxidative Stress and Calcium Homeostasis in Acute Neuronal Damage and Neurodegenerative Disease

    Julie K. Andersen and Veena Viswanath

    MAO Knockout Mice and Behavior

    Jean Chen Shih, K. Chen, and M. J. Ridd

    DNA Strand Breakage Induced by Nitric Oxide Together with Catecholamine: Implications for Neurodegenerative Diseases

    Hiroshi Ohshima, Yumiko Yoshie, and Isabelle Gilibert

    6-Hydroxydopamine, Dopamine, and Ferritin: A Cycle of Reactions Sustaining Parkinson's Disease?

    G. N. L. Jameson and Wolfgang Linert

    Free Radicals and Antioxidants in Neurological Disorders

    ROS and Parkinson's Disease: A View to a Kill

    Serge Przedborski and Vernice R. Jackson-Lewis

    Nitric Oxide Overproduction and Oxidative Stress in Human Idiopathic Parkinson's Disease

    Emilia Mabel Gatto, Natalia Andrea Riobó, Maria Cecilia Carreras, and Juan José Poderoso

    Molecular and Cellular Aspects of Oxidative Damage in Alzheimer's Disease

    Mark A. Smith and George Perry

    Free Radical-Mediated Disruption of Cellular Ion Homeostasis, Mitochondrial Dysfunction, and Neuronal Degeneration in Sporadic and Inherited Alzheimer's Disease

    Mark P. Mattson

    Role of Transgenic Models for the Study of Oxidative Neurotoxicity in Alzheimer's Disease

    Miguel A. Pappolla, Y.-J. Chyan, George Perry, Mark A. Smith, Melissa Sos, and Felix Cruz-Sanchez

    Oxidative Protein Modification in Rosenthal Fibers: Implications for Alexander's Disease Pathogenesis

    Rudolph J. Castellani, George Perry, and Mark A. Smith

    Superoxide Dismutase and Amyotrophic Lateral Sclerosis

    Giuseppe Rotilio, Alberto Ferri, Roberta Gabbianelli, and Maria Teresa Carrì Neurodegeneration and Antioxidant-Based Therapeutic Approaches

    Effects of Ginko Biloba Extract (Egb 761) on Alzheimer's Disease

    Yves Christen, Marie-Thérèse Droy-LeFaix, Catherine Pasquier, and Lester Packer

    Glutathione and Metallothionein in Oxidative Stress of Parkinson's Disease

    Manuchair Ebadi and Midori Hiramatsu

    Estrogens and Other Antioxidants in Neuroprotection: Implications for Alzheimer's Disease

    Christian Behl and Bernd Moosmann

    Therapeutic Potential of Radical Scavengers in Parkinson's Disease

    Silvia Mandel, Edna Grünblatt, and M. B. H. Youdim

    Vitamin E and Other Antioxidant Treatments for the Neurobehavioral Aspects of Alzheimer's Disease and Other Neurodegenerative Disorders

    Fadi Massoud, Mario Schittini, and Mary Sano

    Nitric Oxide and the NMDA Receptor in Ischemia and Reperfusion Injury: Is NO Protective or Injurious?

    Michael Graham Espey, Katrina M. Miranda, Carol A. Colton, Ryszard M. Pluta, Sandra J. Hewett, and David A. Wink

    Endogenous Protection of Retinal Photoreceptors Against Light-Induced Oxidative Stress

    Pier Lorenzo Marchiafava and Biancamaria Longoni

    About the Author/Editors

    Poli\, Giuseppe

    About the Series

    Oxidative Stress and Disease

    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Neurology
    SCIENCE / Chemistry / General
    SCIENCE / Life Sciences / General