Genomics : Fundamentals and Applications book cover
1st Edition

Fundamentals and Applications

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ISBN 9781420067057
Published October 9, 2008 by CRC Press
432 Pages 8 Color & 63 B/W Illustrations

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Book Description

This unique new text delivers a solid foundation for understanding the role of genomics in human health and in advances that promise to help improve the quality of human life. Unlike other works that focus mainly on toxicogenomic techniques, Genomics presents a thorough overview of the field in four major sections: 1) fundamentals of genes and genome structure, function, expression, variations, and genomic technology platforms; 2) applications of genomics in drug discovery and drug development, safety evaluation, genomic database maintenance, mining, and analysis, food safety monitoring, and translational toxicogenomics; 3) how regulatory agencies such as the FDA and EPA use genomic data in their safety evaluation; and 4) a summary of the current state and the future prospect of the science of genomics.

With an international perspective and practical case studies, Genomics is the first resource to present essential discussion of theory and application for:

  • eukaryotic genomes
  • epigenomics
  • translational genomics and biomarker development

Table of Contents

Fundamentals of Eukaryotic Gene Structure and Function. Genomes - A Brief Eukaryotic Perspective. Epigenomes - Beyond Genes and Genomes. Principles of Functional Genomic Analysis. Collaborations Lay the Critical Path. Functional Genomic Approaches. Immunotoxicogenomics. Human Genomics in Hypertension. Translational Toxicogenomics. Mining of Genome Sequence Databases. Microbial Genomics. Features and Functionality of Public Databases. Toxicogenomics in Non-Clinical Safety Studies. Strategies for Quality Assurance. Genomics and Drug Discovery. Physiological Genomic Approaches. Nutrigenomic Approaches. Use of Pharmacogenomic Data. US EPA. Review and Summary.

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SUPRATIM CHOUDHURI is a toxicologist in the Division of Biotechnology and GRAS notice review, Office of Food Additive Safety, U.S. Food and Drug Administration (FDA), College Park, Maryland, USA, and Adjunct Associate Professor at the Department of Pharmacology and Toxicology, University of Kansas Medical Center, Kansas City, KS. Dr. Choudhuri received his Ph.D. and M.Sc. both from the University of Calcutta, Calcutta, India. Dr. Choudhuri is a member of several professional organizations, including a full member of the U.S. Society of Toxicology. Dr. Choudhuri has been a guest reviewer of a number of toxicology and biochemistry journals, and has taught and trained undergraduate and graduate students, and postdoctoral researchers. Dr. Choudhuri has extensively published in the fields of molecular toxicology, genomics and metabolism; his teaching, research, and regulatory expertise includes molecular mechanisms of toxicity, toxicogenomics, comparative toxicology, metabolism and transporters, and regulatory safety assessment. Dr. Choudhuri has been invited to speak and chair sessions at various national and international meetings, and he is the recipient of numerous FDA awards.

DAVID B. CARLSON is a toxicologist in the Division of Metabolism and Endocrinology Products, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, Maryland, and an Adjunct Assistant Professor of Biotechnology, University of Maryland University College, Adelphi, MD. Dr. Carlson received a B.S. from Duke University and a Ph.D. from Oregon State University. Dr. Carlson is an active member of several professional organizations, including the Society of Toxicology and the Society of Environmental Toxicology and Chemistry. Dr. Carlson has extensive publication and peer-review experience in scholarly journals and he has been invited to speak at national and international professional meetings in his area of expertise. Dr. Carlson’s teaching, research, and regulatory expertise includes mechanisms of endocrine disruption and nuclear receptor signaling, comparative toxicology and carcinogenesis, and safety assessment of drugs and food additives. Dr. Carlson is the recipient of numerous academic and FDA scholarships and awards.