Full-field optical coherence microscopy (FF-OCM) is an imaging technique that provides cross-sectional views of the subsurface microstructure of semitransparent objects. The technology is based on low-coherence interference microscopy, which uses an area camera for en face imaging of the full-field illuminated object. FF-OCM benefits from the lateral imaging resolution of optical microscopy along with the capacity of optical axial sectioning at micrometer-scale resolution. The technique can be employed in diverse applications, in particular for non-invasive examination of biological tissues.
This handbook is the first to be entirely devoted to FF-OCM. It is organized into four parts with a total of 21 chapters written by recognized experts and major contributors to the field. After a general introduction to FF-OCM, the fundamental characteristics of the technology are analyzed and discussed theoretically. The main technological developments of FF-OCM for improving the image acquisition speed and for endoscopic imaging are presented in part II. Extensions of FF-OCM for image contrast enhancement or functional imaging are reported in part III. The last part of the book provides an overview of possible applications of FF-OCM in medicine, biology, and materials science.
A comprehensive compilation of self-contained chapters written by leading experts, this handbook is a definitive guide to the theoretical analyses, technological developments, and applications of FF-OCM. Using the rich information the book is replete with, a wide range of readers, from scientists and physicists to engineers as well as clinicians and biomedical researchers, can get a handle on the latest major advances in FF-OCM.
Table of Contents
Introduction to Full-Field Optical Coherence Microscopy. Theory of Imaging and Coherence Effects in Full-Field Optical Coherence Microscopy. Spatiotemporal Coherence Effects in Full-Field Optical Coherence Tomography. Cross Talk in Full-Field Optical Coherence Tomography. Signal Processing Methods in Full-Field Optical Coherence Microscopy. High-Speed Image Acquisition Techniques of Full-Field Optical Coherence Tomography. Toward Single-Shot Imaging in Full-Field Optical Coherence Tomography. Frequency Domain Full-Field Optical Coherence Tomography. Full-Field OCM for Endoscopy. Full-Field Optical Coherence Tomography and Microscopy Using Spatially Incoherent Monochromatic Light. Real-Time and High-Quality Online 4D FF-OCT Using Continuous Fringe Scanning with a High-Speed Camera and FPGA Image Processing. Digital Interference Holography for Tomographic Imaging. Technological Extensions of Full-Field Optical Coherence Microscopy for Multicontrast Imaging. Spectroscopic Full-Field Optical Coherence Tomography. Multiwavelength Full-Field Optical Coherence Tomography. Dual-Modality Full-Field Optical Coherence and Fluorescence Sectioning Microscopy: Toward All Optical Digital Pathology on Freshly Excised Tissue. Full-Field Optical Coherence Tomography for Rapid Histological Evaluation of ex vivo Tissues. FF-OCT Imaging: A Tool for Human Breast and Brain Tissue Characterization. Full-Field Optical Coherence Microscopy in Ophthalmology. Investigation of Spindle Structure and Embryo Development for Preimplantation Genetic Diagnosis by Subcellular Live Imaging with FF-OCT. FF-OCT for Nondestructive Material Characterization and Evaluation.
Arnaud Dubois is a professor at Institut d’Optique Graduate School in Palaiseau, France. He received his PhD from Paris-Saclay University in 1997. His current research interests concern biophotonics and optical imaging. A pioneer in full-field optical coherence microscopy in the early 2000s, Prof. Dubois has since been a major contributor to the development of this technology. In 2014 he co-founded DAMAE Medical, a company working on an innovative optical coherence microscopy technique for in situ diagnosis of skin diseases. He is the author or coauthor of more than 100 research articles and 12 book chapters. He has participated in about 200 conferences and has 5 patents to his credit. His teaching activities cover most aspects of optics at the master’s level.