1170 Pages 51 Color & 188 B/W Illustrations
    by Jenny Stanford Publishing

    1170 Pages 51 Color & 188 B/W Illustrations
    by Jenny Stanford Publishing

    Low-Level Laser Therapy (LLLT) also known as photobiomodulation is almost 50 years old, and recently has been getting increasing acceptance from the scientific, medical, and veterinary communities. Discoveries are constantly being made about the cellular and molecular mechanisms of action, the range of diseases that can be treated is also rising, and home use LED devices are becoming common.

    This book compiles cutting-edge contributions from the world’s leading experts in Photobiomodulation and LLLT. Chapters cover general concepts, mechanisms of action, in vitro studies, pre-clinical animal studies, veterinary applications and a wide range of clinical topics. Edited by Michael Hamblin from Massachusetts General Hospital and Harvard Medical School, aided by two prominent researchers (Marcelo Sousa and Tanupriya Agrawal), this book will appeal to anyone involved in the basic science, translational aspects and clinical applications of LLLT.

    What is Low-Level Laser (Light) Therapy?

    Marcelo Victor Pires de Sousa

    History of Low-Level Laser (Light) Therapy

    Michael R. Hamblin

    Lasers, LEDs, and Other Light Sources

    James Carroll

    Is Coherence Important in Photobiomodulation?

    Tomas Hode

    Tissue Optics

    Bryan James Stephens and Linda Ramball Jones

    Light–Tissue Interaction and Light Dosimetry

    Ana Carolina de Magalhaes and Elisabeth Mateus Yoshimura

    Mitochondrial Light Absorption and Its Effect on ATP Production

    Nicolette Houreld

    Water as a Photoacceptor, Energy Transducer, and Rechargeable Electrolytic Bio-battery in Photobiomodulation

    Luis Santana-Blank, Elizabeth Rodr´ıguez-Santana, Jes ´us A. Santana-Rodr´ıguez, Karin E. Santana-Rodriguez, and Heberto Reyes-Barrios

    Role of Reactive Oxygen Species in Low-Level Laser Therapy

    Vikrant Rai

    Molecular Basis for Photobiomodulation: Light-Induced Nitric Oxide Synthesis by Cytochrome c Oxidase in Low-Level Laser Therapy

    Robert Oliver Poyton and Marina Hendrickson

    Cytoprotective Effect of Low-Level Light Therapy using LEDs on Neurons

    Margaret Wong-Riley and Huan Ling Liang

    Low-Level Laser and Cultured Neural Tissue

    Patricia J. Armati and Roberta T. Chow

    Shining a Light on Parkinson’s Disease

    Daniel McKenzie Johnstone, Cecile Moro, Jonathan Stone, Alim-Louis Benabid, and John Mitrofanis

    Low-Level Laser Therapy and Stem Cells

    Qi Zhang, Chang Zhou, and Tingting Dong

    Antimicrobial Photodynamic Therapy

    Vanderlei Salvador Bagnato, Cristina Kurachi, Kate Cristina Blanco, and Natalia Mayumi Inada

    Low-Level Laser (Light) Therapy forWound Healing in Animal Models

    Andre Luiz Oliveira Ramos, Felipe Scholz Ramos, and Marcelo Victor Pires de Sousa

    Low-Level Laser Therapy for Arthritis in Animal Models: Beneficial Effect and Action Mechanism

    Flavio Aimbire and Paulo de Tarso Camilo de Carvalho

    Low-Level Laser Therapy for Lung Diseases: From the Bench to the Bed

    Flavio Aimbire

    Low-Level Laser (Light) Therapy in Tendon Healing in in Vitro and in Vivo Models

    Lucas F. de Freitas and Michael R. Hamblin

    Bone Repair in Animal Models

    Antonio Luiz B. Pinheiro, Luiz G. Pinheiro Soares, and Aparecida Maria C. Marques

    Transcranial Low-Level Laser (Light) Therapy for Stroke and Traumatic Brain Injury in Animal Models

    Michael R. Hamblin, Luis De Taboada, and Ying-Ying Huang

    Phototherapy in Peripheral Nerve Repair and Muscle Preservation

    Shimon Rochkind

    Low-Level Laser Therapy for Spinal Cord Repair

    Takahiro Ando and Michael R. Hamblin

    Low-Level Laser (Light) Therapy for the Treatment of Visual System Injury and Disease

    Janis T. Eells, Sandeep Gopalakrishnan, Michele M. Salzman, Krisztina Valter, Jan Provis, Ricardo Natoli, John Mitrofanis, Jonathan Stone, and Melinda Fitzgerald

    Protection from Cardiac Ischemia and Reperfusion Injury

    Agnes Keszler, Svjetlana Dosenovic, and Martin Bienengraeber

    Low-Level Laser and Experimental Aortic Aneurysm: Mechanisms and Therapeutic Implications

    Lilach Gavish and S. David Gertz

    Low-Level Laser Therapy: A Treatment Modality for Multiple Sclerosis Targeting Autoimmunity and Oxidative Stress

    Zenas George, Miguel A. Tolentino, and Jeri-Anne Lyons

    Low-Level Laser Therapy as an Alternative Treatment for Snake Envenomation

    Camila Squarzoni Dale and Stella Regina Zamuner

    Veterinary Low-Level Laser (Light) Therapy Applications for Companion Animals

    Richard L. Godine

    Emergence of Low-Level Laser (Light) Therapy in Clinical Veterinary Practice

    Ronald E. Hirschberg

    Photomedicine for Exotic Animals: A Case-Based Discussion

    Narda G. Robinson

    Recalcitrant Wound: Using Low-Level Laser (Light) Therapy to Manage Non-Healing Wounds and Ulcers

    Raymond J. Lanzafame and Istvan Stadler

    Clinical Applications with Low-Level Laser Therapy in Arthritis

    Jan M. Bjordal

    Use of Low-Level Laser Therapy and Light-Emitting Diode Therapy to Improve Muscle Performance and Prevent Damage: From Animal Models to Clinical Trials

    Cleber Ferraresi, Nivaldo Parizotto, Vanderlei Bagnato, and Michael R. Hamblin

    Low-Level Laser Therapy of Pain: Clinical Applications

    Roberta T. Chow

    Low-Level Laser Therapy and Its Application in Tinnitus

    Alessandra Nara de Souza Rastelli, Emanuelle Teixeira Carrera, Gustavo Nicolodelli, and Michael R. Hamblin

    Laser Therapy for the Treatment of Radiculopathy

    Jerome M. True and Luis C. Vera

    Difficult Path to Treating Acute Ischemic Stroke Patients with Transcranial Near-Infrared Laser Therapy

    Paul A. Lapchak, Pramod Butte, and Padmesh S. Rajput

    Low-Level Laser (Light) Therapy for Rehabilitation in Traumatic Brain Injury and Stroke, including Chronic Aphasia

    Margaret A. Naeser, Paula I. Martin, Michael D. Ho, Maxine H. Krengel, Yelena Bogdanova, Jeffrey A. Knight, Megan K. Yee, Ross Zafonte, Bang-Bon Koo, John G. Roubil, and Michael R. Hamblin

    Transcranial Near-Infrared Light for Major Depressive Disorder: Targeting the Brain Metabolism

    Paolo Cassano, Abigail R. Archibald, and Dan V. Iosifescu

    Low-Level Laser Therapy: A Corner Stone in the Management of Cancer Therapy–Induced Mucositis

    Rene-Jean Bensadoun, Idriss Troussier, and Raj G. Nair

    Photobiomodulation in Dentistry: Manipulating Biostimulation and Bioinhibition for Clinical Success

    Gerry Ross and Alana Ross

    Photobiomodulation for the Clinical Treatment of Age-Related Macular Degeneration

    Graham Merry and Robert Dotson

    Laser (Light) Therapy for Postherpetic Neuralgia

    Kevin C. Moore and R. Glen Calderhead

    Laser Acupuncture

    Lucas F. de Freitas and Michael R. Hamblin

    Intravascular Laser Irradiation of Blood

    Daiane Thais Meneguzzo, Leila Soares Ferreira, Eduardo Machado de Carvalho, and Cassia Fukuda Nakashima

    Nonsurgical Laser Therapy for Type 1 and Type 2 Diabetes

    Leonardo Longo

    Laser Therapy of Traumatic Central Nervous System Injuries

    Leonardo Longo and Diego Longo

    Low-Level Laser (Light) Therapy: Aesthetic Applications for Hair

    Felipe Scholz Ramos, Andr´e Luiz de Oliveira Ramos, and Marcelo Victor Pires de Sousa

    Low-Level Laser (Light) Therapy for Cosmetics and Dermatology

    Mossum K. Sawhney and Michael R. Hamblin

    Low-Level Laser Therapy for Body Contouring and Fat Reduction

    Gaurav K. Gupta

    Transcranial Low-Level Laser (Light) Therapy for Neurocognitive Enhancement

    Julio C. Rojas and F. Gonzalez-Lima

    Post-Operative Uses of Low-Level Laser Therapy

    Maria Cristina Chavantes, Nathali Cordeiro Pinto, and Vanessa Milanesi Holanda

    Bright New World: Future Directions of Low-Level Laser (Light) Therapy

    Marcelo Victor Pires de Sousa and Maria Cristina Chavantes


    Michael R. Hamblin is a principal investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, Boston, and an associate professor of dermatology at Harvard Medical School and the Harvard-MIT Division of Health Science and Technology. His research interests lie in the areas of photodynamic therapy and low-level light therapy. He has published over 284 peer-reviewed articles and is a fellow of the SPIE.

    Marcelo Victor Pires de Sousa holds a bachelor’s degree and a PhD in physics. He is founder and chief science officer of Bright Photomedicine and is involved in the development of new products and dissemination of photomedicine.

    Tanupriya Agrawal obtained her MD in 2006 from Netaji Subhash Chandra Bose Government Medical College, Jabalpur, India, followed by a PhD in biomedical sciences from Creighton University, Omaha, Nebraska. She is a visiting postdoctoral fellow at Dr. Hamblin’s lab at the Wellman Center for Photomedicine, Massachusetts General Hospital. She is also an trainee pathology resident at Tufts Medical Center, Boston. Dr. Agrawal has published 11 peer-reviewed articles and 12 conference proceedings, including one oral presentation.

    "The book presents exhaustive and timely coverage of low-power laser light therapy and photobiomodulation, a subject gaining increasing acceptance from the scientific and medical communities after years of controversial interpretations of clinical results. The editors have well-coordinated the fifty-four chapters written by experts from universities and hospitals. The book offers a panorama of the many applications reported so far, each of which is referenced within a vast bibliography."

    — Optics & Photonics News