Handbook of Low-Level Laser Therapy  book cover
1st Edition

Handbook of Low-Level Laser Therapy

ISBN 9789814669603
Published August 4, 2021 by Jenny Stanford Publishing
1170 Pages 51 Color & 188 B/W Illustrations

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USD $520.00

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Book Description

Low-Level Laser Therapy (LLLT) also known as photobiomodulation is almost 50 years old, and recently has been getting increasing acceptance from the scientific, medical, and veterinary communities. Discoveries are constantly being made about the cellular and molecular mechanisms of action, the range of diseases that can be treated is also rising, and home use LED devices are becoming common.

This book compiles cutting-edge contributions from the world’s leading experts in Photobiomodulation and LLLT. Chapters cover general concepts, mechanisms of action, in vitro studies, pre-clinical animal studies, veterinary applications and a wide range of clinical topics. Edited by Michael Hamblin from Massachusetts General Hospital and Harvard Medical School, aided by two prominent researchers (Marcelo Sousa and Tanupriya Agrawal), this book will appeal to anyone involved in the basic science, translational aspects and clinical applications of LLLT.

Table of Contents

What is Low-Level Laser (Light) Therapy?

Marcelo Victor Pires de Sousa

History of Low-Level Laser (Light) Therapy

Michael R. Hamblin

Lasers, LEDs, and Other Light Sources

James Carroll

Is Coherence Important in Photobiomodulation?

Tomas Hode

Tissue Optics

Bryan James Stephens and Linda Ramball Jones

Light–Tissue Interaction and Light Dosimetry

Ana Carolina de Magalhaes and Elisabeth Mateus Yoshimura

Mitochondrial Light Absorption and Its Effect on ATP Production

Nicolette Houreld

Water as a Photoacceptor, Energy Transducer, and Rechargeable Electrolytic Bio-battery in Photobiomodulation

Luis Santana-Blank, Elizabeth Rodr´ıguez-Santana, Jes ´us A. Santana-Rodr´ıguez, Karin E. Santana-Rodriguez, and Heberto Reyes-Barrios

Role of Reactive Oxygen Species in Low-Level Laser Therapy

Vikrant Rai

Molecular Basis for Photobiomodulation: Light-Induced Nitric Oxide Synthesis by Cytochrome c Oxidase in Low-Level Laser Therapy

Robert Oliver Poyton and Marina Hendrickson

Cytoprotective Effect of Low-Level Light Therapy using LEDs on Neurons

Margaret Wong-Riley and Huan Ling Liang

Low-Level Laser and Cultured Neural Tissue

Patricia J. Armati and Roberta T. Chow

Shining a Light on Parkinson’s Disease

Daniel McKenzie Johnstone, Cecile Moro, Jonathan Stone, Alim-Louis Benabid, and John Mitrofanis

Low-Level Laser Therapy and Stem Cells

Qi Zhang, Chang Zhou, and Tingting Dong

Antimicrobial Photodynamic Therapy

Vanderlei Salvador Bagnato, Cristina Kurachi, Kate Cristina Blanco, and Natalia Mayumi Inada

Low-Level Laser (Light) Therapy forWound Healing in Animal Models

Andre Luiz Oliveira Ramos, Felipe Scholz Ramos, and Marcelo Victor Pires de Sousa

Low-Level Laser Therapy for Arthritis in Animal Models: Beneficial Effect and Action Mechanism

Flavio Aimbire and Paulo de Tarso Camilo de Carvalho

Low-Level Laser Therapy for Lung Diseases: From the Bench to the Bed

Flavio Aimbire

Low-Level Laser (Light) Therapy in Tendon Healing in in Vitro and in Vivo Models

Lucas F. de Freitas and Michael R. Hamblin

Bone Repair in Animal Models

Antonio Luiz B. Pinheiro, Luiz G. Pinheiro Soares, and Aparecida Maria C. Marques

Transcranial Low-Level Laser (Light) Therapy for Stroke and Traumatic Brain Injury in Animal Models

Michael R. Hamblin, Luis De Taboada, and Ying-Ying Huang

Phototherapy in Peripheral Nerve Repair and Muscle Preservation

Shimon Rochkind

Low-Level Laser Therapy for Spinal Cord Repair

Takahiro Ando and Michael R. Hamblin

Low-Level Laser (Light) Therapy for the Treatment of Visual System Injury and Disease

Janis T. Eells, Sandeep Gopalakrishnan, Michele M. Salzman, Krisztina Valter, Jan Provis, Ricardo Natoli, John Mitrofanis, Jonathan Stone, and Melinda Fitzgerald

Protection from Cardiac Ischemia and Reperfusion Injury

Agnes Keszler, Svjetlana Dosenovic, and Martin Bienengraeber

Low-Level Laser and Experimental Aortic Aneurysm: Mechanisms and Therapeutic Implications

Lilach Gavish and S. David Gertz

Low-Level Laser Therapy: A Treatment Modality for Multiple Sclerosis Targeting Autoimmunity and Oxidative Stress

Zenas George, Miguel A. Tolentino, and Jeri-Anne Lyons

Low-Level Laser Therapy as an Alternative Treatment for Snake Envenomation

Camila Squarzoni Dale and Stella Regina Zamuner

Veterinary Low-Level Laser (Light) Therapy Applications for Companion Animals

Richard L. Godine

Emergence of Low-Level Laser (Light) Therapy in Clinical Veterinary Practice

Ronald E. Hirschberg

Photomedicine for Exotic Animals: A Case-Based Discussion

Narda G. Robinson

Recalcitrant Wound: Using Low-Level Laser (Light) Therapy to Manage Non-Healing Wounds and Ulcers

Raymond J. Lanzafame and Istvan Stadler

Clinical Applications with Low-Level Laser Therapy in Arthritis

Jan M. Bjordal

Use of Low-Level Laser Therapy and Light-Emitting Diode Therapy to Improve Muscle Performance and Prevent Damage: From Animal Models to Clinical Trials

Cleber Ferraresi, Nivaldo Parizotto, Vanderlei Bagnato, and Michael R. Hamblin

Low-Level Laser Therapy of Pain: Clinical Applications

Roberta T. Chow

Low-Level Laser Therapy and Its Application in Tinnitus

Alessandra Nara de Souza Rastelli, Emanuelle Teixeira Carrera, Gustavo Nicolodelli, and Michael R. Hamblin

Laser Therapy for the Treatment of Radiculopathy

Jerome M. True and Luis C. Vera

Difficult Path to Treating Acute Ischemic Stroke Patients with Transcranial Near-Infrared Laser Therapy

Paul A. Lapchak, Pramod Butte, and Padmesh S. Rajput

Low-Level Laser (Light) Therapy for Rehabilitation in Traumatic Brain Injury and Stroke, including Chronic Aphasia

Margaret A. Naeser, Paula I. Martin, Michael D. Ho, Maxine H. Krengel, Yelena Bogdanova, Jeffrey A. Knight, Megan K. Yee, Ross Zafonte, Bang-Bon Koo, John G. Roubil, and Michael R. Hamblin

Transcranial Near-Infrared Light for Major Depressive Disorder: Targeting the Brain Metabolism

Paolo Cassano, Abigail R. Archibald, and Dan V. Iosifescu

Low-Level Laser Therapy: A Corner Stone in the Management of Cancer Therapy–Induced Mucositis

Rene-Jean Bensadoun, Idriss Troussier, and Raj G. Nair

Photobiomodulation in Dentistry: Manipulating Biostimulation and Bioinhibition for Clinical Success

Gerry Ross and Alana Ross

Photobiomodulation for the Clinical Treatment of Age-Related Macular Degeneration

Graham Merry and Robert Dotson

Laser (Light) Therapy for Postherpetic Neuralgia

Kevin C. Moore and R. Glen Calderhead

Laser Acupuncture

Lucas F. de Freitas and Michael R. Hamblin

Intravascular Laser Irradiation of Blood

Daiane Thais Meneguzzo, Leila Soares Ferreira, Eduardo Machado de Carvalho, and Cassia Fukuda Nakashima

Nonsurgical Laser Therapy for Type 1 and Type 2 Diabetes

Leonardo Longo

Laser Therapy of Traumatic Central Nervous System Injuries

Leonardo Longo and Diego Longo

Low-Level Laser (Light) Therapy: Aesthetic Applications for Hair

Felipe Scholz Ramos, Andr´e Luiz de Oliveira Ramos, and Marcelo Victor Pires de Sousa

Low-Level Laser (Light) Therapy for Cosmetics and Dermatology

Mossum K. Sawhney and Michael R. Hamblin

Low-Level Laser Therapy for Body Contouring and Fat Reduction

Gaurav K. Gupta

Transcranial Low-Level Laser (Light) Therapy for Neurocognitive Enhancement

Julio C. Rojas and F. Gonzalez-Lima

Post-Operative Uses of Low-Level Laser Therapy

Maria Cristina Chavantes, Nathali Cordeiro Pinto, and Vanessa Milanesi Holanda

Bright New World: Future Directions of Low-Level Laser (Light) Therapy

Marcelo Victor Pires de Sousa and Maria Cristina Chavantes

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Michael R. Hamblin is a principal investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, Boston, and an associate professor of dermatology at Harvard Medical School and the Harvard-MIT Division of Health Science and Technology. His research interests lie in the areas of photodynamic therapy and low-level light therapy. He has published over 284 peer-reviewed articles and is a fellow of the SPIE.

Marcelo Victor Pires de Sousa holds a bachelor’s degree and a PhD in physics. He is founder and chief science officer of Bright Photomedicine and is involved in the development of new products and dissemination of photomedicine.

Tanupriya Agrawal obtained her MD in 2006 from Netaji Subhash Chandra Bose Government Medical College, Jabalpur, India, followed by a PhD in biomedical sciences from Creighton University, Omaha, Nebraska. She is a visiting postdoctoral fellow at Dr. Hamblin’s lab at the Wellman Center for Photomedicine, Massachusetts General Hospital. She is also an trainee pathology resident at Tufts Medical Center, Boston. Dr. Agrawal has published 11 peer-reviewed articles and 12 conference proceedings, including one oral presentation.


"The book presents exhaustive and timely coverage of low-power laser light therapy and photobiomodulation, a subject gaining increasing acceptance from the scientific and medical communities after years of controversial interpretations of clinical results. The editors have well-coordinated the fifty-four chapters written by experts from universities and hospitals. The book offers a panorama of the many applications reported so far, each of which is referenced within a vast bibliography."

— Optics & Photonics News