2nd Edition

Handbook of Pediatric Epilepsy Case Studies, Second Edition

Edited By Maria Montenegro, Jong M. Rho Copyright 2023
    424 Pages 44 Color & 39 B/W Illustrations
    by CRC Press

    424 Pages 44 Color & 39 B/W Illustrations
    by CRC Press

    Research in the field of epilepsy will continue at a rapid pace, with the ultimate hope of curing many intractable epilepsy syndromes. Fully updated, this new edition is organized chronologically, from neonate through adolescence, and the handbook is the culmination of a group effort involving leading physicians and researchers whose contributions constitute a concise and practical reference for health professionals in training. Here the contributors review the recent flood of new information on the pathophysiology, genetics, and treatment of the various epilepsy syndromes, and the volume is distilled into an easy-to-use guide.

    • Fully updated text reviewing the latest research on the pathophysiology, genetics, and treatment of the various epilepsy syndromes.
    • Thorough descriptions of the different syndromes commonly encountered in clinical practice across the pediatric range.
    • Extensive resource section provided.
    • Contributors describe why they chose each particular case, what they learned, and how it changed their practice.
    • The book includes the most recent classification and nomenclature published by the International League Against Epilepsy. 

    Section I: The Basics

    Chapter 1

    A Pediatric Epilepsy Primer

    James W. Owens, MD, PhD

    Chapter 2

    Epilepsy Genetics Primer

    Kimberly Wiltrout, MD and Annapurna Poduri, MD, MPH

    Chapter 3

    Developmental Pharmacokinetics: Principles and Practice

    Melissa Barker-Haliski, PhD

    Chapter 4

    Dietary Therapies for Epilepsy

    Eric H. Kossoff, MD

    Chapter 5

    Vagus Nerve Stimulation Therapy

    James W. Wheless, MD, Nitish Chourasia, M.D and Andrew J. Gienapp, B.A.

    Chapter 6

    Neuromodulation Devices: Responsive Neurostimulation and Deep Brain Stimulation

    Shifteh S. Sattar, MD

    Chapter 7

    Epilepsy Surgery in Children

    Ann Hyslop, MD

    Chapter 8

    Status Epilepticus

    Sonali Sen, MD and James J. Riviello, Jr, MD

    Chapter 9

    Focal Cortical Dysplasia

    Harvey B. Sarnat, MD, MS, FRCPC

    Chapter 10

    Malformations of Cortical Development

    Marilisa M. Guerreiro, MD, PhD and Maria Augusta Montenegro, MD, PhD

    Section II: The Neonate

    Chapter 11

    Self-Limited Neonatal Epilepsy Syndromes

    Maria Augusta Montenegro, MD, PhD

    Chapter 12

    Self-Limited (Familial) Infantile Epilepsy

    Heather Pekeles, MD and Kenneth A. Myers, MD PhD

    Chapter 13

    Early Myoclonic Encephalopathy (Ohtahara Syndrome)

    Reega Purohit, MD and Linda Laux, MD

    Chapter 14

    Early Myoclonic Encephalopathy

    Juan Ignacio Appendino, MD and Juan Pablo Appendino, MD

    Chapter 15

    Hypoxic-Ischemic Encephalopathy (Neonatal Seizures)

    Jeffrey J. Gold, MD, PhD

    Chapter 16

    Epilepsy of Infancy with Migrating Focal Seizures

    Daneille DeCampo, MD and Eric Marsh MD, PhD

    Section III: The Infant

    Chapter 17

    Febrile Seizures

    Morris H. Scantlebury, MD

    Chapter 18

    Genetic Epilepsy with Febrile Seizures Plus (GEFS+)

    Michaela Castello, MD, PhD and Aliya Frederick, MD, PhD

    Chapter 19

    Myoclonic Epilepsy of Infancy

    Douglas R. Nordli, III, MD and Douglas R. Nordli, Jr., MD

    Chapter 20

    Dravet Syndrome

    Douglas R. Nordli, III, MD and Douglas R. Nordli, Jr, MD

    Chapter 21

    Glucose Transporter-1 Deficiency Syndrome

    Joerg Klepper, MD

    Chapter 22

    Infantile Epileptic Spasms Syndrome

    Shaun A. Hussain, MD, MS

    Chapter 23

    Gelastic Seizures

    Samiya Ahmad, MD and Yu-tze Ng, MD, FRACP

    Chapter 24

    Intractable Epilepsy after Herpes Simplex Encephalitis

    Daniel A. Freedman, DO and Dave F. Clarke, MD

    Chapter 25

    Refractory Status Epilepticus

    Sonali Sen, MD and James J. Riviello, Jr, MD

    Chapter 26

    Primary Mitochondrial Epilepsies

    Russell P. Saneto, DO, PhD

    Chapter 27

    Tuberous Sclerosis Complex

    Aimee F. Luat, MD and Harry T. Chugani, MD

    Chapter 28

    Sturge–Weber Syndrome

    Sabrina Tavella-Burka, DO and Ajay Gupta, MD

    Section IV: The Child

    Chapter 29

    Self-Limited Epilepsy with Centrotemporal Spikes (Benign Rolandic Epilepsy)

    Olivia Kim-McManus, MD

    Chapter 30

    Self-Limited Epilepsy with Autonomic Seizures (Panayiotopoulos Syndrome)

    Korwyn Williams, MD, PhD

    Chapter 31

    Childhood Occipital Visual Epilepsy

    Maria Augusta Montenegro, MD, PhD

    Chapter 32

    Photosensitive Occipital Lobe Epilepsy

    Maria Augusta Montenegro, MD, PhD

    Chapter 33

    Childhood Absence Epilepsy

    Stephane Auvin, MD, PhD, FAES

    Chapter 34

    Epilepsy with Myoclonic Absence

    Anita M. Devlin, MBBS, MD

    Chapter 35

    Lennox–Gastaut Syndrome

    Jong M. Rho, MD

    Chapter 36

    Epilepsy with Myoclonic-Atonic Seizures (Doose Syndrome)

    A.G. Christina Bergqvist, MD

    Chapter 37

    Landau–Kleffner Syndrome

    Frank M. C. Besag, FRCP, FRCPsych, FRCPCH

    Chapter 38

    Developmental/Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep (D/EE-SWAS) 

    Kevin Chapman, MD

    Chapter 39

    Epilepsy with Eyelid Myoclonia (Jeavons Syndrome)

    Ifrah Zawar MD and Elia Pestana Knight MD, FAES, FACNS

    Chapter 40

    Anti-NMDA Receptor Encephalitis

    Jennifer Yang, MD and Jennifer Graves, MD, PhD, MAS

    Chapter 41

    Nonconvulsive Status Epilepticus

    Sonali Sen, MD and James J. Riviello, Jr, MD

    Chapter 42

    Febrile Infection-Related Epilepsy Syndrome (FIRES)

    Rima Nabbout, MD, PhD and Sara Matricardi, MD, PhD

    Chapter 43

    New-Onset Refractory Status Epilepticus (NORSE)

    Steven Yang, DO and Jerry Shih, MD

    Chapter 44

    Low-Grade Developmental and Epilepsy Associated Brain Tumors

    Christie Becu, MD and Angus Wilfong, MD

    Chapter 45

    Rasmussen's Encephalitis

    Maria Augusta Montenegro, MD, PhD

    Section V: The Adolescent

    Chapter 46

    Juvenile Myoclonic Epilepsy

    Cornelia Drees, MD

    Chapter 47

    Epilepsy with Generalized Tonic-Clonic Seizures Alone

    Kaitlin C. James and Jesus Eric Pina-Garza, MD

    Chapter 48

    Juvenile Absence Epilepsy

    Maria Augusta Montenegro, MD, PhD

    Chapter 49

    New-Onset Seizure in an Adolescent Female

    Mary L. Zupanc, MD

    Chapter 50

    Temporal Lobe Epilepsy

    June Yoshii-Contreras, MD

    Chapter 51

    Unverricht–Lundborg Disease

    Mayank Verma, MD, PhD, Danielle M. Andrade, MD and Berge A. Minassian, MD, CM, FRCP(C)

    Chapter 52

    Reflex Seizures

    Maria Augusta Montenegro

    Chapter 53

    Sleep-Related Hypermotor Epilepsy

    Kevin Chapman, MD

    Chapter 54

    Psychogenic Nonepileptic Seizures

    Guillermo Delgado-García, MD,MSc and Colin B. Josephson, MD, MSc, MSc, FRCP(C), CSCN (EEG)



    Maria Augusta Montenegro is a pediatric neurologist and epileptologist currently working at Rady Children's Hospital / University of California San Diego School of Medicine. Her clinical expertise is in pediatric epilepsy, with an emphasis on epileptic encephalopathy and EEG. Dr. Montenegro completed medical school, residency, and Ph.D. at the University of Campinas (Brazil) and a post-doctorate research fellowship at Columbia University (NY). Prior to her current position, Dr. Montenegro held an academic faculty appointment at the University of Campinas (Brazil) where she was the head of Pediatric Neurology.  

    Dr. Jong M. Rho is a Professor of Neurosciences, Pediatrics and Pharmacology at the University of California San Diego, and Division Chief of Pediatric Neurology at the Rady Children’s Hospital San Diego. He received a bachelor’s degree in molecular biophysics and biochemistry at Yale University, and a M.D. from the University of Cincinnati. Dr. Rho has held prior faculty appointments at the University of Washington (Seattle), the University of California at Irvine, the Barrow Neurological Institute (Phoenix), and most recently, the University of Calgary. Dr. Rho's main research interests are the mechanisms underlying the anti-seizure and neuroprotective effects of metabolism-based treatments such as the ketogenic diet. His research activities have been sponsored by research grants from the U.S. National Institutes of Health, Canadian Institutes of Health Research, and other public and private sector sources.