536 Pages
by
CRC Press
536 Pages
by
CRC Press
Also available as eBook on:
This book focuses on heat shock response-an active yet transient reprogramming of cellular activities to the needs of a stress protection mechanism designed to minimize heat damage and to optimize restoration of normal cellular activities after the stress period. This work places major emphasis on the structure and possible cellular functions of heat shock proteins as well as the analysis of heat... Read more
INTRODUCTION: HISTORICAL ROOTS. STRESS PROTEINS and GENES. Inducers: Heat Shock and Chemical Stressors. Heat Shock Proteins. HSP-Coding Genes. The Glucose-Regulated Proteins (GRP). RNAs as Heat Shock Products. Gene Technology and Functional Analyses of hs Genes. The Heat Shock Transcription Factor. Control of HSP Synthesis. PROGRAMMING of CELLULAR ACTIVITIES. Chromatin Structure, Transcription and Pre-mRNP Processing. Synthesis and Degradation of Ribosomes. Translational Control. Modification and Degradation of Proteins. Recovery of Gene Expression. Heat Shock-Induced Changes of Cell Ultrastructure. Cell Cycle and DNA Synthesis. Intracellular Localization of Heat Shock Proteins. Induced Thermotolerance. Heat Shock Induced Developmental Effects. Hyperthermia and Virus Multiplication. Hyperthermic Treatment of Cancer.
Biography
Nover\, Lutz
