1st Edition

In Vivo MR Techniques in Drug Discovery and Development

Edited By Nicolau Beckman Copyright 2006
    604 Pages 329 B/W Illustrations
    by CRC Press

    Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance (MR) Imaging is one of the principal modalities since it allows anatomical, functional, metabolic, and to a certain extent even target-related information to be gathered in vivo at high resolution, favoring the characterization of a disease state and the corresponding drug intervention. The non-invasiveness of MR strengthens the link between preclinical and clinical pharmaceutical research, contributing to improve the characterization of compound effects in early stages of the discovery process in order to increase the chances of success in later phases of drug development. Edited by a leading researcher in MR technology, with contributions from foremost experts in academia and the pharmaceutical industry, this title illustrates the use of MR techniques throughout the drug discovery and development process, from target identification and validation to clinical studies. Numerous chapters focus on individual disease areas, including neurological, cardiac, and pulmonary disorders, cancer studies, diabetes, arthritis, solid organ transplantation, and stem cell-based therapies, showing that different imaging solutions are needed for specific organs.

    The Drug Discovery and Development Process: A Brief Overview. The Drug Discovery and Development Process: Opportunities and Challenges for MR Techniques. Imaging as Biomarker for Decision-Making in Drug Development. Design of Contrast Agents for Molecular Imaging In Vivo. Rapid Phenotyping of Mice with MRI. Magnetic Resonance Imaging and Spectroscopy in Transgenic Mice Modeling Alzheimer's Disease. Imaging Alzheimer's Disease with MRI. MRI and MRS in Animal Models of Focal Cerebral Ischemia. MRI in Clinical Studies of Stroke. Pharmacologic Magnetic Resonance Imaging (phMRI). Brain fMRI in Clinical Pharmacological Studies. Imaging Inflammatory Processes of the Brain: Multiple Sclerosis as an Example. Functional and Molecular Magnetic Resonance Imaging of Preclinical Cancer Models in Drug Discovery and Development. MR for Clinical Pharmacological Studies in Cancer. Molecular Imaging in Cancer Therapies of the Future. Cardiac MR Techniques Applied to Small Rodents. Cardiac MRI Techniques for Clinical Drug Trials. Lung MRI in Small Rodents as a Tool for the Evaluation of Drugs in Models of Airways Diseases. Clinical Applications of MRI in Respiratory Diseases. MR in Preclinical Diabetes and Obesity Drug Discovery. MR in Clinical Diabetes Research and Drug Trials. Rheumatoid and Osteoarthritis: Preclinical Applications of In Vivo MR. Rheumatoid and Osteoarthritis: Clinical Applications. In Vivo Magnetic Resonance Techniques in Transplantation Research. MR Imaging and the Development of Stem Cell-Based Therapies. MRI in Pharmaceutical Safety Assessment. In Vivo MR in Pharmaceutical Research: Essential or Nice to Have? Index. ARTICLE IN PRESS


    Nicolau Beckman