1st Edition
In Vivo MR Techniques in Drug Discovery and Development
Edited By Nicolau Beckman
Copyright 2006
604 Pages
329 B/W Illustrations
by
CRC Press
604 Pages
by
CRC Press
Also available as eBook on:
Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance (MR) Imaging is one of the principal modalities since it allows anatomical, functional, metabolic, and to a certain extent even target-related information to be gathered in vivo at high resolution, favoring the... Read more
The Drug Discovery and Development Process: A Brief Overview. The Drug Discovery and Development Process: Opportunities and Challenges for MR Techniques. Imaging as Biomarker for Decision-Making in Drug Development. Design of Contrast Agents for Molecular Imaging In Vivo. Rapid Phenotyping of Mice with MRI. Magnetic Resonance Imaging and Spectroscopy in Transgenic Mice Modeling Alzheimer's Disease. Imaging Alzheimer's Disease with MRI. MRI and MRS in Animal Models of Focal Cerebral Ischemia. MRI in Clinical Studies of Stroke. Pharmacologic Magnetic Resonance Imaging (phMRI). Brain fMRI in Clinical Pharmacological Studies. Imaging Inflammatory Processes of the Brain: Multiple Sclerosis as an Example. Functional and Molecular Magnetic Resonance Imaging of Preclinical Cancer Models in Drug Discovery and Development. MR for Clinical Pharmacological Studies in Cancer. Molecular Imaging in Cancer Therapies of the Future. Cardiac MR Techniques Applied to Small Rodents. Cardiac MRI Techniques for Clinical Drug Trials. Lung MRI in Small Rodents as a Tool for the Evaluation of Drugs in Models of Airways Diseases. Clinical Applications of MRI in Respiratory Diseases. MR in Preclinical Diabetes and Obesity Drug Discovery. MR in Clinical Diabetes Research and Drug Trials. Rheumatoid and Osteoarthritis: Preclinical Applications of In Vivo MR. Rheumatoid and Osteoarthritis: Clinical Applications. In Vivo Magnetic Resonance Techniques in Transplantation Research. MR Imaging and the Development of Stem Cell-Based Therapies. MRI in Pharmaceutical Safety Assessment. In Vivo MR in Pharmaceutical Research: Essential or Nice to Have? Index. ARTICLE IN PRESS
Biography
Nicolau Beckman
