1st Edition

Inflammatory Cells and Mediators in Bronchial Asthma

    Inflammatory Cells and Mediators in Bronchial Asthma provides reviews and summaries regarding state-of-the-art articles that examine the role of various inflammatory cells and their mediators in the pathogenesis of asthma. Topics include pharmacological and biochemical regulation of the airways; involvement of key inflammatory cells and the release and effect of their mediators in airway function; and the characteristics of receptors for leukotriene B4, C4, and D4, adenosine, platelet-activating factor, sensory and inflammatory peptides, and the effect of various anti-asthmatic drugs on airway inflammation. Physicians, allergists, immunologists, and pulmonary disease research scientists will find this book to be an invaluable reference resource.

    Pharmacological and Biochemical Changes in Airway Smooth Muscle in Relation to Bronchial Hyperresponsiveness (H. Meurs, J. Zaagsma). Calcium Homeostatic Pumps in Asthma (K. Agrawal, D. Mehta). Mast Cell Mediators and Their Effect on Airway Smooth Muscle (T. Casale). Effect of Neutrophils on Airway Smooth Muscle Responsiveness (J. Sheller). Macrophages and Their Potential Role in Hyperreactive Airway Disease (J. Rankin). Role of Platelets in Altered Airway Responsiveness (A. Coyle, C. Page). Eosinophils in Airway Hyperresponsiveness (S. Makino, T. Fukuda, S. Motojima, T. Yukawa, Y. Terashi). The Autacoid Functions of Adenosine in Asthma (R. Polosa, M. Church, S. Holgate). Leukotriene Receptors in the Airways (J. Cheng, J. Eggler). Platelet-Activating Factor Receptors in Airways (D. Agrawal). Sensory and Inflammatory Peptide Receptors in the Airways (P. Barnes). The Airway and Vasoactive Intestinal Peptide Autoantibodies and Receptors (S. Paul). The Effect of Antiasthmatic Drugs on Airway Hyperresponsiveness and Inflammation (R. Pauwels).


    Devendra K. Agrawal and Robert G. Townley